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20721
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20722
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20723
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20724
Plasmid constructs used in this study.
Published 2025“…We found that hypermethylation of the upstream regulatory sequence of PRAME-AS results in an approximately 50% reduction in PRAME transcripts and an 18.5% decrease in PRAME-AS transcript levels. …”
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20725
Oligonucleotides used in this study.
Published 2025“…We found that hypermethylation of the upstream regulatory sequence of PRAME-AS results in an approximately 50% reduction in PRAME transcripts and an 18.5% decrease in PRAME-AS transcript levels. …”
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20726
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20727
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20728
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20729
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20730
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20731
DOT or SAT for Rifampicin-resistant tuberculosis? A non-randomized comparison in a high HIV-prevalence setting
Published 2017“…<div><p>Background</p><p>Daily directly-observed therapy (DOT) is recommended for rifampicin-resistant tuberculosis (RR-TB) patients throughout treatment. We assessed the impact of self-administered treatment (SAT) in a South African township with high rates of RR-TB and HIV.…”
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20732
Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer
Published 2024“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC<sub>50</sub> = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”
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20733
Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer
Published 2024“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC<sub>50</sub> = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”
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20734
Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer
Published 2024“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC<sub>50</sub> = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”
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20735
Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer
Published 2024“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC<sub>50</sub> = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”
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20736
Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer
Published 2024“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC<sub>50</sub> = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”
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20737
Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer
Published 2024“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC<sub>50</sub> = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”
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20738
Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer
Published 2024“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC<sub>50</sub> = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”
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20739
Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer
Published 2024“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC<sub>50</sub> = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”
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20740
Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer
Published 2024“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC<sub>50</sub> = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”