WT mice (gray) display a greater increase in insulin resistance than <i>Dp(11)17/+</i> mice (red) after HF diet from 19 to 22 weeks as well as an increased weight gain after a long... by Melanie Lacaria (162331)

“…<p>(A) During IP-GTT, WT mice display more dramatically decreased glucose clearance rate (*p = 0.00011) after HF diet than <i>Dp(11)17/+</i> mice (*p = 0.03). …”

Table_2_Integrated Analysis of mRNA and miRNA Expression Profiles in the Ovary of Oryctolagus cuniculus in Response to Gonadotrophic Stimulation.DOCX by Shenqiang Hu (3687574)

“…Ovaries of 6 does at different time points during gonadotrophic stimulation were collected for histomorphological examination and genome-wide analysis of miRNA and mRNA transcriptomes, and the plasma were separated for detecting melatonin (MT), prostaglandin E₂ (PGE₂), estradiol (E₂), and progesterone (P₄) levels. …”

Image_3_Integrated Analysis of mRNA and miRNA Expression Profiles in the Ovary of Oryctolagus cuniculus in Response to Gonadotrophic Stimulation.TIF by Shenqiang Hu (3687574)

“…Ovaries of 6 does at different time points during gonadotrophic stimulation were collected for histomorphological examination and genome-wide analysis of miRNA and mRNA transcriptomes, and the plasma were separated for detecting melatonin (MT), prostaglandin E₂ (PGE₂), estradiol (E₂), and progesterone (P₄) levels. …”

Image_2_Integrated Analysis of mRNA and miRNA Expression Profiles in the Ovary of Oryctolagus cuniculus in Response to Gonadotrophic Stimulation.TIF by Shenqiang Hu (3687574)

“…Ovaries of 6 does at different time points during gonadotrophic stimulation were collected for histomorphological examination and genome-wide analysis of miRNA and mRNA transcriptomes, and the plasma were separated for detecting melatonin (MT), prostaglandin E₂ (PGE₂), estradiol (E₂), and progesterone (P₄) levels. …”

Data_Sheet_1_Stroke patients have lower blood levels of nutrients that are relevant for recovery: a systematic review and meta-analysis.docx by Laus M. Broersen (17626701)

“…No significant decreases were observed for vitamin B6 (k = 6; p = 0.52) and arginine (k = 4; p = 0.93). …”

The role of Trp1322 in the regulation of calcium homeostasis in fission yeast. by Yan Ma (88810)

“…(B) When Trp1322 was overexpressed, the high basal CDRE-reporter activity was significantly decreased by the addition of NaCl. Note the marked activation of the reporter activity by the same stimuli in non-induced cells (Promoter OFF, left pannel). …”

Block of S-phase progression at the S0 to S1 transition arrests the erythroid differentiation program. by Ramona Pop (34809)

“…(G) S-phase arrest by overexpression of a non-degradable mutant of p57^KIP2 (p57T329A). …”

Ethynyl deoxyuridine dose titration for labeling lateral ventricular wall cells in adult mouse brain by Hyung-song Nam (8914220)

“…Reducing the formaldehyde concentration and/or the fix time increased the specific signal and reduced the non-specific autofluorescence background. Presumably this means the 4% formaldehyde "over-fixed" the specimen.…”

CenRICH is suitable for long read sequencing and DNA methylation analysis. by Riccardo Gamba (3458696)

“…Right panel shows a portion of cen18 where methylation calls derive from a coverage of more than 10 reads in both samples. <b>E.</b> Distribution of CpG sites based on the minimum coverage. …”

Enrichment of Treg cells at the disease site of visceral leishmaniasis (VL) patients: by Ambak K. Rai (185132)

“…CD4⁺CD25⁺ cells were significantly enriched in BM-MNCs as compared to PBMCs of VL patients (<i>p = 0.016, unpaired t test</i>). A statistically non-significant increase is also observed in PBMCs of VL patients in comparison with that of HCs (<i>p = 0.060, Unpaired t test</i>). …”

DNA/MVA Vaccination of HIV-1 Infected Participants with Viral Suppression on Antiretroviral Therapy, followed by Treatment Interruption: Elicitation of Immune Responses without Con... by Melanie Thompson (207727)

