Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α₁‑Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents by Chaoquan Tian (21009122)

“…Compared with <b>Tam</b>, the potency of compound <b>10</b> against α_1A-, α_1B-, and α_1D-AR decreased by 118-fold, 642-fold, and 10,000-fold, respectively. …”

Androgen Receptor Functional Analyses by High Throughput Imaging: Determination of Ligand, Cell Cycle, and Mutation-Specific Effects by Adam T. Szafran (269691)

“…This was achieved by the selective analysis of cells expressing physiological levels of AR, important because minor over-expression resulted in elevated nuclear speckling and decreased transcriptional reporter gene activity. A small screen of AR-binding ligands, including known agonists, antagonists, and endocrine disruptors, demonstrated that nuclear translocation and nuclear “speckling” were linked with transcriptional output, and specific ligands were noted to differentially affect measurements for wild type versus mutant AR, suggesting differing mechanisms of action. …”

Discovery of Tamsulosin Derivatives with Shifted Selectivity from the α₁‑Adrenergic Receptor to ANO1 as Potent Antiosteoporotic Agents by Chaoquan Tian (21009122)

“…Compared with <b>Tam</b>, the potency of compound <b>10</b> against α_1A-, α_1B-, and α_1D-AR decreased by 118-fold, 642-fold, and 10,000-fold, respectively. …”

The cyclophilin inhibitor CRV431 inhibits liver HBV DNA and HBsAg in transgenic mice by Philippe Gallay (239012)

“…We found that oral treatment with CRV431 (50 mg/kg/day) for a period of 16 days significantly reduced liver HBV DNA levels and moderately decreased serum HBsAg levels. …”

Prevalence of trachoma in Brazilian schoolchildren by Maria de Fátima Costa Lopes (12694406)

“…Chi-square and Chi-square for trends tests were used to compare categorical variables.RESULTS: There were 6,030 cases of trachoma detected, resulting in a prevalence of 5.0% (95%CI 4.5;5.4). There was no significant difference between the sexes. …”

TXNIP targets glycolysis and the pentose phosphate pathway. by Stephanie Kim (2560966)

“…In TXNIP expressing cells, metabolites that increased were displayed in red and metabolites that decreased were displayed in blue. The heat map was created using MetaboAnalyst 5.0 (<a href="https://www.metaboanalyst.ca/MetaboAnalyst/ModuleView.xhtml" target="_blank">https://www.metaboanalyst.ca/MetaboAnalyst/ModuleView.xhtml</a>) as described in Materials and methods. …”

Table 1_Impact of feed availability on growth performance and amino acid utilization of cobia (Rachycentron canadum) at elevated temperature.docx by Minh-Hoang Le (20438495)

“…</p>Methods<p>Juvenile cobia, approximately 5.0 g in body weight, were distributed across two temperature conditions: 34°C, to mimic a global warming scenario, and 30°C, the current local summer average, as controls. …”

Data_Sheet_1_Quantitative Analysis of Myocardial Work by Non-invasive Left Ventricular Pressure-Strain Loop in Patients With Type 2 Diabetes Mellitus.docx by Danqing Huang (10898289)

“…<p>Background: Type 2 diabetes mellitus (T2DM) is a common risk factor for cardiovascular diseases. …”

Data Sheet 1_Association of dietary index for gut microbiota and cardiovascular diseases in American adults: evidence from National Health and Nutrition Examination Survey 1999–201... by Hong Luo (205745)

“…Higher DI-GM levels correlated with a decreased prevalence of CVD (DI-GM: OR = 0.95, 95% CI = 0.92–0.98). …”

Characteristics prior to and at time of diagnosis in pediatric bipolar disorder by Mathilde Frahm Laursen (10775594)

“…<p>Describe symptoms before and at time of register-diagnosis in children and adolescents.</p> <p>A random sample was selected for chart-review from a Danish nationwide cohort of patients <18 years registered with an incident ICD-10 register-diagnosis of single hypomanic/manic episode or bipolar disorder between 1995 and 2014. …”

