Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2... by Michael, Brauer

“…Estimates reported represent the mean value across 500 draws from the estimate's distribution, with 95% uncertainty intervals (UIs) calculated as the 2·5th and 97·5th percentile values across the draws. …”
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Transition Metal Substitution Effects on Metal-to-Polyoxometalate Charge Transfer by Elliot N. Glass (1648816)

“…A series of hetero-bimetallic transition metal-substituted polyoxometalates (TMSPs) were synthesized based on the Co^II-centered ligand [Co^IIW₁₁O₃₉]^10–. …”

<i>LSM12</i> posttranscriptionally up-regulates <i>EPAC1</i> expression to sustain the RAN gradient for NCT. by Jongbo Lee (9914603)

“…(D) LSM12 depletion posttranscriptionally decreases <i>EPAC1</i> expression via the 5′ UTR. <i>EPAC1</i> reporter plasmids encoding NLUC were generated as depicted in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001002#pbio.3001002.s007" target="_blank">S7B Fig</a>. …”

Autophagy drives fibroblast senescence through MTORC2 regulation by Monique Bernard (673834)

“…</p> <p><b>Abbreviations</b>: 3-MA: 3-methyladenine; ACTA2: actin, alpha 2, smooth muscle, aorta; AKT1: AKT serine/threonine kinase 1; p-AKT1: AKT1 Ser473 phosphorylation; t-AKT1: total AKT serine/threonine kinase 1; ATG4A: autophagy related 4A cysteine peptidase; ATG7: autophagy gene 7; C12FDG: 5-dodecanoylaminofluorescein Di-β-D-Galactopyranoside; CDKN1A: cyclin dependent kinase inhibitor 1A; CDKN2A: cyclin dependent kinase inhibitor 2A; Ctl: control; DAPI: 4ʹ,6-diamidino-2-phenylindole, dilactate; ECM: extracellular matrix; GSH: L-glutathione reduced; H₂O₂: hydrogen peroxide; HLF: adult human lung fibroblasts; Ho: Hoechst 33342 (2′‐[4‐ethoxyphenyl]‐5‐[4‐methyl‐1‐piperazinyl]‐2.5′‐bi‐1<i>H</i>‐benzimidazole); HSC: hepatic stellate cells; LY: LY294002; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MTORC1/2: mechanistic target of rapamycin kinase complex 1/2; N: normal growth medium; NAC: N-acetyl-L-cysteine; PBS: phosphate-buffered saline; PDGFA: platelet derived growth factor subunit A; PRKCA/PKCα: protein kinase C alpha; PtdIns3K: class III phosphatidylinositol 3-kinase; PTEN: phosphatase and tensin homolog; R: rapamycin; RICTOR: RPTOR independent companion of MTOR complex 2; ROS: reactive oxygen species; RPTOR: regulatory associated protein of MTOR complex 1; SA-GLB1/β-gal: senescence-associated galactosidase beta 1; SGK1: serum/glucocorticoid regulated kinase 1; shRNA: short hairpin RNA; siCtl: control siRNA; siRNA: small interfering RNA; SQSTM1: sequestosome 1; SS: serum-free (serum starvation) medium; TP53: tumor protein p53; TUBA: tubulin alpha; V: vehicle.…”

The long-term impact of early adverse experience on adaptive functioning: a pilot study integrating measures of mental status, nonverbal communication, and heart rate variability by Silvia Bussone (9598529)

OASIS modulates VEGFA promoter activities via the region between –709 and –437 bp. by Hidetaka Miyagi (278075)

“…<p>(A) Schematic diagrams of the deleted reporter constructs from the 6-kbp 5′-upstream promoter of the human VEGFA gene. Five putative CRE-like sites (containing an ACGT core) exist in the 6-kbp VEGFA promoter region. …”

Effects of U0126 on delayed neuronal cell death. by Sara Ellinor Johansson (538782)

“…Values are means ± SEM, n = 5–6 numbers of rats in each group. …”

Contribution of cAMP accumulation and ERK1/2 activation to the ISO-promoted impedance response. by Wayne Stallaert (192209)

“…<p>(<b>A,B</b>) Pre-treatment for 1 hour with the adenylyl cyclase inhibitor, SQ2236 (100 µM, A), or the MEK inhibitor, U0126. (5 µM, B) leads to decreases in the kinetics of the slow ascending phase and the maximum value of ISO-promoted impedance response. …”

Liver tissue viability. by Peter Onody (50458)

