Inhibiting autophagy reduces retinal degeneration caused by protein misfolding by Jingyu Yao (322837)

“…Mutations in the gene encoding RHO (rhodopsin) are a common cause of autosomal dominant retinitis pigmentosa (adRP), with the Pro23His variant of RHO resulting in a misfolded protein that activates endoplasmic reticulum stress and the unfolded protein response. …”

Combining Virtual Reality Visualization with Ensemble Molecular Dynamics to Study Complex Protein Conformational Changes by Jordi Juárez-Jiménez (1326255)

“…Detailed tests demonstrate that eMD-VR substantially decreases the computational cost of folding simulations of a WW domain, without the need to define collective variables a priori. …”

ISE6 proteins with increased expression associate with pathways for protein production, transport, assembly, and proteolysis. by Jeffrey M. Grabowski (740800)

“…“Fld, Srt, & Deg” is the folding, sorting, and degradation KEGG pathway. <b>**</b> denotes ortholog in human [<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0004180#pntd.0004180.ref019" target="_blank">19</a>]; + denotes human ortholog showing increased expression following HCV infection;—denotes human ortholog showing decreased expression following HCV infection. …”

Data from: Long-Distance Transportation Causes Temperature Stress in the Honey Bee, Apis mellifera (Hymenoptera: Apidae) by Dacotah Melicher (17480604)

“…Functional and enrichment analysis identified increased methylation and decreased ribosomal and protein-folding activity. Pheromone and odorant-binding transcripts were up-regulated after transportation. …”

Differential Effects of Collagen Prolyl 3-Hydroxylation on Skeletal Tissues by Erica P. Homan (249068)

“…These proteins, together with cyclophilin B (encoded by <i>PPIB</i>), form a complex that 3-hydroxylates a single proline residue on the α1(I) chain (Pro986) and has cis/trans isomerase (PPIase) activity essential for proper collagen folding. …”

Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation by Vittoria Massafra (613864)

“…Our analyses provide a resource of FGF19 target proteins in the liver. 189 proteins were upregulated (≥ 1.5 folds) and 73 proteins were downregulated (≤ -1.5 folds) by FGF19. …”

Pharmaceutical films made from the waste material from the preparation of propolis extracts: development and characterization by Lucas de Alcântara Sica de Toledo (12847154)

“…Films were produced in the presence and absence of a polymeric adjuvant (gelatin or ethylcellulose) and propylene glycol by a solvent casting method. …”

Mutation Induced Extinction in Finite Populations: Lethal Mutagenesis and Lethal Isolation by C. Scott Wylie (145239)

“…Next, we perform stochastic population-genetics simulations on a realistic fitness landscape that both (i) features an epistatic distribution of fitness effects that agrees with experimental data on viruses and (ii) is based on the biophysics of protein folding. …”

Schematic of EDR-based model of the cortex. by Szabolcs Horvát (3148731)

“…The interareal distances follow a unimodal (Gaussian-like) distribution <i>q</i>(<i>d</i>) (i.e., <i>q</i>(<i>d</i>)Δ<i>d</i> gives the fraction of interareal distances with lengths between <i>d</i> and <i>d +</i> Δ<i>d</i>), as there are more area pairs separated at medium distances than at long or short distances, an observation valid for both smooth and folded brains (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002512#pbio.1002512.g007" target="_blank">Fig 7C</a>). …”

White matter segmentation across age. by François Leroy (339222)

“…As for infants older than two months old (14 weeks), segmentation performance decreases in a few areas because of on-going maturation, such as along the calcarine sulcus and the central sulcus (<i>yellow arrows</i>).…”

Single-Molecule Kinetic Investigation of Cocaine-Dependent Split-Aptamer Assembly by Frances D. Morris (5860484)

“…Dissociation-time distributions are biexponential, possibly indicating different folded states of the aptamer. The dissociation rate of only the longer-lived complex decreases with cocaine concentration, suggesting that cocaine stabilizes the long-lived aptamer complex. …”

Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor 1 by Lisa M. Ryno (1323840)

“…In metazoans, the heat shock response primarily functions through the posttranslational activation of heat shock factor 1 (HSF1), a stress-responsive transcription factor that induces the expression of cytosolic proteostasis factors including chaperones, cochaperones, and folding enzymes. …”

Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor 1 by Lisa M. Ryno (1323840)

“…In metazoans, the heat shock response primarily functions through the posttranslational activation of heat shock factor 1 (HSF1), a stress-responsive transcription factor that induces the expression of cytosolic proteostasis factors including chaperones, cochaperones, and folding enzymes. …”

Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor 1 by Lisa M. Ryno (1323840)

“…In metazoans, the heat shock response primarily functions through the posttranslational activation of heat shock factor 1 (HSF1), a stress-responsive transcription factor that induces the expression of cytosolic proteostasis factors including chaperones, cochaperones, and folding enzymes. …”

Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor 1 by Lisa M. Ryno (1323840)

“…In metazoans, the heat shock response primarily functions through the posttranslational activation of heat shock factor 1 (HSF1), a stress-responsive transcription factor that induces the expression of cytosolic proteostasis factors including chaperones, cochaperones, and folding enzymes. …”

Single-Molecule Kinetic Investigation of Cocaine-Dependent Split-Aptamer Assembly by Frances D. Morris (5860484)

“…Dissociation-time distributions are biexponential, possibly indicating different folded states of the aptamer. The dissociation rate of only the longer-lived complex decreases with cocaine concentration, suggesting that cocaine stabilizes the long-lived aptamer complex. …”

Data_Sheet_1_Structural Brain Imaging Predicts Individual-Level Task Activation Maps Using Deep Learning.pdf by David G. Ellis (12428781)

“…An ablation study revealed that a model using the shape of the cortex alone or the shape of the subcortical matter alone was sufficient to predict individual-level differences in task activation maps, but a model using the shape of the whole brain resulted in markedly decreased performance. …”

Charge Profile Analysis Reveals That Activation of Pro-apoptotic Regulators Bax and Bak Relies on Charge Transfer Mediated Allosteric Regulation by Crina-Maria Ionescu (158447)

“…Sequence and structural alignment revealed that this hub was conserved in the Bak amino acid sequence, and in the 3D structure of folded Bak. Our results suggest that allostery mediated by charge transfer is responsible for the activation of both Bax and Bak, and that this might be a prototypical mechanism for a fast activation of proteins during signal transduction. …”

<i>svb</i> Controls Denticle Pigmentation through the Regulation of <i>y</i> Transcription by Hélène Chanut-Delalande (274634)

“…<div><p>(A) Cuticle preparations (A3–A4 segments) showing the effect of Ptc-Gal4–driven ectopic expression of <i>svb</i>. …”

Table_1_Refractory Helicobacter pylori infection and the gastric microbiota.docx by Dongsheng Liu (73360)

“…The bacterial interaction network diagram suggested that the microbiota interactions in the refractory H. pylori infection group decreased. The gastric microbiota of the refractory H. pylori infection group was enriched in the pathways of metabolism and infectious diseases (energy metabolism, bacterial secretion system, glutathione metabolism, protein folding and associated processing, sulphur metabolism, membrane and intracellular structural molecules, lipopolysaccharide biosynthesis, ubiquinone and other terpenoid-quinone biosynthesis, inorganic ion transport and metabolism, and metabolism of cofactors and vitamins) when compared with the H. pylori-positive group without treatment based on PICRUSt analysis.…”