Synthesis and Biological Evaluation of the Thionated Antibacterial Agent Nalidixic Acid and Its Organoruthenium(II) Complex by Rosana Hudej (2051047)

“…While the derivatization caused the antibacterial activity of the ligand against E. coli to decrease, the cytotoxicity of the complex against three cancer cell lines was significantly increased and the inhibitory potency against two enzymes of the cathepsin family was increased by 10-fold.…”

Selection of effective short hairpin constructs against pig myocardin in cell-based assays. by Mario Torrado (341701)

“…Protein load – Amido-Black stained blot after immunodetection. (C) Average fold decrease in levels of MYOCD and SM-marker (ACTA2, MYH11, and TAGLN) proteins in sh-1554-transfected <i>versus</i> sh-scr1-transfected PAOSMCs. …”

TC-1 cell lung metastasis is mediated by the CXCR4 <i>in vivo.</i> by Abdessamad Amine (265831)

“…The lung metastasis indices within each cohort of mice are expressed as fold decrease (+/−SEM) over untreated controls <i>***P</i><0.01. …”

Effect of depuration period on the retention of NPs in <i>C</i>. <i>hippurus</i> following trophic transfer exposure for various durations. by Preyojon Dey (20308215)

“…<p>(A) Superimposed bright field and fluorescence images show the presence of red florescence nanoplastics in <i>C</i>. …”

Flow cytometry analysis of apoptosis. by Igor Santos Fonte Bôa (838040)

“…<p>A) Dot plots showing the apoptosis ratios of kidney cells from Control (n = 4), CIN (n = 6), NAC (n = 6), V10 (n = 4), V100 (n = 4) and V300 (n = 4) groups subdivided into cortex (left panel) and medulla cells (right panel). …”

IL1-β effects on protein expression in lipid raft- and non-lipid raft fractions. by Myriam Chentouf (346845)

“…</p><p>Up or down regulated membrane lipid raft and non lipid raft proteins after IL-1β treatment are presented in relative values recorded for the same proteins expressed in raft and non raft fraction in control condition (no IL-1β treatment). A 2-fold increase or decrease (bold) taken as cut-off value (positive or negative) is considered as significant.…”

Bridging experiment by Michael Mahler (8537)

“…Error bars indicate the -fold standard deviation of the duplicate determinations.…”

The result of applying the OKO method on ecYeastGEM_v8.3.4 model for overproducing 49 native metabolites of <i>S</i>. <i>cerevisiae</i>. by Zahra Razaghi-Moghadam (1426774)

“…The numbers of Kcat that are required to increase and decrease are respectively given in columns H and I, and the sum of fold-changes for Kcats is given in column M.…”

Significant changes (P≤0.05, FC ≥2) of fatty acids in <i>Mesorhizobium</i> N₃₃ exposed to cold. by Abdollah Ghobakhlou (503529)

“…Arrows indicate change in concentration: green-increase, red-decrease. FC =  fold changes; NA =  no significant change.…”

Figure3_Raw CT data by Jessica Binder (11748254)

“…</b>Quantitative real-time PCR analysis showing two folds increase in the mRNA levels of RAB40A, SCGB3A1, TMEFF2, and a fold decrease in FRRS1 in sAD2.1 iPSNs compared to AX0018 control iPSNs. …”

Impaired growth of DC lymphocytes in cell culture. by Larisa Pereboeva (322533)

“…The stimulation index (SI) is calculated as a fold increase in cell number relative to the starting cell number. …”

Air entrainment and pressure drop in low-cost ejectors by DANIEL D. LIMA (10365123)

“…However, when a rotameter was installed at the air line, the head losses resulted in a pronounced decrease (3-fold) in the air entrainment rate. …”

Amino acid residues in J_H6 and RF2 of D3-3 germline gene segments are critical to binding and neutralization of HIV by long HCDR3-containing antibodies PG9 and PG16. by Bryan S. Briney (165782)

“…Residues shown to be critical to binding or neutralization of HIV, defined as ≥10-fold decrease in either binding or neutralization when mutagenized <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0036750#pone.0036750-Pancera1" target="_blank">[5]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0036750#pone.0036750-Pejchal2" target="_blank">[24]</a> are indicated by filled circles.…”

Comparison of ISD to existing methods for chromosome structure inference from single-cell Hi-C data. by Simeon Carstens (3603539)

“…</i> (two versions of SA were tested: a long version based on the default annealing protocol and a short version with ten-fold faster annealing). …”

Autocrine modulation of macropinocytosis by XS52 cells via formation and release of S1P. by Lukasz Japtok (299762)

“…Values of the densitometric analysis are expressed as x-fold decrease of p-Akt formation compared to untreated cells ± SEM from three experiments. …”

Cytochrome <i>c</i> release is inhibited by insulin administration. by Thomas H. Sanderson (479898)

“…After 8 min of ischemia followed by 24 h of reperfusion (R24, n = 5) cytosolic Cyt<i>c</i> increases ∼4 fold (p < 0.05) and there is a trend toward mitochondrial Cyt<i>c</i> decrease (p = 0.08), both indicative of mitochondrial Cyt<i>c</i> release. …”

BCM treatment leads to increase in promoter activity of ROS responsive genes and induction of SOS response. by Anand Prakash (1846540)

“…<p><b>A.</b> Around 2-fold increase in the promoter activity of <i>soxS</i>, <i>katG</i>, <i>ahpC</i>, and <i>oxyR</i> genes was found after BCM treatment. **, <i>P</i> < 0.01. *, <i>P</i> < 0.05. …”

Caffeine effects on embryonic heart function at E9.5 and E12.5 under normoxic and hypoxic (2% O₂) conditions. by Daniela L. Buscariollo (140729)

“…<p>In room air, E9.5 embryos (A) and E12.5 hearts (B) were treated with 200 µM caffeine (E9.5, n = 20; E12.5, n = 17) or vehicle (E9.5, n = 24; E12.5, n = 17) at 15 min, as indicated by arrows. …”

PLK2 inhibition reduces the intensity of nuclear pS129 staining in as little as 30 minutes. by Sara Elfarrash (8159490)

“…A minimum of 30 minutes treatment was sufficient to effectively decrease nuclear pS129 but not remove it completely, as is demonstrated by the increased exposure images on the right. …”

Functional independence and factors that influence it in the scope of home care to elderly people by Alessandra Barbosa Lopes (7576394)

“…Results The elderly sample was composed of a majority feminine (76,3%), widows (57,5%), advanced age (83,36 ± 7,67) and bed rest (50%). …”