Contrasting Properties of Gene-Specific Regulatory, Coding, and Copy Number Mutations in <em>Saccharomyces cerevisiae</em>: Frequency, Effects, and Dominance by Jonathan D. Gruber (184335)

“…As a group, coding mutants had the strongest effect on reporter gene activity and always decreased it. …”

Data_Sheet_2_Meta-Analysis and Systematic Review of the Thermal Stress Response: Gallus gallus domesticus Show Low Immune Responses During Heat Stress.xlsx by Sharif Hasan Siddiqui (12012206)

“…Compared to the control, heat stress significantly decreased body mass gain (10 trials: REM = 1.35, 95% CI: 1.21, 1.50). …”

Effects of Water Depth, Seasonal Exposure, and Substrate Orientation on Microbial Bioerosion in the Ionian Sea (Eastern Mediterranean) by Claudia Färber (727434)

“…<div><p>The effects of water depth, seasonal exposure, and substrate orientation on microbioerosion were studied by means of a settlement experiment deployed in 15, 50, 100, and 250 m water depth south-west of the Peloponnese Peninsula (Greece). …”

Table_1_Changes in the Antioxidant and Mineral Status of Rabbits After Administration of Dietary Zinc and/or Thyme Extract.DOCX by Katarína Kucková (11594653)

“…<p>This study was aimed at determining the impact of organic zinc (Zn) and thyme extract (TE) administration, given alone or together for 6 weeks, on the antioxidant and mineral status (Zn, Cu, Fe, and Mn) in the plasma and tissues of growing rabbits. A total of 96 rabbits of age 35 days were randomly assigned to one of four treatment groups: a control group (C), a Zn group supplemented with dietary zinc (50 mg/kg), a TE group receiving thyme extract applied in drinking water (1 ml/L), and a Zn + TE group treated with both additives. …”

DataSheet1_Biomechanical Properties of Mouse Carotid Arteries With Diet-Induced Metabolic Syndrome and Aging.PDF by Anastasia Gkousioudi (12272495)

“…Our study showed that aging is a dominant factor affecting arterial remodeling in the adult and old mice, to a similar extent, with stiffening manifested with a significantly reduced capability of energy storage by ∼50% (p < 0.05) and decreases in material stiffness and stress (p < 0.05), regardless of diet. …”

Data_Sheet_1_Meta-Analysis and Systematic Review of the Thermal Stress Response: Gallus gallus domesticus Show Low Immune Responses During Heat Stress.docx by Sharif Hasan Siddiqui (12012206)

“…Compared to the control, heat stress significantly decreased body mass gain (10 trials: REM = 1.35, 95% CI: 1.21, 1.50). …”

Thermal-dependent product specificity over time. by Gabriel Piedrafita (155328)

“…<p>A total of 800 μM 6PG was incubated at different temperatures in 50 mM phosphate solution pH 5 containing 75 μM cysteine and 75 μM FeCl₂, and the formation of different sugar phosphate products was monitored over time. …”

Successful differentiation of AT-hMSCs into DHCs in conditioned medium. by Jung Eun Choi (563339)

“…<p>AT-hMSCs were differentiated over 3 weeks using a two-step protocol. (A) The morphology of the cells changed markedly from a fibroblast-like morphology to a polygonal shape during differentiation. …”

Effects of Individual Micronutrients on CACO-2 Tight Junctional Proteins. by Mary Carmen Valenzano (484242)

“…This same procedure was used for quercetin (400μM), butyrate (5.0mM), berberine (100μM), and indole (1.0mM) at the concentrations that provided maximal barrier enhancement and for the same time periods used in Figs <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0133926#pone.0133926.g001" target="_blank">1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0133926#pone.0133926.g002" target="_blank">2</a>. …”

Effects of active SA with RyR calcium exchange mechanisms only. by James Rosado (12456467)

“…It is worth observing that Ca²⁺ coupling is significantly decreased. In Fig 5C, 5D, and 5E, we demonstrate for spine 8 that there is a critical RyR density such that Ca²⁺ coupling occurs in the dendritic region. …”