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14341
Image_5_Coronavirus Disease 2019-Related Alterations of Total and Anti-Spike IgG Glycosylation in Relation to Age and Anti-Spike IgG Titer.JPEG
Published 2022“…<p>The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been affecting the world since January 2020 and has caused millions of deaths. …”
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14342
The role of sugars, sialic acid binding domain (ΔV) and the mutations R284S, R290S on the binding of Siglec-9-EC to hAOC3.
Published 2016“…<b>(C)</b> Relative binding of Siglec-9-EC (WT), -R284S, -R290S, -ΔV, -R120S, R120S/R284 and–R120S/R290S mutants at concentration of 0.5 μM to immobilized hAOC3 (means of two (R120S based mutants)-three experiments are shown ± SEM). *: p<0.05, **:p<0.01 and ***:p<0.001.…”
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14343
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14344
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14345
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14346
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14347
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14348
Data_Sheet_1_A five-year observational prospective mono-center study of the efficacy of alemtuzumab in a real-world cohort of patients with multiple sclerosis.PDF
Published 2023“…</p>Methods<p>Fifty-one RRMS patients [female = 31; mean age 36 (standard deviation 7.1) years; median expanded disability status scale (EDSS) 2 (interquartile range (IQR) 1.5)] initiating ALZ treatment, were consecutively included. …”
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14349
Sensitivity of the long-term reduction in microfilarial load in individuals under 20 years of age to the assumed rate of decay of vaccine efficacy.
Published 2015“…<p>The mean duration of vaccine prophylactic (against incoming L3 larvae) and therapeutic (against microfilariae) activity is 1/the rate of decay (i.e. 5, 10, 20 and 50 years). …”
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14350
Novel Antagonist of the Type 2 Lysophosphatidic Acid Receptor (LPA<sub>2</sub>), UCM-14216, Ameliorates Spinal Cord Injury in Mice
Published 2022“…Toward validating this receptor as a target in SCI, we have developed a new series of LPA<sub>2</sub> antagonists, among which compound <b>54</b> (UCM-14216) stands out as a potent and selective LPA<sub>2</sub> receptor antagonist (<i>E</i><sub>max</sub> = 90%, IC<sub>50</sub> = 1.9 μM, <i>K</i><sub>D</sub> = 1.3 nM; inactive at LPA<sub>1,3–6</sub> receptors). …”
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14351
Novel Antagonist of the Type 2 Lysophosphatidic Acid Receptor (LPA<sub>2</sub>), UCM-14216, Ameliorates Spinal Cord Injury in Mice
Published 2022“…Toward validating this receptor as a target in SCI, we have developed a new series of LPA<sub>2</sub> antagonists, among which compound <b>54</b> (UCM-14216) stands out as a potent and selective LPA<sub>2</sub> receptor antagonist (<i>E</i><sub>max</sub> = 90%, IC<sub>50</sub> = 1.9 μM, <i>K</i><sub>D</sub> = 1.3 nM; inactive at LPA<sub>1,3–6</sub> receptors). …”
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14352
Image_1_The P2X7 Receptor 489C>T Gain of Function Polymorphism Favors HHV-6A Infection and Associates With Female Idiopathic Infertility.tif
Published 2020“…We show that functional P2X7R increases while its blockade decreases viral load. …”
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14354
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14355
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14356
Synthesis and Biological Evaluation of Peripheral 5HT<sub>2B</sub> Antagonists for Liver Fibrosis
Published 2025“…<b>19c</b> markedly reduced fibrotic deposition, with a decrease in fibrosis stage and area in the CCl<sub>4</sub>-induced liver fibrosis mouse model. …”
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14357
Synthesis and Biological Evaluation of Peripheral 5HT<sub>2B</sub> Antagonists for Liver Fibrosis
Published 2025“…<b>19c</b> markedly reduced fibrotic deposition, with a decrease in fibrosis stage and area in the CCl<sub>4</sub>-induced liver fibrosis mouse model. …”
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14358
DataSheet1_Characterization of the PM2.5 aerosol fraction monitored at a suburban site in south-eastern Italy by integrating isotopic techniques and ion beam analysis.docx
Published 2022“…Using the isotopic markers of carbon and nitrogen by means of the IRMS, we determined values of δ<sup>15</sup>N between 4.5 and 10.6‰, which are consistent with the origin of PM2.5 from anthropic combustion processes and a secondary contribution from vehicular traffic. …”
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14359
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14360
Conformational changes measured by fluorescence correlation spectrometry (FCS).
Published 2017“…Addition of metal ions like copper (Cu<sup>2+</sup>) and manganese (Mn<sup>2+</sup>) as well as depletion of divalent metal ions with EDTA in the presence of 0.02% SDS had a much stronger impact on the aggregation of wt-rPrP than on TetraH>G-rPrP and H95G-rPrP. Data are shown as mean values of last five meanders ± SEM of four to six independent experiments with four replicates each.…”