Ivermectin as an adjuvant to anti-epileptic treatment in persons with onchocerciasis-associated epilepsy: A randomized proof-of-concept clinical trial by Michel Mandro (2637532)

“…<div><p>Introduction</p><p>Recent findings from onchocerciasis-endemic foci uphold that increasing ivermectin coverage reduces the epilepsy incidence, and anecdotal evidence suggests seizure frequency reduction in persons with onchocerciasis-associated epilepsy, when treated with ivermectin. We conducted a randomized clinical trial to assess whether ivermectin treatment decreases seizure frequency.…”

Average changes in (A) spontaneous AP firing rate, (B) ATP and (C) cAMP by decreasing CaMKII activity with KN-93 (high-3 µmol/L, low-0.5 µmol/L), AIP (high-10 µmol/L, low-2 µmol/L), or decreasing calmodulin activity by W-7 (high-50 µmol/L, low-20 µmol/L). by Yael Yaniv (162548)

FSS rescues homocysteine-caused the decrease of NO production in cultured HUVECs after the application of A23187. by Cathy W. C. Bi (108697)

Bootstrapped LIWC negative word ratio (LWNR) around the hit date for each hurricane and location. by Krishna Bathina (12883820)

Bootstrapped VADER sentiment around each hurricane and location. by Krishna Bathina (12883820)

Heart specific RNase Z variants show a mild decrease in longevity and locomotor response. by Ekaterina Migunova (15909887)

Erratum: Decrease in Incidence of Bronchopulmonary Dysplasia with Erythropoietin Administration in Preterm Infants: A Retrospective Study by Rayjada N. (4272919)

“…<b><i>Objective:</i></b> To determine whether EPO treatment for AOP was associated with a reduced incidence of BPD in premature infants. …”

Introduction of the F region decreases the amount of extracellular PSMs and increases the amount of extracellular FnbA. by Chikara Kaito (230958)

Thermophoresis-Controlled Size-Dependent DNA Translocation through an Array of Nanopores by Miao Zhang (17216)

“…Large arrays of nanopores can be used for high-throughput biomolecule translocation with applications toward size discrimination and sorting at the single-molecule level. In this paper, we propose to discriminate DNA length by the capture rate of the molecules to an array of relatively large nanopores (50–130 nm) by introducing a thermal gradient by laser illumination in front of the pores balancing the force from an external electric field. …”

Comparison of fold changes in off-rate for gD as a function of protein length (306t vs. 285t). by Tina M. Cairns (4110190)

“…Protein length was tested in the context of both gD1 (A) and gD2 (B). Bars are colored to highlight greater than 5-fold change in rates as in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1006430#ppat.1006430.g007" target="_blank">Fig 7</a>. …”

A decreased expression of Rab4b increased GLUT4 localization at the plasma membrane. by Vincent Kaddai (264976)

Towards Automated Annotation of Benthic Survey Images: Variability of Human Experts and Operational Modes of Automation by Oscar Beijbom (767233)

“…Digital photography enables rapid collection of survey images to meet this need, but the subsequent image annotation is typically a time consuming, manual task. We investigated the feasibility of using automated point-annotation to expedite cover estimation of the 17 dominant benthic categories from survey-images captured at four Pacific coral reefs. …”

IC₅₀ values (mean ±SD in μM) of <i><i>in vitro</i></i> DPPH-radical scavenging properties vs. ascorbic acid and antiinflammation propensities vs. indomethacin of the tes... by MohammedBashar Al-Qazzan (22439236)

Consumption of a high-fat diet decreases membrane associated DAT protein in the ventral striatum. by Jackson J. Cone (388757)

Pre-incubation of SB105-A10 either with HIV-1_IIIb or HIV-1_ada strains inhibits the viral infectivity in dilution assay. by Isabella Bon (467395)

“…<p>HIV-1 strains were incubated for 1 hour at 37°C with SB105-A10 (20 µg/ml; 4.2 µM). Following this incubation the samples were diluted 50-fold to reduce dendrimer concentrations to a level below that at which SB105-A10 significantly inhibits HIV replication and challenged with activated PBMCs. …”

Treatment with a muscarinic receptor agonist, acetylcholine (ACh), alters the expression of microRNAs (miRs) in human colon cancer cells. by Shannon M. Larabee (12770415)

Decreased Interhemispheric Coordination in Treatment-Resistant Depression: A Resting-State fMRI Study by Wenbin Guo (151164)

Neurosphere-derived GFP-expressing cells were cultivated with npMSC or nnMSC conditioned media, on polyornithine-coated dishes by Sabine Wislet-Gendebien (4733)

“…Cultures with npMSC conditioned medium are illustrated in A, B and C. As observed in co-culture conditions, there is a significant increase of the number of GFAP-positive cells and significant decreases of the number of Tuj1-positive cells and O4-positive cells (n = 8, ***Student T test, P < 0.0001). …”

ACT-induced decrease of macrophage adhesion. by César Martín (229306)

Knockdown of NG2 by siRNA results in decreased viability and a reduction in PARP levels. by Frank Maus (792209)