siRNAs targeted to mouse IGF-IR in breast cancer cells. by Tiphanie Durfort (189574)

“…Significant inhibition of IGF-IR mRNA by ADT persisted for 72 h at both concentrations, whereas 50 nM of CONT1 started to decrease significantly IGF-IR mRNA at 72 h when compared to untreated cells (<i>P</i><0.001). …”

DHX29 functions an RNA co-sensor and interacts with MDA5 for enhanced RNA recognition and type I IFN signaling. by Qingyuan Zhu (121225)

“…ISRE-Luc activity was normalized to the Renilla luciferase internal control and presented as the fold decrease relative to stimulated FL-DHX29 control cells. …”

Thalidomide lowers BACE1 and reduces β-site cleavage of APP. by Ping He (33281)

“…<p>Representative images of Western blots showed β-secretase enzyme BACE1 bands in WT and littermate APP23 mice with/without thalidomide administration (<b>A</b>) and a significant decrease in BACE1 amount was found with thalidomide application (<b>A</b>, Mean ± SD, *<i>p</i><0.05, ANOVA test, n = 10 each group). …”

Transcriptional profile of spleen from rats repeatedly administered cocaine (day 7). by Moeka Nomura (10925127)

“…The data above the upper dotted line indicate a greater than 2-fold decrease caused by cocaine. …”

Comparison of normalization methods. by Mikhail G. Dozmorov (242442)

“…The procedure was repeated three times (every time with different arbitrary split of 20 samples data into 10&10 samples subgroups) and the averages and SD of the estimations are shown. A) Sensitivity and B) Precision (Y axes) for symmetrical changes in gene expression (2-fold increase in 10% and 2-fold decrease in another 10% of data). …”

Bcl-xL regulation of NF-κB RNAs: by Chi Zhang (9857)

“…F: In animal caps derived from GR-BclxL-GFP RNA injected embryos, AKBA (50 µM) inhibited the dexamethasone-induced increases in Slug, Snail, and RelA RNA levels; while treatment with AKBA alone lead to a decrease in Slug, Snail and RelA RNA levels. …”

Summary of the effects of the <i>nrdR</i> mutation on <i>P</i>. <i>aeruginosa</i> gene expression under aerobic and anaerobic conditions. by Anna Crespo (729763)

“…<b>B)</b> Distribution of genes whose expression was either increased or decreased in a Δ<i>nrdR</i> mutant strain, grouped according to fold-changes in expression levels.…”

Effect of appetite suppressants on head-weaving stereotypy in female rats. by Axl Lopez (21594203)

“…For example, the subjects represented by the red dot showed increasing levels of stereotypy over the days, whereas the subjects represented by the cyan dot transitioned from high levels of stereotypy during the first days of treatment to levels below the mean on days 6 and 7 of treatment. <b>F)</b> d-amphetamine (10 mg/kg): From the first day of treatment, subjects exhibited a level above 50% of time spent on stereotypy, which slightly increased on the second day. …”

Data_Sheet_1_Temperature limits for storage of extended boar semen from the perspective of the sperm's energy status.zip by Heiko Henning (5692907)

“…Cluster analysis revealed that the main sperm subpopulation, i.e., sperm with moderate speed and linearity, decreased from 50 to 30% (P < 0.05) in favor of slow-moving spermatozoa (5°C) or spermatozoa with a hyperactivation-like motility pattern (10°C). …”

Evolution of hnRNPA1 IDR. by Simon M. Lichtinger (11326846)

“…<b>(B)</b> Comparison of representative phase diagrams before and after genetic-algorithm runs, showing a ∼50% increase in critical temperature. Dotted lines are fits, and greyed-out points lie above the critical point, as detailed in Section <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1009328#pcbi.1009328.s001" target="_blank">S1 Text</a> (Sec. …”

Table 1_Retinal assessment in 143 patients with white matter lesions: the potential of OCTA as an evaluation tool.docx by Dong Zhang (73558)

“…</p>Conclusion<p>The severity of WMLs increases as retinal thickness and vascular density decrease. OCTA examination has a degree of role in screening for WMLs caused by cerebral microvascular disease. …”

Beta-cell proliferation is partially inhibited in RIPCre⁺Survivin^fl/fl mice after PDL. by Xiaohong Wu (147036)

“…(c)Western blots and quantification show a decrease in p21, Caspase-3, Aurora B kinase and phospho-AKT expression in islets of day 7 PDL pancreas in mutant mice (gray bars) compared to controls (black bars) (n = 5 per genotype). …”

Supplementary Material for: Gene expression and early radiation response of two distinct neuroblastoma cell lines by Ge Lin Xu (753631)

“…Understanding effects of radiation on neuroblastoma cells could improve efficacy of this final means of therapy to decrease tumor burden and stabilize the disease. …”

Differentially expressed miRNA in IC-547557 and Vivek Dhan genotypes of rice under low-N condition. by Lata Nischal (114906)

“…<p>The values indicate the fold-change decrease/increase in the miRNA expression in IC-547557 over Vivek Dhan. …”

The primary medulloblastoma chemokine signal triggering the release of RANTES is mediated by MIF. by Vita S. Salsman (220239)

“…While IL-8-KD Daoy tumors showed minimal inhibition of RANTES RNA (4.8 fold decrease), MIF-KD Daoy tumor RNA showed a 38 fold decrease in expression compared to the parental cell line Daoy. …”

Data_Sheet_1_Frequent, Short Physical Activity Breaks Reduce Prefrontal Cortex Activation but Preserve Working Memory in Middle-Aged Adults: ABBaH Study.docx by Emerald G. Heiland (9118685)

“…The effects on working memory, psychological factors, and blood glucose were also examined, and whether arterial stiffness moderated prefrontal cortex activation. Thirteen subjects (mean age 50.5 years; eight men) underwent three 3-h sitting conditions, interrupted every 30-min by a different 3-min break on separate, randomized-ordered days: seated social interactions (SOCIAL), walking (WALK), or simple resistance activities (SRA). …”

Diagrams. by Ana-Maria Buga (111779)

“…Although the numbers of BrdU-positive cells decreased dramatically by day 25, their number remained, nonetheless, at relatively high levels in the hippocampus (4.8-fold; p = 0.001)(<b>G</b>) and temporal neocortex (5.6-fold; p = 0.001) (<b>H</b>) over control levels. …”

Gene expression modulation in different development stages of studied isolates. by Vanessa Adaui (243623)

“…<p>Modulation of gene expression can be in the form of increased expression (up-regulation) or decreased expression (down-regulation); a 2-fold cutoff was used here. …”

Effects of insulin and IGF-I stimulation on the expression levels of bisecting GlcNAc <i>N</i>-glycans, in general and specifically on E-cadherin. by Julio Cesar Madureira de-Freitas-Junior (489189)

“…MDA-MB-435+E-cad cells stimulated with insulin (100 ng/mL) and IGF-I (50 ng/mL) showed a significant decrease of the overall levels of bisecting GlcNAc N-glycans. …”

Addition of ARPP-21 into the signaling network confers input-order constraint. by Anu G. Nair (461390)

“…The vertical red dotted line marks the start of calcium input. (E) The mean (solid black line) of normalized pSubstrate activation area and associated standard deviation (shaded grey region) produced by two fold increase or decrease in individual parameter values, one at a time. …”