“…<div><p>GV-TH-01, a Phase 1 open-label trial of a DNA prime—Modified Vaccinia Ankara (MVA) boost vaccine (GOVX-B11), was undertaken in HIV infected participants on antiretroviral treatment (ART) to evaluate safety and vaccine-elicited T cell responses, and explore the ability of elicited CD8+ T cells to control viral rebound during analytical treatment interruption (TI). …”

datasheet1_The Expiry of Humira® Market Exclusivity and the Entry of Adalimumab Biosimilars in Europe: An Overview of Pricing and National Policy Measures.pdf by Evelien Moorkens (4723848)

“…When reported, discounts/rebates on originator adalimumab after loss of exclusivity ranged from 0% to approximately 26% (Romania), 60% (Poland), 80% (Denmark, Italy, Norway), and 80–90% (Netherlands), leading to actual prices per pen or syringe between €412 (Finland) and €50 – €99 (Netherlands). To leverage competition following entry of biosimilar adalimumab, only a few countries adopted measures specifically for adalimumab in addition to general policies regarding biosimilars. …”

Toll-Like Receptor-2 Mediates Diet and/or Pathogen Associated Atherosclerosis: Proteomic Findings by Monika Madan (95727)

“…</p><h3>Methods and Results</h3><p>To explore the role of TLR2 in inflammation- and infection-associated atherosclerosis, 10 week-old ApoE^+/−-TLR2^+/+, ApoE^+/−-TLR2^+/− and ApoE^+/−-TLR2^−/− mice were fed either a high fat diet or a regular chow diet. All mice were inoculated intravenously, once per week for 24 consecutive weeks, with 50 µl live <em>Porphyromonas gingivalis</em> (<em>P.g</em>) (10⁷ CFU) or vehicle (normal saline). …”

Thymoquinone loaded nanoemulgel in streptozotocin induced diabetic wound by Urati Anuradha (20306190)

“…<p><b>Aim:</b> To treat diabetic wound healing with a novel Thymoquinone (TQ) loaded nanoformulation by using combination of essentials oils.…”

Acute effect of timolol on intracellular global Ca²⁺ changes, and the basal levels of intracellular both free Zn²⁺ and Ca²⁺ in ventricular hypergly... by Erkan Tuncay (438815)

“…(C) To record basal levels of both intracellular free Zn²⁺ and Ca²⁺ in resting cells in parallel, we used a ratiometric Fura-2 (4-µM Fura-2 AM) loaded cells and 50-µM N,N,N′,N′-tetrakis (2-pyridylmethyl) ethylenediamine (TPEN) (for more information about methods, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071014#pone.0071014-Tuncay1" target="_blank">[28]</a>). …”

Image_8_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

Image_2_Combined Effect of CYP2C19 Genetic Polymorphisms and C-Reactive Protein on Voriconazole Exposure and Dosing in Immunocompromised Children.JPEG by Juan Chen (61123)

“…Covariates associated with voriconazole plasma concentrations and dose requirements were adjusted by using generalized linear mixed-effect models.</p>Results<p>A total of 682 voriconazole steady-state trough concentrations from 91 Chinese pediatric patients were included. …”

Image_5_Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphom... by Fen Yang (287005)

“…</p><p>Results: In this phase Ia study, a total of eight subjects participated. VCR elimination from the circulation after injection of VSLI was characterized by a significantly increased maximum concentration (C_max, 86.6 ng/mL) and plasma area under the plasma concentration-time curve from zero to infinity (AUC_0-Inf, 222.1 ng/mL h), markedly decreased distribution volume (V_z, 224.1 L) and plasma clearance (CL, 8.9 L/h) compared to lower C_max (26.6 ng/mL) and AUC_0-Inf (95.1 ng/mL h), larger V_z (688.8 L) and CL (22.1 L/h) for VSI. …”

4-Octyl itaconate attenuates renal tubular injury in db/db mice by activating Nrf2 and promoting PGC-1α-mediated mitochondrial biogenesis by Muqing Shao (15238576)

“…<i>Irg1</i> knockout mice were generated. db/db mice were treated with 4-octyl itaconate (4-OI, 50 mg/kg), a derivative of itaconate, for 4 weeks. …”

Simulated dependence of [Ca²⁺] on electrical coupling following modulation of other K_ATP parameters. by Aleena M. Notary (625801)

“…<b>B).</b> As in A, for <i>g</i>_<i>coup</i> = 0pS. <b>C).…”