Image_3_Converging and Differential Brain Phospholipid Dysregulation in the Pathogenesis of Repetitive Mild Traumatic Brain Injury and Alzheimer’s Disease.JPEG by Joseph O. Ojo (5539157)

“…Cortex and hippocampal tissue were collected at 24 h, 3, 6, 9, and 12 months post-rmTBI, and at ages representing ‘pre’, ‘peri’ and ‘post’ onset of amyloid pathology (i.e., 3, 9, 15 months-old). Total levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), LysoPE, and phosphatidylinositol (PI), including their monounsaturated, polyunsaturated and saturated fatty acid (FA) containing species were significantly increased at acute and/or chronic time points post-injury in both brain regions. …”

Image_12_Converging and Differential Brain Phospholipid Dysregulation in the Pathogenesis of Repetitive Mild Traumatic Brain Injury and Alzheimer’s Disease.JPEG by Joseph O. Ojo (5539157)

“…Cortex and hippocampal tissue were collected at 24 h, 3, 6, 9, and 12 months post-rmTBI, and at ages representing ‘pre’, ‘peri’ and ‘post’ onset of amyloid pathology (i.e., 3, 9, 15 months-old). Total levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), LysoPE, and phosphatidylinositol (PI), including their monounsaturated, polyunsaturated and saturated fatty acid (FA) containing species were significantly increased at acute and/or chronic time points post-injury in both brain regions. …”

Image_6_Converging and Differential Brain Phospholipid Dysregulation in the Pathogenesis of Repetitive Mild Traumatic Brain Injury and Alzheimer’s Disease.JPEG by Joseph O. Ojo (5539157)

“…Cortex and hippocampal tissue were collected at 24 h, 3, 6, 9, and 12 months post-rmTBI, and at ages representing ‘pre’, ‘peri’ and ‘post’ onset of amyloid pathology (i.e., 3, 9, 15 months-old). Total levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), LysoPE, and phosphatidylinositol (PI), including their monounsaturated, polyunsaturated and saturated fatty acid (FA) containing species were significantly increased at acute and/or chronic time points post-injury in both brain regions. …”

Image_7_Converging and Differential Brain Phospholipid Dysregulation in the Pathogenesis of Repetitive Mild Traumatic Brain Injury and Alzheimer’s Disease.JPEG by Joseph O. Ojo (5539157)

“…Cortex and hippocampal tissue were collected at 24 h, 3, 6, 9, and 12 months post-rmTBI, and at ages representing ‘pre’, ‘peri’ and ‘post’ onset of amyloid pathology (i.e., 3, 9, 15 months-old). Total levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), LysoPE, and phosphatidylinositol (PI), including their monounsaturated, polyunsaturated and saturated fatty acid (FA) containing species were significantly increased at acute and/or chronic time points post-injury in both brain regions. …”

Image_11_Converging and Differential Brain Phospholipid Dysregulation in the Pathogenesis of Repetitive Mild Traumatic Brain Injury and Alzheimer’s Disease.JPEG by Joseph O. Ojo (5539157)

“…Cortex and hippocampal tissue were collected at 24 h, 3, 6, 9, and 12 months post-rmTBI, and at ages representing ‘pre’, ‘peri’ and ‘post’ onset of amyloid pathology (i.e., 3, 9, 15 months-old). Total levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), LysoPE, and phosphatidylinositol (PI), including their monounsaturated, polyunsaturated and saturated fatty acid (FA) containing species were significantly increased at acute and/or chronic time points post-injury in both brain regions. …”

Image_1_Converging and Differential Brain Phospholipid Dysregulation in the Pathogenesis of Repetitive Mild Traumatic Brain Injury and Alzheimer’s Disease.JPEG by Joseph O. Ojo (5539157)

“…Cortex and hippocampal tissue were collected at 24 h, 3, 6, 9, and 12 months post-rmTBI, and at ages representing ‘pre’, ‘peri’ and ‘post’ onset of amyloid pathology (i.e., 3, 9, 15 months-old). Total levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), LysoPE, and phosphatidylinositol (PI), including their monounsaturated, polyunsaturated and saturated fatty acid (FA) containing species were significantly increased at acute and/or chronic time points post-injury in both brain regions. …”

MYCN governs a malignant NB cell identity by directly activating canonical MYC target genes and suppressing neuronal differentiation genes. by Zhihui Liu (95891)

