Cerebral Hemodynamics in Patients with Hemolytic Uremic Syndrome Assessed by Susceptibility Weighted Imaging and Four-Dimensional Non-Contrast MR Angiography by Ulrike Löbel (3325251)

“…TTP ranged from 3.7 to 10.2 frames (mean, 7.9 ± 1.4). Hemoglobin at the time of MRI (n = 35) was decreased in all patients (range, 5.0 to 12.6 g/dL; mean, 8.2 ± 1.4); hematocrit (n = 33) was abnormally low in all but a single patient (range, 14.3 to 37.2%; mean, 23.7 ± 4.2). …”

Discovery of 2‑Aryl-4-aminoquinazolin-Based LSD1 Inhibitors to Activate Immune Response in Gastric Cancer by Bo Wang (86769)

“…Novel LSD1 inhibitors with different mechanisms are therefore needed. Herein, we reported a series of novel quinazoline-based LSD1 inhibitors. …”

Data_Sheet_1_Altered Behaviors and Impaired Synaptic Function in a Novel Rat Model With a Complete Shank3 Deletion.PDF by Tian-Jia Song (6506489)

Dataset. by Elizabeth Chappell (4807257)

“…The estimated proportion of women who were retested among those initially negative in pregnancy fell markedly in April 2020 (39% reduction (32–45%), p<0.001) and the subsequent increase was much slower, only reaching 39% by September 2021 compared to average 53% pre-pandemic. The mean estimated proportion of pregnant women with HIV on ART was unchanged at programme-level (98% vs 98%, p = 0.26), but decreased at population-level (86% vs 80%, p = 0.049). …”

Definition of indicators. by Elizabeth Chappell (4807257)

“…The estimated proportion of women who were retested among those initially negative in pregnancy fell markedly in April 2020 (39% reduction (32–45%), p<0.001) and the subsequent increase was much slower, only reaching 39% by September 2021 compared to average 53% pre-pandemic. The mean estimated proportion of pregnant women with HIV on ART was unchanged at programme-level (98% vs 98%, p = 0.26), but decreased at population-level (86% vs 80%, p = 0.049). …”

Cascades of care over time. by Elizabeth Chappell (4807257)

“…The estimated proportion of women who were retested among those initially negative in pregnancy fell markedly in April 2020 (39% reduction (32–45%), p<0.001) and the subsequent increase was much slower, only reaching 39% by September 2021 compared to average 53% pre-pandemic. The mean estimated proportion of pregnant women with HIV on ART was unchanged at programme-level (98% vs 98%, p = 0.26), but decreased at population-level (86% vs 80%, p = 0.049). …”

Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors by Russell Fritzemeier (5538416)

“…While mouse genetic studies suggest that Spns2 functions to maintain lymph S1P, Spns2 inhibitors are necessary to understand its biology and to learn whether Spns2 is a viable drug target. Herein, we report a structure–activity relationship study that identified the first Spns2 inhibitor <b>16d</b> (SLF1081851). …”

Overexpression of UHRF1 promotes bladder cancer cell invasion. by Yu Zhang (12946)

Systemic effects in naïve mice injected with immunomodulatory lectin ArtinM by Patrícia Kellen Martins Oliveira Brito (4543702)

“…IL-12, IFN-γ, TNF-α, and IL-10 measurements in the liver, kidney, spleen, heart, and lung homogenates revealed decreased IL-10 level in the heart and lung of mice injected with 5.0 μg ArtinM. …”

Inhibition of glycolysis inhibits replication of SVA. by Huizi Li (6241586)

YR subtype selectivity of Y₄R PAMs. by Gregory Sliwoski (2832971)

“…Receptors were stimulated with their native ligands (Y₁R, Y₂R, Y₅R: NPY; Y₄R: PP). For Y-axis values, positive modulation represents an increase in the apparent potency (pEC₅₀) of the native agonist and negative modulation represents a decrease in the apparent potency of the native agonist. …”

Sequential viral exposure creates an inflammatory host environment. by Yuhao Li (1559569)

Efficacy of MVATG18598 vaccination schedule in the post-exposure BALB/c mouse model. by Stéphane Leung-Theung-Long (830219)

Cilia disassembly proceeds at a faster rate in CCDC66-depleted cells, which is regulated by the AurkA-HDAC6 axis and rescued by microtubule stabilization. by Jovana Deretic (13113617)

“…Cilia length was quantified in 3D according to ARL13b signal (co-localizing with acetylated-tubulin). The mean cilia length in CCDC66-depleted cells decreased to 0.74-fold compared to the mean control length at 0 h. …”

Supplementary Material for: Upregulation of miRNA-26a enhances the apoptosis of cerebral neurons by targeting EphA2 and inhibiting the MAPK pathway by Chi B. (13546486)

Important model parameters. by Yechu Hua (12652945)

Effect of MMP9 on periostin expression. by Nabila Djaziri (17537499)

Effects of a person-centred telephone-support in patients with chronic obstructive pulmonary disease and/or chronic heart failure – A randomized controlled trial by Andreas Fors (5706587)

“…</p><p>Method</p><p>221 patients ≥ 50 years with COPD and/or CHF were randomized to usual care vs. usual care plus a person-centred telephone-support intervention and followed for six months. …”

MVATG18598 immunization triggers Mtb antigen-specific cells producing IFNγ and induces cells with antigen-specific cytolytic activity. by Stéphane Leung-Theung-Long (830219)

Autophagosome detection in left ventricle (LV) sections, and LC3 expression in mdx mice cardiomyocytes. by Takuya Hirata (1604398)