Controlling the G-protein signaling of Rs1 by Wei Chun Chang (43479)

“…<p>Constitutive signaling and ligand-induced signaling of Rs1 were successfully controlled by point mutations, drug choice, and domain swapping. …”

Dopaminergic cell survival in Substantia Nigra. by Vanesa Sanchez-Guajardo (254455)

“…<p>Graph illustrates the estimation of total dopaminergic neurons in SN (expressed as % of control, contralateral side values) using stereological tools in all groups and time points. A significant decrease of the number of TH+ cells was observed in the α-syn-cell death group at all time points. …”

MIF secretion is induced by IR. by Yashi Gupta (844021)

“…<p>A) Western blot of RCC4 cells treated with 4 Gy IR and lysed at various time points after exposure stained with phosphoserine 15 p53, MIF, and β-actin antibodies. …”

Hs-TnT values variation (delta) from baseline to 1-year follow-up. by Isabelle Ethier (539502)

“…Every point on the graph represents a patient.</p>…”

Theoretical analysis of electrode size. by Sadullah Canakci (4439137)

“…<b>(b)</b> Amplitude of sharp waves is plotted as a function of electrode area. <b>(c)</b> Amplitude of ripples is plotted as a function of electrode area.…”

Categorizing referred SSc patients with normal and reduced exercise capacity, using cardiopulmonary exercise testing. by Daniel Dumitrescu (329168)

“…Nine of the 11 patients classified as pulmonary vasculopathy had a decreasing P_ETCO₂. Two had either no change or increasing P_ETCO₂ from the start of exercise to the <i>AT</i>, possibly due to lung restriction. …”

Comparative Structural Studies of Iodide Complexes of Uranium(III) and Lanthanide(III) with Hexadentate Tetrapodal Neutral N-Donor Ligands by Lydia Karmazin (1580611)

“…Conversely the mean value of the U−N_pyrazine distances is shorter (0.043(3) Å for tpztn and 0.054(11) Å for tpzcn) than the mean value of the La−N_pyrazine distances. …”

Table_1_Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos.XLSX by Auke B. C. Otten (8965244)

“…Morphant embryos displayed abnormal development of the eye, brain, heart, and muscle, as well as a 50 ± 22% decrease in ATP production. Transcriptome analysis revealed a decrease in protein-encoding transcripts from the heavy strand of the mtDNA, and down-regulation of genes involved in haem production and the metabolism of metabolites, which appear to trigger increased rRNA and tRNA synthesis in the nucleoli. …”

Data_Sheet_1_Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos.PDF by Auke B. C. Otten (8965244)

“…Morphant embryos displayed abnormal development of the eye, brain, heart, and muscle, as well as a 50 ± 22% decrease in ATP production. Transcriptome analysis revealed a decrease in protein-encoding transcripts from the heavy strand of the mtDNA, and down-regulation of genes involved in haem production and the metabolism of metabolites, which appear to trigger increased rRNA and tRNA synthesis in the nucleoli. …”

Data_Sheet_3_Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos.PDF by Auke B. C. Otten (8965244)

“…Morphant embryos displayed abnormal development of the eye, brain, heart, and muscle, as well as a 50 ± 22% decrease in ATP production. Transcriptome analysis revealed a decrease in protein-encoding transcripts from the heavy strand of the mtDNA, and down-regulation of genes involved in haem production and the metabolism of metabolites, which appear to trigger increased rRNA and tRNA synthesis in the nucleoli. …”

Data_Sheet_2_Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos.pdf by Auke B. C. Otten (8965244)

“…Morphant embryos displayed abnormal development of the eye, brain, heart, and muscle, as well as a 50 ± 22% decrease in ATP production. Transcriptome analysis revealed a decrease in protein-encoding transcripts from the heavy strand of the mtDNA, and down-regulation of genes involved in haem production and the metabolism of metabolites, which appear to trigger increased rRNA and tRNA synthesis in the nucleoli. …”

Data_Sheet_4_Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos.PDF by Auke B. C. Otten (8965244)

“…Morphant embryos displayed abnormal development of the eye, brain, heart, and muscle, as well as a 50 ± 22% decrease in ATP production. Transcriptome analysis revealed a decrease in protein-encoding transcripts from the heavy strand of the mtDNA, and down-regulation of genes involved in haem production and the metabolism of metabolites, which appear to trigger increased rRNA and tRNA synthesis in the nucleoli. …”

Loss of intestinal epithelial Shh signaling deregulates intestinal crypt epithelial proliferation. by Jessica Gagné-Sansfaçon (571087)

“…Proliferation assays were performed by PCNA immunostaining (G and H, green labeling), with Evans blue serving as counterstain (red staining). Mutants displayed a decrease in cell proliferation as shown by a decrease in the number of PCNA-labeled proliferating cells (H) when compared to controls (G). …”

Antiprotease activity of HE-4 at different concentration and at different condition against various serine, cystine and aspartic proteases. by Nirmal Chhikara (124762)

“…EDTA was added to ZnCl₂ pre-treated HE-4 to check whether it can rescue the decrease in activity induced by ZnCl_2. SDS control is the % inhibition of trypsin by 5% SDS and 5% SDS point is the activity of SDS-pretreated HE-4 against trypsin. …”

Displacement of site marker ligands bound to HSA in presence of increasing PS concentrations. by Shevin R. Feroz (468333)

“…Spectra marked as ‘a’, ‘b’, ‘c’ and ‘d’ refer to 10 µM BR, 10 µM HSA, 50 µM PS and PS–HSA (5∶1) complex, respectively. …”

SOD1 mutants exert mild toxicity in the body-wall muscle cells. by Tali Gidalevitz (267374)

“…<p>(<i>A</i>) Body bends of individual animals per minute were measured. …”

Double mutant analysis of <i>tink/ibr5-6 klu-2</i> mutants compared to single mutants and wild-type. by Kim L. Johnson (204164)

“…<p>a. A significant reduction in petal area (p value ≤ 2.4e-7) is seen in <i>klu-2</i> mutants compared to wild-type and the same relative decrease in petal size occurs in double mutants of <i>tink/ibr5-6</i> with <i>klu-2</i>. b. …”

Effects of land use and microclimate changes on ant foraging in two Neotropical biomes by Icaro Wilker (17548428)

“…</p><p dir="ltr">In each site, we installed five pitfall traps in a transect and five sampling points spaced 50 meters apart to assess ant species richness and composition. …”

Diet-induced obesity. by Mónica Tramullas (2736064)

“…<p>Long-term exposure to high-fat diet increases body-weight (A), percentage of adipose body mass (B) and a relative decrease in percentage of lean body mass (C) in diet-induced obese (DIO) mice compared to lean controls fed on a low-fat diet. *** p<0.001; independent sample t-test; data represent mean ± standard error of the mean (SEM).…”

Average CTC count in 3 mL blood over time, exercise <i>vs</i>. control, at Irish and London sites. by Lauren Brady (3295164)

“…<p>Location is demonstrated separately as there is a statistically significant difference between the sites. α—significant decrease in CTC number in exercise and control groups between T0 and T3, Irish cohort (p = 0.00); β–significant decrease in CTC number in exercise and control groups between T0 and T6, Irish cohort (p = 0.00); δ—significant decrease in CTC number in exercise and control groups between T0 and T6, London cohort (p = 0.00); λ—significant decrease in CTC number in exercise and control groups between T3 and T6, London cohort (p = 0.00); σ—significant decrease in CTC number in exercise and control groups between T0 and T6, London cohort (p = 0.00). …”