ToxR negatively regulates VSP-1 encoded genes affecting host colonization. by Misha I. Kazi (3174750)

“…(B) Competition assays of ΔVC0176 mutant vs. wild type <i>in vitro</i> and <i>in vivo</i> in the infant mouse model. Each point represents an individual mouse result. ΔVC0176 has a colonization defect vs. wild type <i>in vivo</i> in the infant mouse model compared to <i>in vitro</i>. …”

Six Year Refractive Change among White Children and Young Adults: Evidence for Significant Increase in Myopia among White UK Children by Sara J. McCullough (846708)

“…The proportion of myopes in the UK has more than doubled over the last 50 years in children aged between 10–16 years and children are becoming myopic at a younger age. …”

Image_2_Toward Assessing Farm-Based Anaerobic Digestate Public Health Risks: Comparative Investigation With Slurry, Effect of Pasteurization Treatments, and Use of Miniature Biorea... by Stephen Nolan (5539115)

“…For comparison, FIB survival in slurry was examined and after 60 days of storage, none of the FIB tested was <1,000 cfu g⁻¹, suggesting that slurry would not be considered safe for land application if FIB thresholds required for AD digestate were to be applied. Taken together we demonstrate that (i) miniature-scale bioreactors are valid proxies of farm-based AD to carry out targeted pathogen survival studies and (ii) in situ AD treatment of slurry prior to land application reduces the level of FIB, independently of pasteurization, which in turn might be indicative of a decreased potential pathogen load to the environment and associated public health risks.…”

Image_3_Toward Assessing Farm-Based Anaerobic Digestate Public Health Risks: Comparative Investigation With Slurry, Effect of Pasteurization Treatments, and Use of Miniature Biorea... by Stephen Nolan (5539115)

“…For comparison, FIB survival in slurry was examined and after 60 days of storage, none of the FIB tested was <1,000 cfu g⁻¹, suggesting that slurry would not be considered safe for land application if FIB thresholds required for AD digestate were to be applied. Taken together we demonstrate that (i) miniature-scale bioreactors are valid proxies of farm-based AD to carry out targeted pathogen survival studies and (ii) in situ AD treatment of slurry prior to land application reduces the level of FIB, independently of pasteurization, which in turn might be indicative of a decreased potential pathogen load to the environment and associated public health risks.…”

Image_1_Toward Assessing Farm-Based Anaerobic Digestate Public Health Risks: Comparative Investigation With Slurry, Effect of Pasteurization Treatments, and Use of Miniature Biorea... by Stephen Nolan (5539115)

“…For comparison, FIB survival in slurry was examined and after 60 days of storage, none of the FIB tested was <1,000 cfu g⁻¹, suggesting that slurry would not be considered safe for land application if FIB thresholds required for AD digestate were to be applied. Taken together we demonstrate that (i) miniature-scale bioreactors are valid proxies of farm-based AD to carry out targeted pathogen survival studies and (ii) in situ AD treatment of slurry prior to land application reduces the level of FIB, independently of pasteurization, which in turn might be indicative of a decreased potential pathogen load to the environment and associated public health risks.…”

Illustrative cases of fractionated radiosurgery for large brain metastases. by Joo Whan Kim (3135003)

“…<p>A 50-year-old woman was diagnosed with brain metastases 4 years after treatment for breast cancer. …”

Characterization of the Human Myocardial Proteome in Inflammatory Dilated Cardiomyopathy by Label-free Quantitative Shotgun Proteomics of Heart Biopsies by Elke Hammer (443358)

“…Mass spectrometric data were analyzed with the Rosetta Elucidator software package. The analysis covered a total of 485 proteins. Among the 174 proteins displaying at least a 1.3-fold change in intensity (<i>p</i> < 0.05), major changes were observed for mitochondrial and cytoskeletal proteins, but also metabolic pathways were affected in iDCM compared to controls. …”

Characterisation of FP–protein complexes in replacement stable cell lines by Quantitative SILAC Proteomic analysis. by Motoharu Ono (259551)

“…The bait, UBF1, is shown in red, and a blue line separates the proteins whose interaction with UBF1 is increased (above the line)/or decreased (below) after Actinomycin-D treatment. …”

Mutation rates across 60 <i>C</i>. <i>elegans</i> genotypes stratified by mutation type: Base substitutions, indels, and structural variants. by Bettina Meier (274833)

“…Error bars show the 95% confidence intervals; large dots represent variants with 2-fold increased or decreased mutation rates over N2 wild-type which are statistically significant with a false discovery rate (FDR) below 5%. …”

