Label-free real-time multi-parametric monitoring enables high content analysis. by Heinz-Georg Jahnke (122745)

“…The effect on the APD was determined for one hour after doxorubicin application and revealed a concentration dependent response with an EC₅₀ value of 17 µM (n  = 3 hCMC), (B) The impedance analysis revealed a concentration- and time-dependent decrease where IC₅₀ values could be determined for each time point (n  = 5 hCMC). …”

Transgenerational maintenance of Cid levels. by Nitika Raychaudhuri (109805)

“…<p>Experimentally, centromeric Cid-EGFP levels were either increased (a, b) or decreased (c–g) in sperm in a background producing only Cid-EGFP instead of endogenous Cid. …”

Table_1_orf6 and orf10 in Prophage phiv142-3 Enhance the Iron-Acquisition Ability and Resistance of Avian Pathogenic Escherichia coli Strain DE142 to Serum.DOC by Dezhi Li (288515)

“…DE142Δorf6 showed an obviously attenuated growth rate in the logarithmic phase when cultured in iron-deficient medium, and the transcription level of the iutA gene decreased to 43% (P < 0.05). The bactericidal assays showed that the survival of the mutant DE142Δorf10 was ~60% compared with WT in 50% chicken serum. …”

Resistance to pentamidine is mediated by AdeAB, regulated by AdeRS, and influenced by growth conditions in <i>Acinetobacter baumannii</i> ATCC 17978 by Felise G. Adams (5211146)

“…RNA-sequencing of Δ<i>adeRS</i> revealed transcription of 290 genes were ≥2-fold altered compared to the wildtype. Pentamidine shock significantly increased <i>adeA</i> expression in the wildtype, but decreased it in Δ<i>adeRS</i>, implying that AdeRS activates <i>adeAB</i> transcription in ATCC 17978. …”

Cell survival analysis in <i>PC3/Tis21</i>^−/− and <i>PC3/Tis21</i>^+/+ mice. by Stefano Farioli-Vecchioli (256006)

“…(<b>A</b>) A significant increase of the number of cells undergoing apoptosis was observed in all cells of dentate gyrus (1.6-fold increase) of <i>PC3/Tis21</i>-null mice, and more specifically in (<b>B</b>) type-2b and type-3 progenitor cells, measured as percentage of Caspase-3-DCX-positive and NeuN-negative cells in the population of DCX-positive and NeuN-negative cells (3.2-fold increase). …”

Chronic prostatic inflammation induces elevated autoantibody levels. by Bettina Schlick (849762)

“…<b>C</b> Calculation of the fold change for each autoantibody revealed a significant increase of 165 antigens in high inflammation prostate cancer (upper right panel, p<0.05, fold change>2, Mann-Whitney Test) and a decrease of only one (upper left panel). …”

Cardiac Kallikrein-Kinin System Is Upregulated in Chronic Volume Overload and Mediates an Inflammatory Induced Collagen Loss by Chih-Chang Wei (117683)

“…Treatment with the kallikrein inhibitor aprotinin preserved interstitial collagen, prevented the increase in mast cells, and improved LV systolic function at 4 wk ACF. To establish a cause and effect between ISF bradykinin and mast cell-mediated collagen loss, direct LV interstitial bradykinin infusion <em>in vivo</em> for 24 hrs produced a 2-fold increase in mast cell numbers and a 30% decrease in interstitial collagen, which were prevented by BK₂R antagonist. …”

β-catenin from the cadherin-bound AJ pool translocates to the nucleus. by Yoonseok Kam (267020)

“…(B) LPA-stimulated cells exhibited a steady decrease of AJ expression, coupled with a steady increase of nuclear β-catenin expression, over time. …”

Gene expression in HP and LP MIN6 cells. by Kim Cheng (316047)

“…B) HP MIN6 cells had reduced expressions of the glucose transporter <i>Glut1</i> and the key glycolytic gene <i>Pfk</i>. There was a greater than 2-fold increase in the glycolytic gene <i>Ldh-A</i> in high passage MIN6 cells. …”

Table1_Remagnetization of Carboniferous Limestone in the Zaduo Area, Eastern Qiangtang Terrane, and Its Tectonic Implications.XLSX by Liang Yu (207992)

