Rapa inhibits cell death induced by Cdc13p inactivation. by Haiyan Qi (269936)

“…(B) Time-dependent decrease in cell survival. Cells were treated as described in (A). …”

Supplementary Material for: Distribution of pH Changes in Mouse Neonatal Hypoxic-Ischaemic Insult by Kendall G.S. (4130101)

“…Systemic blood analysis revealed, compared with hypoxia alone, that combined insult caused a 63% decrease in blood glucose (1.3 ± 0.2 m<i>M</i>), a 2-fold increase in circulating lactate (17.7 ± 2.9 m<i>M</i>), a reduction in CO₂ to 1.9 ± 0.1 kPa and a drop in pH (7.26 ± 0.06). …”

MFPred: Rapid and accurate prediction of protein-peptide recognition multispecificity using self-consistent mean field theory by Aliza B. Rubenstein (4172893)

“…We observe robust recapitulation of known specificities for all receptor-peptide complexes, and comparison with other methods shows that MFPred results in equivalent or better prediction accuracy with a ~10-1000-fold decrease in computational expense. …”

Systematic Dissection of the Sequence Determinants of Gene 3’ End Mediated Expression Control by Ophir Shalem (206225)

“…Here, we systematically investigate the sequence determinants of 3’ end mediated expression control by measuring the effect of 13,000 designed 3’ end sequence variants on constitutive expression levels in yeast. By including a high resolution scanning mutagenesis of more than 200 native 3’ end sequences in this designed set, we found that most mutations had only a mild effect on expression, and that the vast majority (~90%) of strongly effecting mutations localized to a single positive TA-rich element, similar to a previously described 3’ end processing efficiency element, and resulted in up to ten-fold decrease in expression. …”

Association between changes in miRNA 3′ nucleotide additions and changes in miRNA abundance. by Emily C. Knouf (434880)

“…The bars display the fold change in a given miRNA isomiR, with the color of the bar indicating the 3′ addition affected. …”

Associations between sedentary behavior level and metabolite measurements. by Kota Fukai (3221151)

“…Linear regression between each metabolite was performed, and p-values for unadjusted and adjusted models are shown. Fold change per one-unit decrease with 95% CI in sitting time level were calculated using the beta of the linear regression analysis of the unadjusted model. …”

Quantifying the Human Cost of Global Warming (Data and Scripts) by Timothy M. Lenton (9965891)

“…Reducing global warming from 2.7 to 1.5 °C results in a ~5-fold decrease in the population exposed to unprecedented heat (MAT ≥29 °C). …”

Membrane fraction of Rac before and after increase in sGDI due to stimulus. by Cibele Vieira Falkenberg (103587)

“…Arrows represent effective trajectories that satisfy the 70% increase in sGDI and 40% decrease in cytosolic Rac. Arrow type for fold increase in dissociation constant between Rac and sGDI in comparison to unphosphorylated GDI (see text): 5, solid; 10, dashed; 100 (B) and 1000 (C), bold (solid and dotted). …”

mRNA expression of <i>C. elegans</i> pde genes, daf-11 gene and pkg-1 gene on the basis of qRT-PCR analysis. by Ulrike Beckert (450918)

“…Please note the different scales of panel A–C. Dashed lines depict 2-fold increase or decrease in mRNA expression compared to wild-type.…”

Anti-bacterial activity assay. by Thibault Corneloup (16293971)

“…As all tested strains are Zeocin sensitive, the plating reveals therefore the density of K12::ZeoR in the mix. K12 is used as a control and lead to a high density of K12::ZeoR in the culture, while IAIA14 known for its toxicity to K12, eradicate almost fully K12::ZeoR as illustrated by the absence or very low density of K12::ZeoR. 536 decrease the density of K12:: ZeoR by three orders of magnitude while HS has no impact.…”

DSS-induced colitis mouse model. by William C. Reisdorf (6616148)

“…Experimental groups were: Sham = vehicle control (no DSS or other treatment, n = 6), DSS = DSS-only (n = 12), CsA = 10 mg/kg i.p. treatment (n = 6), EPHX2i = GSK1910364A 50 mg/kg orally, twice daily (n = 6). …”

Intense reelin IR neurons synthesize reelin whereas punctate reelin IR neurons are characterized by the presence of receptor-bound reelin. by Cecilia Gonzalez Campo (264260)

“…GST-RAP was used at 25, 40 and 50 µg/ml. A significant decrease of punctate reelin IR was observed with 40 and 50 µg/ml of GST-RAP (4.5±1.5% and 3.1±0.7%; n = 3 and 3) whereas no effect was detected with a concentration of 25 µg/ml compared to untreated (22.2±1.4% and 21.3±2.2%; n = 3 and 3; F_(3,8) = 45.7, ***P<0.001). …”

Effect of TCERG1 knockdown on Fas-mediated apoptosis. by Marta Montes (812749)

“…Control and TCERG1 knockdown (KD) Jurkat cells were incubated in the absence (-) or presence (+) of 50 ng/ml of anti-Fas/CD95 for 6 h. The percentage of viable cells was measured by a luminometric assay. …”

BPLF1 regulates the expression and activity of TOP2 in productively infected LCLs. by Jinlin Li (2267896)

“…<p>The productive virus cycle was induced by treatment with 1.5 μg/ml Dox in LCL cells carrying recombinant EBV encoding wild type or catalytic mutant BPLF1 and a tetracycline regulated BZLF1 transactivator. …”

hPaf1 is required for expression of the HAdV E2e, E3 and E4 genes during infection and chromatin marks associated with active gene expression. by Gregory J. Fonseca (421739)

“…ChIP was then performed using antibodies specific for trimethylated H3K4 or H3K79 and qRT-PCR was performed for the indicated HAdV early gene promoter region. A statistically significant decrease from Ctrl siRNA treatment is indicated (* P<0.01). n = 3.…”

VPA and NAM treatment modulates H3K27 acetylation at the promoters of myeloid specific genes. by Marije Bartels (532852)

“…Data represent a Venn diagram comparing the number of genes identified based on a >2-fold increase or decrease in H3K27 acetylation levels compared to the control (A). …”

Early isolates of HIV-1 from the blood are deficient in binding and/or fusion with CD4 from some primate species. by Cody J. Warren (563898)

“…Values above error bars represent fold decrease relative to human CD4 for those samples that passed significance thresholds (one-way ANOVA for repeated measures effect, Dunnett’s test; <i>P</i> < 0.05). …”

<i>IL23R</i> gene variants modulate intestinal DMBT1 expression. by Julia Diegelmann (107830)

“…Column (5) summarizes the data from column (3) and represents the fold increase or decrease in DMBT1 expression in carriers of the <i>IL23R</i> minor allele (homozygous and heterozygous) compared to DMBT1 levels in <i>IL23R</i> wild-type carriers for the respective <i>IL23R</i> SNP. …”

Mathematical model describing nucleosomal occupancy. by Barbara Celona (216140)

“…<p>(A) Affinity model based on saturation of nucleosomal sites. …”

Effect of the lytic enzyme PeiR on M1 growth <i>in vitro</i>. by Sinead C. Leahy (244590)