Supplementary Material for: Association of Phosphate Containing Solutions with Incident Hypophosphatemia in Critically Ill Patients Requiring Continuous Renal Replacement Therapy by ThompsonBastin M.L. (10722348)

“…<b><i>Background:</i></b> Hypophosphatemia in critically ill patients is a common electrolyte disturbance associated with a myriad of adverse effects. …”

Table_1_Psoriasis Is Associated With Elevated Gut IL-1α and Intestinal Microbiome Alterations.XLSX by Sergey Yegorov (176376)

“…Background<p>Psoriasis is a chronic inflammatory condition that predominantly affects the skin and is associated with extracutaneous disorders, such as inflammatory bowel disease and arthritis. …”

DataSheet_2_Enhanced Production of D-Lactate in Cyanobacteria by Re-Routing Photosynthetic Cyclic and Pseudo-Cyclic Electron Flow.pdf by Tiago Toscano Selão (8380095)

“…The Δpgr5 background seemed to be particularly beneficial at 25°C and 0.04% (v/v) CO₂, with a nearly 7-fold increase in D-lactate accumulation in comparison to the wild-type background (≈1000 vs ≈150 mg/L) and decreased side effects in comparison to the flv deletion strains. …”

Intestinal Resident Yeast <em>Candida glabrata</em> Requires Cyb2p-Mediated Lactate Assimilation to Adapt in Mouse Intestine by Keigo Ueno (206625)

“…The Δ<em>cyb2</em> mutant showed 100-fold decreased adaptation and few cells of <em>Saccharomyces cerevisiae</em> can adapt in mouse ceca. …”

The upstream signaling to Nrf1 and proteasome are to no or fewer degrees, affected in <i>SREBP1</i>-deficient cells. by Keli Liu (5937368)

“…(D) The mRNA levels of those examined genes were determined by real-time qPCR and shown as fold changes (mean ± S.D. n = 3×3) with significant decreases (*, <i>p</i><0.01) or significant increases ($, <i>p</i><0.01) relative to equivalent controls. …”

Hemolymph of triatomines presents fungistatic activity against Cryptococcus neoformans and improves macrophage function through MCP-I/TNF-α increase by Luísa Menezes-Silva (13117280)

“…In addition, when these cells were stimulated with hemolymph in the presence of C. neoformans, a 2- and a 4-fold increase in phagocytic rate was observed with MPH and RPH, respectively, when compared to untreated cells. …”

Image_2_Field Relevant Variation in Ambient Temperature Modifies Density-Dependent Establishment of Plasmodium falciparum Gametocytes in Mosquitoes.tif by Ashutosh K. Pathak (7870094)

“…Anopheles stephensi were challenged with three densities of P. falciparum gametocytes spanning a ~10-fold gradient, and housed under diurnal/daily temperature range (“DTR”) of 9°C (+5°C and −4°C) around means of 20, 24, and 28°C. …”

Characterization of the Human Myocardial Proteome in Inflammatory Dilated Cardiomyopathy by Label-free Quantitative Shotgun Proteomics of Heart Biopsies by Elke Hammer (443358)

“…Mass spectrometric data were analyzed with the Rosetta Elucidator software package. The analysis covered a total of 485 proteins. Among the 174 proteins displaying at least a 1.3-fold change in intensity (<i>p</i> < 0.05), major changes were observed for mitochondrial and cytoskeletal proteins, but also metabolic pathways were affected in iDCM compared to controls. …”

CD40 knockdown and CD40-luciferase assay in BL2 cells. by Gang Li (34549)

“…(B) RNAi perturbation of <i>CD40</i> in two distinct clones derived from BL2 cells decreases CD40 protein levels by 55% (left) and 40% (middle) compared to the BL2 parent line (black, right); (C) More CD40 on the surface of BL2 cells increases RelA (p65) phosphorylation following activation with tCD40L, as measured by Western blot, with maximum activation at 15 minutes. …”

Table_3_Field Relevant Variation in Ambient Temperature Modifies Density-Dependent Establishment of Plasmodium falciparum Gametocytes in Mosquitoes.docx by Ashutosh K. Pathak (7870094)

“…Anopheles stephensi were challenged with three densities of P. falciparum gametocytes spanning a ~10-fold gradient, and housed under diurnal/daily temperature range (“DTR”) of 9°C (+5°C and −4°C) around means of 20, 24, and 28°C. …”

Data_Sheet_1_Psoriasis Is Associated With Elevated Gut IL-1α and Intestinal Microbiome Alterations.PDF by Sergey Yegorov (176376)

“…Background<p>Psoriasis is a chronic inflammatory condition that predominantly affects the skin and is associated with extracutaneous disorders, such as inflammatory bowel disease and arthritis. …”