Bioassay and NMR-HSQC-Guided Isolation and Identification of Phthalide Dimers with Anti-Inflammatory Activity from the Rhizomes of Angelica sinensis by Hongyan Wen (9226895)

“…Among them, compound <b>9</b> showed a remarkable inhibitory activity with IC₅₀ values of 425 nM and could significantly decrease IL-1β and IL-6 transcription levels. …”

Bioassay and NMR-HSQC-Guided Isolation and Identification of Phthalide Dimers with Anti-Inflammatory Activity from the Rhizomes of Angelica sinensis by Hongyan Wen (9226895)

“…Among them, compound <b>9</b> showed a remarkable inhibitory activity with IC₅₀ values of 425 nM and could significantly decrease IL-1β and IL-6 transcription levels. …”

(A) Growth of <i>M</i>. <i>smegmatis ΔFtsEX</i> cells with rifampicin [350 μg/ml] with the time interval between consecutive microdialysis steps doubled to 2 hours—across the vario... by Brilliant B. Luthuli (785964)

Platinum-Based Modification of Styrylbenzylsulfones as Multifunctional Antitumor Agents: Targeting the RAS/RAF Pathway, Enhancing Antitumor Activity, and Overcoming Multidrug Resis... by Zhikun Liu (389939)

“…Among them, compound <b>29</b> showed the most potent antitumor activity in vitro with IC₅₀ values at the nanomolar level against the tested tumor cell lines and 1000-fold higher than cisplatin against the multidrug resistant cells (A549/CDDP, A549/DOX, and SKOV-3/CDDP cells), while it showed only moderate cytotoxicity against normal cells (HEUVC cells). …”

Validation of selected genes associated with p53 connection pathway was carried out using quantitative real-time polymerase chain reaction (qRT-PCR) and western immunoblotting. by Mei Yi Sim (4067998)

Tuning Magnetic and Structural Transitions through Valence Electron Concentration in the Giant Magnetocaloric Gd_5–<i>x</i>Eu_<i>x</i>Ge₄ Phases by Jinlei Yao (1712740)

“…A decrease in the valence electron concentration achieved through the substitution of Eu²⁺ for Gd³⁺ leads to the formation of the interslab Ge–Ge dimers, phase transitions to the Gd₅Si₂Ge₂- and Gd₅Si₄-type structures, and a ferromagnetic ordering in the Gd_5–<i>x</i>Eu_<i>x</i>Ge₄ system. …”

Shell colour luminance variation of three phenotypic groups according to background and sutural band colour categories for yellow shells of <i>Polymita picta</i>. by Mario Juan Gordillo-Pérez (20565248)

Craving scales. by Francesco Lolli (2530471)

Two-dimensional quadrant analysis of cherry shrimp (<i>N</i>. <i>davidi</i> var. red) bodycolor parameters (<i>L*</i> and <i>a*</i> values) in different feed treatment groups on da... by Wei-Wei Hou (3405947)

Shell colour luminance variation of six phenotypic groups according to background colour and spiral band categories of <i>Polymita muscarum</i>. by Mario Juan Gordillo-Pérez (20565248)

Fig 1 - by Mario Juan Gordillo-Pérez (20565248)

Analysis of stress-related gene expression in cherry shrimp (<i>N</i>. <i>davidi</i> var. red). by Wei-Wei Hou (3405947)

Thermal-dependent product specificity over time. by Gabriel Piedrafita (155328)

“…<p>A total of 800 μM 6PG was incubated at different temperatures in 50 mM phosphate solution pH 5 containing 75 μM cysteine and 75 μM FeCl₂, and the formation of different sugar phosphate products was monitored over time. …”

DataSheet1_Zebrafish EEG predicts the efficacy of antiepileptic drugs.pdf by Jun-Nyeong Shin (14234054)

“…We propose a novel method for pharmacological evaluation of AEDs based on EEG from adult zebrafish, which allows researchers to select more clinically valuable drugs at the early stage of AED screening.…”

Impact of PTGIR agonist on the expression of CP genes in hiPSC-derived monocyte. by Mohamad Karaky (8910497)

Microphotographs of the thyroid gland of female rats and BMD analysis of follicle depletion. by Matti Viluksela (321291)

“…Small circles indicate individual samples, large circles group means; the vertical dotted line indicates the dose (CED) with 5% decrease (CES -0.05) compared to background (a parameter). …”

Histological examination of jejunum specimens. by Raimundo Fernandes de Araújo Júnior (429840)

“…(I) Conversely, reduced inflammation, reepithelization with decreased vasodilatation, decreased cellular infiltration, and reduction of hemorrhagic areas, ulcerations, and abscesses were observed in the jejunum from animals treated with MTX-OLM 5 mg/kg for 3 d. …”

Potent 5‑Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1–UBE2M Interaction by Wenjuan Zhou (115285)

“…After finding a novel inhibitor <b>DC-1</b> with IC₅₀ = 1.2 μM, we performed a series of chemical optimizations, which finally led to the discovery of a potent thiazole containing 5-cyano-6-phenylpyrimidin-based inhibitor <b>DC-2</b> (IC₅₀ = 15 nM). …”

Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (<i>S</i>, <i>Se</i>) and Their Azole Derivatives against Chagas Disease by Mercedes Rubio-Hernández (20036142)

“…Seleno-compounds demonstrated enhanced activity and selenazoles showed a decrease in selenium-associated toxicity. Compound 4-methyl-2-(2-(1-(3-nitrophenyl)­ethylidene)­hydrazineyl)-1,3-selenazole (<i><b>Se</b></i><b>2h</b>) emerged as a promising candidate, and its binding to cruzain was investigated. …”

Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (<i>S</i>, <i>Se</i>) and Their Azole Derivatives against Chagas Disease by Mercedes Rubio-Hernández (20036142)

“…Seleno-compounds demonstrated enhanced activity and selenazoles showed a decrease in selenium-associated toxicity. Compound 4-methyl-2-(2-(1-(3-nitrophenyl)­ethylidene)­hydrazineyl)-1,3-selenazole (<i><b>Se</b></i><b>2h</b>) emerged as a promising candidate, and its binding to cruzain was investigated. …”