Modeled robustness and tunability from negative-feedback-only versus positive-plus-negative feedback. by Tony Y.-C. Tsai (521831)

Relationship between calcitriol and GDNF signaling. by Rowan P. Orme (405955)

“…(A, B) 10 nM calcitriol added to media caused almost a 1.8-fold increase in GDNF expression, observed by Western blotting. …”

Image1_Ameliorative Effects of Osthole on Experimental Renal Fibrosis in vivo and in vitro by Inhibiting IL-11/ERK1/2 Signaling.pdf by Fan Wu (43375)

Depletion of viral IE2 in late infection does not affect viral long promoter transcription. by Qiaolin Hu (8677473)

“…Viral TSSs that exhibited a ≥ 2-fold increase or ≥50% decrease in strength due to IE2 depletion (demarcated by hatched lines) were classified as IE2-responsive and are indicated by green dots. …”

Data_Sheet_1_Excess Mortality in Italy During the COVID-19 Pandemic: Assessing the Differences Between the First and the Second Wave, Year 2020.PDF by Maria Dorrucci (252694)

“…The models were also applied to estimate all-cause excess deaths “not directly attributable to COVD-19”, i.e., without a previous COVID-19 diagnosis. During the first wave (25th February−31st May), we estimated 52,437 excess deaths (95% CI: 49,213–55,863) and 50,979 (95% CI: 50,333–51,425) during the second phase (10th October−31st December), corresponding to percentage 34.8% (95% CI: 33.8%–35.8%) in the second wave and 31.0% (95%CI: 27.2%–35.4%) in the first. …”

Somatic <i>HTT</i> CAG instability differs between B6.<i>Hdh^Q111</i>^/+ and 129.<i>Hdh^Q111</i>^/+ mice. by Ricardo Mouro Pinto (207712)

Data_Sheet_2_Excess Mortality in Italy During the COVID-19 Pandemic: Assessing the Differences Between the First and the Second Wave, Year 2020.PDF by Maria Dorrucci (252694)

“…The models were also applied to estimate all-cause excess deaths “not directly attributable to COVD-19”, i.e., without a previous COVID-19 diagnosis. During the first wave (25th February−31st May), we estimated 52,437 excess deaths (95% CI: 49,213–55,863) and 50,979 (95% CI: 50,333–51,425) during the second phase (10th October−31st December), corresponding to percentage 34.8% (95% CI: 33.8%–35.8%) in the second wave and 31.0% (95%CI: 27.2%–35.4%) in the first. …”

Temporal analysis of behavioral transitions across five time intervals in the visual cliff setup. by Hironobu Shuto (22127141)

“…Circular paths show consistent cliff effects during the 0–3 min interval, with clear transitions in state fractions between points “a” and “b”. However, the cliff effect diminishes during the 6–9 min interval and reappears in the 12–15 min interval, though its interpretation is complicated by changing state definitions (e.g., progressively smaller step lengths). …”

Summary of the effects of deletion of Y2 receptors on non-NPY-ergic or NPY-ergic neurons in the brain. by Yan-Chuan Shi (153820)

“…However, Y2 receptors on NPY-ergic neurons in the amygdala induce anxiogenic effects <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011361#pone.0011361-Tasan1" target="_blank">[50]</a>, likely due to decreased endogenous NPY-ergic action <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011361#pone.0011361-Heilig1" target="_blank">[56]</a>. …”

Validation of complete model with trafficking and phosphorylation parameters. by Lindsay Wendel Clegg (754229)

“…TIME cells, [V] = 50 ng/mL, measurements taken at t = 5 min. In the model, the experimentally observed decrease in VEPTP expression to 20% of control values with VEPTP siRNA was simulated by decreasing the dephosphorylation rate for Y951 and Y1175 by a factor of 5 on the cell surface. …”

Nrf2-target gene expression is up-regulated by AD2 and NST domains of Nrf1 within chimaeras N607:C270^Nrf2 and Nrf1β^N607:C270^Nrf2, but is also down-... by Yiguo Zhang (512679)

“…These expression constructs for Nrf2 and its chimaeric proteins, together with <i>P_SV40Nqo1</i>-ARE-Luc and β-gal reporters, were co-transfected into either COS-1 cells (<i>right panel</i> of <b><i>D</i></b>) or RL-34 cells (<b>E</b>), before luciferase activity was assayed and the data are presented as fold changes (mean ± S.D). …”

DataSheet1_Steroid implants for the induction of vitellogenesis in feminized European silver eels (Anguilla anguilla L.).docx by Arjan P. Palstra (8178282)

“…Only eels of the 17 MT-group showed increased expression of cyp19 and of fshr, while fshr expression increased 44-fold in the 17 MT + E2 group, highlighting that co-implantation is most effective in raising fshr mRNA levels. …”

Responses of earthworms to worm grunting vibrations. by Kenneth C. Catania (247359)

“…Their speed progressively decreased over time. F. The paths of 2 worms showing their point of emergence (up arrow) their position every 30 seconds (dots) and the relative location at which they burrowed back into the ground (down arrow), with burrowing time indicated.…”

Direct effects of duration. by Martin Wiener (249995)

“…Error bars indicate s.e. of the mean. (<b>c</b>) Individual participant performance for the bisection point (x-axis) and coefficient of variation (y-axis) values derived from psychometric data, as well as marginal histograms for each; there were no differences between BP values for auditory or visual participants, but significantly lower CV values for the auditory task.…”

Samples of psychometric functions under different conditions in Experiment 1. by Wei Liu (20030)

“…The vertical dashed lines indicate the PSEs (i.e., the point of subjective equality) of the match, which were clearly higher than the probe number (indicated by the arrow) when adapted under the no-mask (open circles), monoptic-mask (open rectangles), and dichoptic-mask (open triangles) conditions. …”

Validation of both the dose and infused patterns of CORT within the circulation of the rat. by Benjamin P. Flynn (11256176)

“…CORT levels gradually increased from basal (Zt 0–6) to maximal levels at Zt 12:40. Levels decreased from this point returning to baseline by Zt 22. …”

Influence of <i>k</i>₁ on the homeostatic behavior of the m7 ping-pong controller when <i>E</i>₁ binds first to free enzyme <i>Ez</i>. by Qaiser Waheed (5095328)

“…(c) A decrease of <i>k</i>₆ from 5.0 to 1.0 while <i>k</i>₁ is kept at 100.0 gives a general improvement of the homeostatic performance of the ping-pong controller, except for the higher end <i>k</i>₅ range between 900–1000, where <i>A</i>_<i>ss</i> becomes constant (indicated by the red circle). …”

Inter-county mobility patterns reflect social distancing and travel restrictions. by Hengfang Deng (7003667)

“…While the data only lost a small number of devices, the two measures both plummeted more than 50% within two weeks before recovering.…”

Supplementary Material for: Polypharmacy and the Progression of Chronic Kidney Disease: Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease by Min H.K. (10922121)

“…Polypharmacy was defined as taking 6 or more medications at the time of enrollment; renal events were defined as a ≥50% decrease in kidney function from baseline values, doubling of the serum creatinine levels, or initiation of renal replacement treatment. …”

hERG Potassium Channel Blockage by Scorpion Toxin BmKKx2 Enhances Erythroid Differentiation of Human Leukemia Cells K562 by Jian Ma (170138)

“…</p> <p>Principal Findings</p><p>The hERG potassium channel blockage by a new 36-residue scorpion toxin BmKKx2, a potent hERG channel blocker with IC₅₀ of 6.7±1.7 nM, enhanced the erythroid differentiation of K562 cells. …”