“…(<b>C</b>) and (<b>D</b>) <i>MYCN</i> knockdown in IMR32 cells increases neurite length as assessed by the IncuCyte neurite analysis assays and phase-contrast images. (<b>E</b>) <i>k</i>-Means clustering of MYCN and histone marks ChIP-seq around MYCN binding sites of NB cell line IMR32 (±3 kb) shows that MYCN binds to proximal regulatory elements containing active promoters marked by H3K27ac and H3K4me3 signals, and binds distal regulatory elements containing enhancers marked by H3K4me1 and H3K27ac signals. …”

Identification of significant up- or down-regulated genes on each day during regression and regeneration of the oviduct. by Wooyoung Jeong (124130)

GBE modulated mitochondrial flux control ratios and rose ATP synthesis. by Virginie Rhein (243241)

“…(<b>A–C</b>) Values represent the means ± S.E., GBE treatment effect, paired student's t-test, number of pairs n = 5: #, p<0.05, ##, p<0.01 GBE treated versus corresponding untreated cells; and effect of Aβ, unpaired student's t-test, n = 5, *, p<0.05; ***, p<0.001 APP versus control cells.…”

Expression of RIO kinases is associated with EGFR and Akt activity in GBM cells. by Renee D. Read (268044)

“…(G) Neurosphere cultures treated for 24 hours with DMSO or indicated inhibitors. P110 inhibitors: 50 µM LY294002, 1 µM BEZ-235, 2 µM GDC-0941 <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003253#pgen.1003253-Raynaud1" target="_blank">[71]</a>, 2 µM PI-103 <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003253#pgen.1003253-Raynaud1" target="_blank">[71]</a>. …”

Plasma MicroRNAs as Potential Noninvasive Biomarkers for In-Stent Restenosis by Meijiao He (666387)

“…</p><p>Methods</p><p>This retrospective, observational single-centre study was conducted at the cardiovascular department of a tertiary hospital centre in the north of China. …”

DataSheet_1_Transcriptome analysis reveals that auxin promotes strigolactone-induced adventitious root growth in the hypocotyl of melon seedlings.pdf by Jingrui Li (1546318)

“…Compared to that in the control, the ABA content decreased by 10.30%–11.83% in the GR24 treatment group and decreased by 18.78%-24.00% in the GR24+IAA treatment group at 6–10 days.…”

Enhanced drug resistance suppression by serum-stable micelles from multi-arm amphiphilic block copolymers and tocopheryl polyethylene glycol 1000 succinate by Lei He (143930)

“…<p><b>Aim:</b> To develop a robust drug-delivery system using multi-arm amphiphilic block copolymers for enhanced efficacy in cancer therapy.…”

Data_Sheet_1_MicroRNA29B induces fetal hemoglobin via inhibition of the HBG repressor protein MYB in vitro and in humanized sickle cell mice.docx by Qingqing Gu (338902)

“…</p>Materials and methods<p>Human KU812 were cultured and normal CD34 cells (n = 3) were differentiated using a two-phase erythropoiesis culturing system and transfected with MIR29B (50 and 100 nM) mimic or Scrambled (Scr) control in vitro. …”

Early initiation of breastfeeding and severe illness in the early newborn period: An observational study in rural Bangladesh by Shahreen Raihana (828393)

“…id=362279" target="_blank">ACTRN12612000588897</a>.</p></div>…”

Analysis of multiple cell lines by Fluidigm. by Evan N. Cohen (507021)

“…Media control appears as a solid black line at 1 in the center of each plot, points falling outside the circle represent increased relative expression and lines inside are decreased. …”

Tmub1/HOPS facilitates the surface expression of GluR2, but not of GluR1. by Hyunjeong Yang (271171)

“…The values shown indicate the means±SEM. Scale bar, 10 µm.</p>…”

NR4A1 plays a role in RCC proliferation. by Erik Hedrick (748501)

“…(F) Athymic nude mice bearing ACHN cells as xenografts were treated with 30 mg/kg/d DIM-C-pPhOH and tumor volumes were determined. Results (C—E) are means ± SE for at least 3 separate determinations and significantly (p < 0.05) decreased growth/volume is indicated (*). …”

Evidence for rapid downward fecundity selection in an ectoparasite (Philornis downsi) with earlier host mortality in Darwin’s finches by Sonia Kleindorfer (95761)

“…In other years and locations, traps were placed ad hoc every 50 m within 100 m x 200 m plots spanning a 2 km transect within study sites. …”

Prevention of glutathione depletion in the mitochondria (A) and in the cytoplasm (B) of hepatocytes following reperfusion injury. by Romain Coriat (171822)

“…Immunofluorescence microscopy of HepG2 cells stained with oxidation of dihydroethidium (DHE) and treated for 18 h or not with mangafodipir. (D–E) A decreased intensity of cytosol with mangafodipir in mangafodipir treated cells was observed.…”