Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”

Overexpression of TNFAIP9 suppressed inflammation in mouse peritoneal macrophages caused by 5/6 Nx in C57 mice. by Ying Chen (9697)

Comparison of autonomic modulation at apnea/hypopnea terminations according to sleep stage: (A) RR intervals (RR), (B) low (LF^WV) and (C) high frequency (HF^WV... by Florian Chouchou (512672)

Human Papillomavirus Infection in a Male Population Attending a Sexually Transmitted Infection Service by Marta Elena Álvarez-Argüelles (276222)

“…</p> <h3>Patients and Samples</h3><p>Between July 2002 and June 2011, 1392 balanopreputial, 435 urethral, 123 anal, and 67 condyloma lesions from 1551 men with a mean age of 35.8±11.3 years old (range: 17–87) were collected for HPV-DNA testing.…”

CA alleviated DOX-induced myocardial injury <i>in vitro</i> and <i>in vivo</i>. by Meijiao Mao (10677555)

Apoptosis inhibitor abolished and restored rTsSPc-disrupted Caco-2 monolayer barrier integrity. by Qi Qi Lu (17721401)

“…<p>Caco-2 cells were pretreated with 120 μM Z-VAD-FMK for 1 h and then incubated with 20 μg/ml rTsSPc for another 12 <b>h. A:</b> Z-VAD-FMK pretreatment increased the rTsSPc-reduced TEER of Caco-2 monolayer. …”

Baseline characteristics of study subjects. by Arlete Gianfaldoni (17655603)

“…To detect LH and FSH pulses, the technique proposed by Santen and Bardin was adopted; therefore, one pulse was defined as a 20% increase in the concentrations as to the preceding point, followed by an important decrease.…”

S1 File - by Arlete Gianfaldoni (17655603)

“…To detect LH and FSH pulses, the technique proposed by Santen and Bardin was adopted; therefore, one pulse was defined as a 20% increase in the concentrations as to the preceding point, followed by an important decrease.…”

Hourly cumulative frequency of LH and FSH pulses. by Arlete Gianfaldoni (17655603)

“…To detect LH and FSH pulses, the technique proposed by Santen and Bardin was adopted; therefore, one pulse was defined as a 20% increase in the concentrations as to the preceding point, followed by an important decrease.…”

Assessment of antioxidative capacity and ROS in HK-2 cells following molybdenum treatment and H₂O₂-induced oxidative stress. by Joo Hong Joun (19287602)

“…<p>(A) A viability assay was performed to determine the cytotoxic extent of molybdenum on HK-2 cells. …”

A Mouse Model for Studying the Clearance of Hepatitis B Virus In Vivo Using a Luciferase Reporter by Sheng-qiang Liang (359591)

PGAM5 knockdown prevented rTsSPc from disrupting Caco-2 monolayer integrity. by Qi Qi Lu (17721401)

Evi1 regulates the expression of other CHD genes during embryonic heart development. by Emilie A. Bard-Chapeau (528581)

“…Genes considered to be mis-regulated in Evi1^δex3/δex3 hearts were increased or decreased in expression by at least three fold in average for all samples of the same time-point. …”

Monobenzyltin Complex C1 Induces Apoptosis in MCF-7 Breast Cancer Cells through the Intrinsic Signaling Pathway and through the Targeting of MCF-7-Derived Breast Cancer Stem Cells... by Somayeh Fani (2967933)

“…<p><b>(A, B) Aldefluor assay of MCF-7 cancer stem cells, (C) western blot analysis of protein markers of the Wnt/β-catenin self-renewal pathway in MCF-7 treated cells with a concentration of 2.5 μg/mL (IC</b>_<b>50</b><b>).…”

Quantification of immunohistochemical staining of oral myofibroblasts using an anti-Ki67 antibody. by Maria Adriana Skeff (670466)