DataSheet_2_Preclinical Evaluation of a Novel Dual Targeting PI3Kδ/BRD4 Inhibitor, SF2535, in B-Cell Acute Lymphoblastic Leukemia.zip by Yongsheng Ruan (4921687)

“…Moreover, SF2535 induced cell cycle arrest and decreased cell counts in B-ALL. Interestingly, SF2535 decreased the mean fluorescence intensity (MFI) of integrin α4, α5, α6, and β1 while increasing MFI of CXCR4, indicating that SF2535 may work through inside-out signaling of integrins. …”

DataSheet_2_Preclinical Evaluation of a Novel Dual Targeting PI3Kδ/BRD4 Inhibitor, SF2535, in B-Cell Acute Lymphoblastic Leukemia.zip by Yongsheng Ruan (4921687)

“…Moreover, SF2535 induced cell cycle arrest and decreased cell counts in B-ALL. Interestingly, SF2535 decreased the mean fluorescence intensity (MFI) of integrin α4, α5, α6, and β1 while increasing MFI of CXCR4, indicating that SF2535 may work through inside-out signaling of integrins. …”

DataSheet_1_Preclinical Evaluation of a Novel Dual Targeting PI3Kδ/BRD4 Inhibitor, SF2535, in B-Cell Acute Lymphoblastic Leukemia.docx by Yongsheng Ruan (4921687)

“…Moreover, SF2535 induced cell cycle arrest and decreased cell counts in B-ALL. Interestingly, SF2535 decreased the mean fluorescence intensity (MFI) of integrin α4, α5, α6, and β1 while increasing MFI of CXCR4, indicating that SF2535 may work through inside-out signaling of integrins. …”

DataSheet_1_Preclinical Evaluation of a Novel Dual Targeting PI3Kδ/BRD4 Inhibitor, SF2535, in B-Cell Acute Lymphoblastic Leukemia.docx by Yongsheng Ruan (4921687)

“…Moreover, SF2535 induced cell cycle arrest and decreased cell counts in B-ALL. Interestingly, SF2535 decreased the mean fluorescence intensity (MFI) of integrin α4, α5, α6, and β1 while increasing MFI of CXCR4, indicating that SF2535 may work through inside-out signaling of integrins. …”

DataSheet1_A mechanistic physiologically based model to assess the effect of study design and modified physiology on formulation safe space for virtual bioequivalence of dermatolog... by J. F. Clarke (14200124)

“…The tested dosing scenarios showed decreased sensitivity for all formulation parameters with a decreased dose. …”

DataSheet1_A mechanistic physiologically based model to assess the effect of study design and modified physiology on formulation safe space for virtual bioequivalence of dermatolog... by J. F. Clarke (14200124)

“…The tested dosing scenarios showed decreased sensitivity for all formulation parameters with a decreased dose. …”

Observer model and human/model behavior for two observers. by Sarit F.A. Szpiro (21094755)

“…<p>(A) A population of tuned sensory neurons encodes motion direction (tuning curves representing the mean stimulus response; Before training - light blue, upper panels; After training – dark blue, inverted, lower panels). …”

DataSheet_1_A Chinese Prescription Yu-Ping-Feng-San Administered in Remission Restores Bronchial Epithelial Barrier to Inhibit House Dust Mite-Induced Asthma Recurrence.pdf by Kaifan Bao (6017810)

Table_2_Acute Stress and an Electrolyte- Imbalanced Diet, but Not Chronic Hypoxia, Increase Oxidative Stress and Hamper Innate Immune Status in a Rainbow Trout (Oncorhynchus mykiss... by Leonardo J. Magnoni (6627971)

“…The dietary challenge was also associated with a decrease in the alternative complement pathway activity (ACH₅₀) in plasma, suggesting an impaired innate immune status in that group. …”

Table_1_Acute Stress and an Electrolyte- Imbalanced Diet, but Not Chronic Hypoxia, Increase Oxidative Stress and Hamper Innate Immune Status in a Rainbow Trout (Oncorhynchus mykiss... by Leonardo J. Magnoni (6627971)

“…The dietary challenge was also associated with a decrease in the alternative complement pathway activity (ACH₅₀) in plasma, suggesting an impaired innate immune status in that group. …”

Table 1_Impact of co-infections and immune responses on clinical severity of human adenovirus 3 and 7 infections in hospitalized children with lower respiratory tract infections: a... by Xiaolin Ma (701778)