“…The data are presented as means+SEM. ¤ <0.05 versus “early” control group; &p<0.05 versus sham-operated group; $ p<0.05 versus “early” IR group; #p<0.05 versus “late” control group; * p<0.05 versus “late” IR group. n = 5 in sham-operated (S) and control groups (C_E, C_L); n = 10 in IR (IR_L, IR_E) and levosimendan pretreated groups (L_E, L_L).…”

Periodontal clinical evaluation before and after surgically assisted rapid maxillary expansion by Michelle Sendyk (5255843)

“…Methods: The clinical attachment level (CAL), gingival recession, attached gingiva and bleeding were evaluated in maxillary first premolars and molars, central and lateral incisors of right and left sides before surgery, 5 days and 6 months after. Means, standard deviation, medians, minimum and maximum values were compared among the evaluations using the Friedman and McNemar tests. …”

The categories of criminal regions and the categories of crime dynamics in cities. by Marcos Oliveira (3462851)

“…Here we used hierarchical clustering with Euclidean distance and define 0.5 as the threshold to segment clusters.</p>…”

miR-147 reverses mesenchymal phenotype. by Chang Gong Lee (509341)

“…MTT assay showed that the OD at 490 nm values of miR-147-transfected HCT116 and SW480 Cells decreased significantly compared to negative control miR transfected cells, (p = 1.9e-5, and p = 0.013 respectively). …”

Comparative Transcriptomics between <i>Synechococcus</i> PCC 7942 and <i>Synechocystis</i> PCC 6803 Provide Insights into Mechanisms of Stress Acclimation by Konstantinos Billis (650319)

“…PCC 6803 are model cyanobacteria from which the metabolism and adaptive responses of other cyanobacteria are inferred. Using stranded and 5′ enriched libraries, we measured the gene expression response of cells transferred from reference conditions to stress conditions of decreased inorganic carbon, increased salinity, increased pH, and decreased illumination at 1-h and 24-h after transfer. …”

Information S1 - Hypoxia Increases Gefitinib-Resistant Lung Cancer Stem Cells through the Activation of Insulin-Like Growth Factor 1 Receptor by Akiko Murakami (515972)

“…Treatment with YC-1 significantly decreased the number of HIF1α-positive cells in a dose-dependent manner. …”

Knock out VGLL4 in valvar endothelial cells leads to hypertrophy and compromised heart function on later stage. by Wei Yu (43094)

“…<p>(A) Gross front view of hearts from 9-month-old <i>Tie2</i>^<i>Cre+</i><i>;Vgll4</i>^<i>fl/-</i> and <i>Vgll4</i>^<i>fl/-</i> control hearts. …”

Larvicidal and macrofilaricidal efficacy of Closantel and Morantel against mosquito larvae and <i>Setaria digitata</i> nematodes by Megan Hall (506400)

“…While malaria incidence in India has decreased by nearly 50% in recent years, India holds 66% of the WHO SEA region’s malaria burden (World Malaria Report, 2023, Singh et al., 2024). …”

Microsatellite Instability and Mistmatch Repair protein analysis by Salvador J. Diaz-Cano (100072)

“…<p>Microsatellite Instability Testing in CRC and Interpretation</p> <p>Microsatellite instability is a type of mutation that occurs in microsatellite regions (short polymorphic DNA segments) by nucleotide addition (increased size) or nucleotide loss (decreased size) in the repeats. …”

Molecular and Peritoneal Microvascular Changes Cause Peritoneal Membrane Dysfunction by Uremia-Related Mechanisms by Zakaria, El-Rasheid

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Image_2_A phytobiotic extract, in an aqueous or in a cyclodextrin encapsulated form, added in diet affects meat oxidation, cellular responses and intestinal morphometry and microbi... by Stella Dokou (14796124)

“…To investigate ileal and cecal bacterial community diversity, 16S rRNA gene high-throughput amplicon sequencing on the V3–V4 hypervariable region was performed. The results showed that the herbal extract in cyclodextrin delayed meat lipid oxidation. …”

Table_1_A phytobiotic extract, in an aqueous or in a cyclodextrin encapsulated form, added in diet affects meat oxidation, cellular responses and intestinal morphometry and microbi... by Stella Dokou (14796124)

“…To investigate ileal and cecal bacterial community diversity, 16S rRNA gene high-throughput amplicon sequencing on the V3–V4 hypervariable region was performed. The results showed that the herbal extract in cyclodextrin delayed meat lipid oxidation. …”