Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

“…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC₅₀ value compared to cisplatin and low toxicity to normal cells. …”

DMB treatment improved neurological deficit and decreased infarct volume 24 h after MCAO. by Huinan Zhang (849524)

The material parameters of the 50 MPa concrete for the simulations [26]. by Xiaochao Jin (3993236)

3D snapshots of the tumor system with single-agent BHQ880 treatment at (a) time step 40, (b) time step 50 and (c) time step 120. by Minna Qiao (836556)

Effect of the Hill coefficient on estimates of <i>ε</i>_max (left column) and IC₅₀ (right column) for the logistic model with drug applied to the growth rate <... by Hope Murphy (8843516)

Partial correlation of <i>ε</i>_max (left column) and IC₅₀ (right column) estimates at 10 days and 20 days (first and second bar of each color, respectively) o... by Hope Murphy (8843516)

E₅₀ values. by Junxia Zhou (14381598)

The effect of caspase-1 inhibitor on HIV-induced changes in IL-18 and IL-18BP in IEC. by Ossama Allam (5043434)

IL-18-induced cell death is partially inhibited by inhibitors of caspase-1 and caspase-3. by Ossama Allam (5043434)

Conditional depletion of RPS0A significantly decreases translation initiation rates. by Tomáš Kouba (153719)

Mutations in <i>DHFR-TS</i> and their role in methotrexate resistance. by Sophia Bigot (16469992)

PTR1 DNA editing and absence of phenotype. by Sophia Bigot (16469992)

The receiver operating characteristic curve (ROC) for using ucfDNA molecules with a size range of 130 to 160 bp within the DHSs to distinguish control subjects with hematuria from... by Meihui Chen (1670020)

Predicted metabolite levels for each reaction intermediate shown in Figure 7 under conditions in which the NAD+:NADH ratio is 31 (Bennett et al. [26]), or decreased by either 0.1-f... by William R. Cannon (608586)

Assessment of cell proliferation within the vocal fold muscle following DFATs transplantation. by Ikuo Mikoshiba (9312007)

<i>L</i>. <i>major</i> Friedlin <i>FT1</i> single knockout. by Sophia Bigot (16469992)

Inactivation of one allele of FT5. by Sophia Bigot (16469992)

Dominant positive effect of mutated versions of <i>PTR1</i>. by Sophia Bigot (16469992)

Selected mutations in the folate transporter <i>FT1</i> and their analysis by DNA editing. by Sophia Bigot (16469992)