Discovery of PMSA Derivative <b>11</b> as a Novel Lead Compound for Therapeutic Treatment of Osteoporosis <i>In Vitro</i> and <i>In Vivo</i> by Zhihao Chen (513264)

“…Additionally, <b>11</b> blocked the formation of F-action belts and bone resorption in a concentration-dependent manner. Mechanistically, <b>11</b> decreased the expression of genes required for osteoclastogenesis by blocking NFATc1 translocation from the cytoplasm to nucleus. …”

Evolved <i>efgA</i> alleles have a variety of predicted folding and binding stabilities. by Jannell V. Bazurto (7847171)

“…<p>We used our MD+FoldX approach [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001208#pbio.3001208.ref079" target="_blank">79</a>] to predict the effect of all possible 19 mutations at each amino acid site on monomers or tetramer formation. …”

Net work vs phase of activation and lattice spacing. Top) We simulated work loops in the half sarcomere model at phases of activation of 0 to 0.95 in 0.05 increments, as well as over lattice spacings from 12 to 18 nm and plotted the new work for each condition. Bottom) We then simulated work loops over the same range, but with the stiffness of either the linear or torsional spring comprising the crossbridge head increased or decreased by 50% separately.... by Travis Carver Tune (21012349)

“…Bottom) We then simulated work loops over the same range, but with the stiffness of either the linear or torsional spring comprising the crossbridge head increased or decreased by 50% separately. …”

The number of Brn3a-expressing cells in retino-collicular co-cultures decreases between DIV4 and DIV12. by Sylvie Voyatzis (332702)

“…(B, C) The density of cells immunoreactive for Brn3a undergoes a reduction of ∼68% between DIV4 and DIV7, and a further decrease of ∼22% between DIV 7 and DIV12. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Jump into a New Fold—A Homology Based Model for the ABCG2/BCRP Multidrug Transporter by Laura László (3221631)

“…The recently published high resolution structure of a close homologue, the ABCG5-ABCG8 heterodimer, revealed a new ABC transporter fold, unique for ABCG proteins. …”

Increased AQP2 expression by a vasopressin analogue is decreased by diphenyleneiodonium. by Eric Féraille (513934)

Growth curves (A, strain AWRI R2 (A); B, strain BH8 (B); C, strain Freddo (F)) and accumulated fermentation system mass loss(D, strain A; E, strain B; F, strain F) of <i>S</i>. <i>... by Xiang-yu Sun (748032)

Mitochondrial protein acetylation correlates with a decrease in sirtuin 3 levels. by Mercedes García-Roche (6459200)

Increased expression of Fz5 receptor matched with a decrease in NeuN immunoreactivity at 16w. by Carlos González-Fernández (2794207)

Schematic representation of the effects of stepwise bromination of the benzene ring of benzotriazole (Bt), including interdependence of the molecular volume (A) and pK_a (B) of the products with their IC₅₀ for inhibition of protein kinase CK2α: (a) Green arrows follow sequential bromination of the central vicinal C(5)/C(6) atoms, leading to a moderate decrease of pK_a and a large decrease in IC₅₀; (b) Red arrows illustrate the lesser effects of bromination of the peripheral C(4)/C(7) atoms, resulting in a significant decrease of pK_a, with virtually no gain in inhibitory activity; (c) Black lines link products with the same number of bromine atoms, but substantially differing in pK_a and IC₅₀, culminating in the di- and tri-brominated derivatives with inhibitory activities comparable to that of TBBt. by Romualda Wąsik (119538)

Metabolites which (A) persistently increased and (B) persistently decreased with smoking. by Charmion I. Cruickshank-Quinn (595143)

“…<p>In panel A, these metabolites continued increasing even after smoking cessation. …”

Effects of specific anti-miRs for the five miRNAss on the IC50 of cisplatin (A) and paclitaxel (B) in Hec1A cells. by Taek Sang Lee (494682)

Ulk2 morphants have a decreased extension/retraction ratio. by Stacey Lee (647217)

Temporal distributions of inscriptions and occupations using uniform 50-years-long timeblocks. by Vojtěch Kaše (6156971)

Resveratrol decreases cell proliferation in a time and dose dependent manner. by Mehtap Kilic Eren (591048)

Development of a cAMP sensor with decreased pH sensitivity. by Katy L. Everett (461878)

Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric <i>in silico</i> ROCOCO trial by Daniëlle B. P. Eekers (5560430)

Average time necessary to disperse 50% of the population introduced (half-life time) in experiments and theoretical simulations, according to the number of woodlice initially intro... by Pierre Broly (228993)