Assessment of sesquiterpene lactones isolated from <i>Mikania</i> plants species for their potential efficacy against <i>Trypanosoma cruzi</i> and <i>Leishmania</i> sp. by Laura C. Laurella (469416)

“…<div><p>Four sesquiterpene lactones, mikanolide, deoxymikanolide, dihydromikanolide and scandenolide, were isolated by a bioassay-guided fractionation of <i>Mikania variifolia</i> and <i>Mikania micrantha</i> dichloromethane extracts. …”

Sensitivity analysis of model simulated [PGE2] in wild type MEF cells at 48 hours post radiation. by Chad Liu (584132)

“…The dashed line indicates the level where the fold change was equal to unity, i.e., no change in [PGE2].…”

Early Wnt/β-catenin signaling enhances cardiac differentiation. by Sharon L. Paige (247316)

The F2-isoprostane approach allows for analysis of FOXO transcription factor control of endogenous oxidative stress. by Christiaan F. Labuschagne (485155)

“…DLD-1 and DL-23 cells were incubated with 4-OHT to activate FOXO3a for 24 hours, before treatment with PQ for another 8 hours. 5-iPF2α-VI levels were analyzed and data are represented as mean fold increase ± S.E.M (*p < 0.05, *** p < 0.001).…”

C-I TF screen quantitative phenotypic analyses. by Eswar Prasad R. Iyer (177455)

“…The direction of arrow represents increase (up), decrease (down) or no change (hyphen). Size bar corresponds to 50 microns.…”

Analysis of drug delivery using the Microformulator. by Dharaminder Singh (12646624)

(Color online) Sketch of the model. by Paula Villa Martín (3220506)

“…For instance, a point close to vertex <i>T</i>¹ exploits better the limiting resource 1 (e.g. soil nutrients) than another one near vertex <i>T</i>², but is less efficient at exploiting resource 2 (e.g. light) than this latter one (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1005139#sec014" target="_blank">Methods</a>). …”

Hrq1 function and regulation in ICL repair is distinct from intrastrand crosslink repair. by Thong T. Luong (13833935)

“…The plates were photographed after 2 days of incubation at 30°C in the dark. (E) Hrq1 protein levels decreased following UV-C treatment. …”

HCMV infection elevates acetylation levels in mitochondria. by Xinlei Sheng (10654948)

“…Enriched GO biological processes are shown for proteins with increasing (red) and decreasing (blue) acetylation trends. Black indicates terms shared by both increasing and decreasing trends. …”

Adverse effect of ND251 aggregates on neurite outgrowth. by Huei-Ying Li (210957)

“…Cells expressing ND251S5A had a further decrease in the percentage of neurite-bearing cells in comparison with ND251. …”

Mismatch Repair Genes <i>Mlh1</i> and <i>Mlh3</i> Modify CAG Instability in Huntington's Disease Mice: Genome-Wide and Candidate Approaches by Ricardo Mouro Pinto (207712)

Efficacy of dexamethasone and ACTH in drug resistant pediatric epilepsy. by Nicola Marchi (4967)

“…(<b>B</b>) Mosaic plot showing the correlation between etiology of epilepsy and likelihood of a response ≥50%. Note that etiology did not always predict response. …”

Different simulation protocols of increased firing and depressed activity. by Isabelle Ayumi Spühler (444465)

“…After 4 sec, 50% of release sites increase or decrease their release for a short time window to simulate phasic firing of the dopaminergic neurons. …”

Sensitivity of biomass and cumulative harvest to magnitude of climate impacts under alternative management strategies. by Jameal F. Samhouri (10136090)

“…<p>Outcomes of implementing fixed versus annual climate adaptive harvest management strategies on mean population biomass and cumulative harvest over 50-year simulations in a population subject to a gradual decrease or increase in carrying capacity <b>(a, d)</b>, productivity <b>(b, e)</b>, and both carrying capacity and productivity <b>(c, f)</b>. …”

Percent differences between the fixed and climate adaptive harvest management strategies in mean biomass and cumulative harvest at different time intervals in the simulations. by Jameal F. Samhouri (10136090)

“…<p>Percent differences in mean biomass and cumulative harvest between the fixed and climate adaptive harvest management strategies for 16-year time intervals throughout the 50-year simulations in populations subject to a gradual decrease in (a) carrying capacity, (c) productivity, (e) both carrying capacity and productivity, or a gradual increase in (b) carrying capacity, (d) productivity, (f) both carrying capacity and productivity. …”

HRas^V12 expression in epithelial cells induces cell shape and genetic changes associated with EMT <i>in vivo</i>. by Christina M. Freisinger (246174)

“…(B–C) Fluorescent Z stack projections of HRas^WT and HRas^V12 expressing epithelial cells (magenta) in the trunk region of 3.5 dpf larvae (illustrated in A). (D–E) Lateral fluorescent images, from live imaging, of 3.5 dpf embryos co-expressing GFP-H2B to label the nuclei and either HRas^WT (D) or HRas^V12 (E) at 0, 2 hr and 4 hr time points. …”

Image_6_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”

Image_4_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”

Neuronal complexity was greatly reduced by neuronal GALC depletion. by Conlan Kreher (13001753)

“…<p>(<b>A, B</b>) Double transgenic mice of 1-year-old <i>Syn1Cre; Galc flox/−;</i> Thy1.1-YFP shows that a decrease in the density of YFP neurons/axons in the brainstem and cerebellum, compared to control (<i>Galc +/−;</i> Thy1.1-YFP). …”

Image_1_The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma.TIF by Yang Kong (3376658)

“…GG inhibited viability and proliferation of GBM cells (U251, U87MG, and A172) in a dose-dependent manner (IC₅₀ = 221.8, 262.5, 273.9 μM, respectively; P < 0.001; EdU, ~40% decrease at 150 μM, P < 0.001), and the number of colonies formed was significantly reduced (at 50 μM, P < 0.001). …”