“…The κ (α₉₅) value decreases (increases) after tilt-correction, and the ChRM directions failed both the McFadden (1990), Watson and Enkin (1993) fold tests, indicating post-folding magnetizations. …”

Table2_Remagnetization of Carboniferous Limestone in the Zaduo Area, Eastern Qiangtang Terrane, and Its Tectonic Implications.XLSX by Liang Yu (207992)

“…The κ (α₉₅) value decreases (increases) after tilt-correction, and the ChRM directions failed both the McFadden (1990), Watson and Enkin (1993) fold tests, indicating post-folding magnetizations. …”

Table3_Remagnetization of Carboniferous Limestone in the Zaduo Area, Eastern Qiangtang Terrane, and Its Tectonic Implications.XLSX by Liang Yu (207992)

“…The κ (α₉₅) value decreases (increases) after tilt-correction, and the ChRM directions failed both the McFadden (1990), Watson and Enkin (1993) fold tests, indicating post-folding magnetizations. …”

Kinases are recruited to the signaling complex by alternative N-t localization domains. by Paloma M. Sato (672126)

“…In most cases, mutations that disrupt specific recruitment interactions decrease pathway activation between 40%–50%. MUT Ste20[N]-Ste50[C] might still localize to the signaling complex, as Ste50's RA domain binds Cdc42 independently of Ste20's PBD domain <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002012#pbio.1002012-Truckses1" target="_blank">[53]</a>. …”

CRT silencing improved FZD-induced injury of mitochondria and cardiomyocytes. by Ming Zhang (9736)

“…When transfected NRCMs were stimulated with 50 µM FZD for 24 h, real-time PCR revealed that CRT silencing significantly inhibited the decrease of MnSOD mRNA expression (E), and western blot was used to determine the protein levels of CRT, phosphorylated and total STAT3, and MnSOD in the whole cell lysates. β-actin was used as a loading control. …”

Map of thermal risk variation, based on the response of lizards to dehydration for <i>Loxopholis percarinatum</i> across the amazon basin. by Agustín Camacho (331354)

“…D represents thermal risk after a 50% decrease in rainfall, E shows risk after a decrease of 20% in tree cover, and F shows the risk for lizards with VTmax = 28.8°C, The median VTmax for <i>L</i>. …”

Effect of <i>INS-19</i> and <i>INS-20</i> gene knockout on the growth of <i>Cryptosporidium parvum</i>. by Yue Huang (285485)

“…At the peak of infection, mice infected with the <i>Δins-19</i> line showed a threefold decrease in fecal luciferase activity compared to those infected with the IId-GFP line, while those infected with the <i>Δins-20</i> line showed a 6-27-fold decrease in fecal luciferase activity. …”

On-Chip Alternating Current Electrophoresis in Supported Lipid Bilayer Membranes by Peng Bao (399943)

“…The reduced scale of the trap structures compared to those previously used in our laboratory has led to over a 10-fold decrease in the operational time require for charge build-up, from 16 h down to 1.5 h. …”

Figure 5 by Michael L. Megison (469463)

“…Data reported as mean fold change in tumor volume ± standard error. In the HuH6 xenografts, there was a significant decrease in tumor growth that began at day 7 following treatment that continued to the end of the study. …”

Ficus arrests the cell cycle in SiHa at G₁/S phase and modulates the expression of cell cycle regulatory proteins. by Amit S. Choudhari (438151)

“…<p>SiHa cells were treated with different concentrations of FR_aq (0–80 µg/ml) for 24 h. (<b>A</b>) Enhanced accumulation of the cells in G₁ phase with a concomitant decrease in S-phase population was observed after treatment with Ficus (as indicated by histograms). …”

Use of GPCR-HIT to show effect of AT₁ receptor activation on CCR2/Gα_i1 proximity. by Mohammed Akli Ayoub (176430)

“…It has been observed previously [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119803#pone.0119803.ref039" target="_blank">39</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119803#pone.0119803.ref041" target="_blank">41</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119803#pone.0119803.ref042" target="_blank">42</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119803#pone.0119803.ref044" target="_blank">44</a>] that the BRET signal can increase or decrease as a consequence of the ligand-induced conformational change associated with Gα_i1 protein activation (A). …”