“…Immune cell analysis indicated that HAdV-7 infections led to a more pronounced decrease in CD3+ T cells (1596.8 vs 2444.8 cells/l, p=0.042), CD8+ cytotoxic T cells (668.6 vs 774.0 cells/µl, p=0.045), and increased NK cell percentages (11.5% vs 9.0%, p=0.044) compared to HAdV-3 infections.…”

Empirical results from the behavioural online experiment. by James A. R. Marshall (7444412)

“…<p>Decreasing reaction times as a function of the magnitude of the equal alternatives. …”

Table_2_Low Incidence and Mortality by SARS-CoV-2 Infection Among Healthcare Workers in a Health National Center in Mexico: Successful Establishment of an Occupational Medicine Pro... by Miguel Ángel Salazar (10588691)

“…</p><p>Conclusion: INER has a lower incidence of HCWs infected with SARS-CoV-2 as compared to the mean of the national report. …”

Table_1_Low Incidence and Mortality by SARS-CoV-2 Infection Among Healthcare Workers in a Health National Center in Mexico: Successful Establishment of an Occupational Medicine Pro... by Miguel Ángel Salazar (10588691)

“…</p><p>Conclusion: INER has a lower incidence of HCWs infected with SARS-CoV-2 as compared to the mean of the national report. …”

Image 1_Long-term adoption of plow tillage and green manure improves soil physicochemical properties and optimizes microbial communities under a continuous peanut monoculture syste... by Yunfeng Yao (7136525)

“…It was found that both PTGM and PT remarkably decreased the average bulk density (BD), while elevated the mean soil porosity (SP) in 0–30 cm soil layer. …”

Data_Sheet_1_Microbial communities in the liver and brain are informative for postmortem submersion interval estimation in the late phase of decomposition: A study in mouse cadaver... by Linlin Wang (289071)

“…Eighteen taxa in the liver which were mainly related to Clostridium_sensu_stricto and Aeromonas, and 26 taxa in the brain which were mainly belonged to Clostridium_sensu_stricto, Acetobacteroides, and Limnochorda, were selected as potential biomarkers for PMSI estimation based on a random forest algorithm. The PMSI estimation models established yielded accurate prediction results with mean absolute errors ± the standard error of 1.282 ± 0.189 d for the liver and 0.989 ± 0.237 d for the brain.…”

datasheet1_Exploring the Influences of Temperature on “H-Shaped” Glycerol Dialkyl Glycerol Tetraethers in a Stratigraphic Context: Evidence From Two Peat Cores Across the Late Quat... by Xiaotong Tang (10058231)

“…<p>Unusual “H-Shaped” branched and isoprenoidal glycerol monoalkyl glycerol tetraethers (GMGTs, or H-GDGTs) have been found in peat, lake, and ocean sediments. A survey of recent samples from a modern global peat database suggested that there is a relationship between the abundance of H-GDGTs relative to regular GDGTs and temperature. …”

DataSheet_1_Trends in radiotherapy administration in the management of hepatocellular carcinoma: Analysis of a Korean tertiary hospital registry of hepatocellular carcinoma patient... by Bong Kyung Bae (8736945)

“…With the technical developments, the overall survival (OS) of patients who received radiotherapy as initial management increased significantly (5-year OS: from 5.4% to 30.1%), and the OS difference between patients who did and did not receive radiotherapy as initial management significantly decreased (ratio of restricted mean survival time: from 0.383 to 0.544).…”

Prevalence, Risk Factors, and Antibiotic Intervention of Lower Airway <i>Pseudomonas aeruginosa</i> Colonization in Patients with Stable Chronic Obstructive Pulmonary Disease: a Sy... by Yanbing Liu (1450501)

“…Previous exposure to antibiotics and ICSs was associated with increased PA colonization, with odds ratio (OR) values of (OR = 2.85, 95% CI 1.62–5.01) and (OR = 1.89, 95% CI 1.12–3.19), respectively. Exacerbations decreased within the next year after azithromycin treatment (standardized mean difference [SMD] = −0.43, 95% CI −0.77 to −0.10). …”

Phytoplankton scenario and microcystin in water during extreme drought in semiarid tropical water supplies, Northeastern Brazil by A. H. G. Rego (6721646)

“…Our results confirm that conditions of extreme drought and reduction of the volume of the reservoirs influence the composition, biovolume of phytoplankton and water quality, but not the increase of total microcystin in the analysed, although above 1μg-1 registered a significant decrease of water quality in used for human consumption.…”