A Ligand-Based Drug Design. Discovery of 4‑Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2 by Jiawang Liu (1330971)

“…Another target compound, 7,8-pyrano-4-trifluoromethylcoumarin, is found to be a competitive inhibitor, showing high selectivity for the inhibition of P450 1A2 with a <i>K</i>_i of 0.39 μM, 155- and 52-fold lower than its <i>K</i>_i values against P450s 1A1 and 1B1, respectively. …”

Expression analysis in low iron media of putative iron-responsive genes in B728aΔ<i>ecf5</i>, B728aΔ<i>ecf6</i>, and B728aΔ<i>ecf7</i> mutant strains as compared to B728a.<sup>a</s... by Poulami Basu Thakur (389600)

“…Gene expression was normalized to the <i>16s-rRNA</i> and <i>recA</i> internal control genes. Negative values indicate a decrease in expression levels as computed by taking the negative inverse of a fold change value less than 1.…”

Mitochondrial function is impaired in m.547A>T fibroblasts and cybrids. by Thomas M. Connor (3817990)

“…There was a significant decrease in baseline oxygen consumption, and in maximal oxygen consumption following addition of FCCP in both fibroblasts (C) and cybrids (D). …”

Study sample. by Nipaporn Butsing (19470003)

“…One increased National Institute of Health Stroke Scale (NIHSS) score decreased adjusted BI scores by 3.6.</p><p>Conclusion</p><p>The time after discharge, gender, stroke subtype, and stroke severity are significant factors affecting functional outcomes after a stroke. …”

Table_1_IRE1-bZIP60 Pathway Is Required for Nicotiana attenuata Resistance to Fungal Pathogen Alternaria alternata.XLSX by Zhen Xu (92379)

RNA-seq analysis of doxycycline-inducible ATRX knockdown HFFs stimulated with IFN-β. by Anne-Charlotte Stilp (3520415)

Rituximab: A Review in Pemphigus Vulgaris by James E. Frampton (4995257)

“…Approval in the EU and USA was based on data for the subset of patients with newly-diagnosed, previously untreated PV participating in the randomized, controlled RITUX 3 study; rituximab plus short-course prednisone resulted in a>3-fold higher rate of complete remission off prednisone therapy and a>2-fold decrease in the rate of moderate/ severe relapse compared with standard-dose prednisone in this patient subpopulation. …”

Time scale separation parameters <i>ϵ</i>, <i>ϵ</i>′ and <i>μ</i>′ control bimodality, time to memory loss, and reactivation time in the chromatin modification circuit. by Simone Bruno (12359796)

“…In all simulations, <i>ϵ</i> = 1 and <i>μ</i> = 1 (Figs S and T in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1009961#pcbi.1009961.s001" target="_blank">S1 File</a> show different values) and we decrease <i>ϵ</i> by decreasing (similar results can be obtained if we vary as shown in Fig Q in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1009961#pcbi.1009961.s001" target="_blank">S1 File</a>). …”

Whole brain FC matrix (comprising of 100 ROI) defined based on Pearson’s correlation. by Ishita Rai Bansal (13162713)

Whole brain FC matrix (comprising of 100 ROI) based on the coherence. by Ishita Rai Bansal (13162713)

GOT-1 is not a direct substrate of UBR-1. by Jyothsna Chitturi (5094419)

“…<p>A) The total GOT transaminase activity was increased in <i>ubr-1</i> and <i>ubr-1got-2</i> mutants, but decreased in <i>got-1</i> and <i>ubr-1; got-1</i> mutants. …”

Effects of late treatment with ZNS on A53T α-synuclein-induced loss of nigrostriatal neurons. by Shigeki Arawaka (525081)

“…<p>ZNS administration was started 7 days after rAAV-A53T α-synuclein injection, and the treatment was performed until 4 weeks after viral injection. …”

Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies by Brianna D. Mackie (9212677)

“…<b>BM30</b> exhibits over 100-fold selectivity to NTMT1/2 among a panel of 41 MTs, indicating its potential to achieve high selectivity when targeting the peptide substrate binding site of NTMT1/2. …”

Changes of total body weight(A), ovaries(B), uterus(C), vagina and cervix(D), and serum level of FSH(E) and estrogen(F) in treated (Tr) Vs control (Ct) animals at different time po... by Mohsen Ghadami (330178)

“…Bone marrow transplanted animals compare to untreated controls showed 40–50% decrease in serum FSH level (E, P<0.03) and 4–5.5 folds increase in serum estrogen (F, P<0.004) at all time points of experiment.…”

Transcriptomic response to USF depletion and ionizing radiation. by Kimberly S. Bellingham-Johnstun (21714063)

“…Data represents the log2 ratio of RMA-normalized intensity data for each sample relative to the mean of the genotype-matched no IR samples. Red color represents increased expression, blue represents decreased expression and grey denotes no change. …”

Photocatalytic CO Oxidation over Nanoparticulate Au-Modified TiO₂ Aerogels: The Importance of Size and Intimacy by Ashley M. Pennington (4888408)

“…We determine the activity of catalytic carbon monoxide (CO) oxidation as a function of the size of gold nanoparticles (Au NP), their weight loading, and their interfacial intimacy with similarly sized TiO₂ NPs covalently bonded in an aerogel support. …”

SFN suppressed HCV protein expression and RNA replication. by Jung-Sheng Yu (3214659)

“…<p>(A) Structures of SFN and its analogs. (B, C) HCV protein and RNA expression were decreased by SFN treatment in the HCV replicon system. …”

Glutamate level is elevated in <i>ubr-1</i> mutants. by Jyothsna Chitturi (5094419)

“…Levels in mutants were normalized to that of wildtype. A) Glutamate level was increased in <i>ubr-1</i>, but decreased in <i>got-1</i> mutants; the increase in glutamate was reversed in <i>ubr-1; got-1</i>, but not in <i>ubr-1 got-2</i> mutants. …”

Effects of the adenosine A_2A antagonist MSX-3 on PROG/chow performance. by Patrick A. Randall (302096)

“…<p>On measures of lever pressing, mean (±SEM) total lever presses (A) and maximum ratio achieved (B) were both significantly increased at doses of 1.0 and 2.0 mg/kg while active lever time (measured in seconds, C) was only increased at a dose of 2.0 mg/kg. …”

Capacity of the insect AST-A peptides to activate the <i>A</i>. <i>coluzzii</i> GPRALS. by Rute C. Felix (5664397)