Model-Driven Redox Pathway Manipulation for Improved Isobutanol Production in <i>Bacillus subtilis</i> Complemented with Experimental Validation and Metabolic Profiling Analysis by Haishan Qi (547562)

“…As expected, NADPH pool size in BSUL07 was 4.4-fold higher than that in parental strain BSUL05. …”

DataSheet_1_Single-Cell RNA Sequencing Reveals the Immunological Profiles of Renal Allograft Rejection in Mice.pdf by Qixia Shen (11170275)

“…Both B cells and neutrophils decreased by about 3 folds. On the contrary, the proportion of macrophages and dendritic cells (DCs) increased significantly, especially by about a 4.5-fold increase in Ly6c^loMrc1⁺ macrophages and 2.6 folds increase in Ly6c^loEar2⁺ macrophages. …”

Increased water intake reduces long-term renal and cardiovascular disease progression in experimental polycystic kidney disease by Priyanka S. Sagar (6169736)

“…Increasing water intake reduces renal cyst growth in the <i>pck</i> rat (a genetic ortholog of autosomal recessive PKD) but it is not clear if this beneficial effect is present in other models of PKD. …”

Image_1_Methods of Selenium Application Differentially Modulate Plant Growth, Selenium Accumulation and Speciation, Protein, Anthocyanins and Concentrations of Mineral Elements in... by Qing Xia (114230)

“…Deficiency and suboptimality of Se in human populations are a potential health risk. The reduction of such health risk by biofortification of crops, particularly in wheat has drawn much attention, especially for color-grained wheat as it is rich in anthocyanins and can be used as a major source of antioxidants in diet. …”

Image_2_Methods of Selenium Application Differentially Modulate Plant Growth, Selenium Accumulation and Speciation, Protein, Anthocyanins and Concentrations of Mineral Elements in... by Qing Xia (114230)

“…Deficiency and suboptimality of Se in human populations are a potential health risk. The reduction of such health risk by biofortification of crops, particularly in wheat has drawn much attention, especially for color-grained wheat as it is rich in anthocyanins and can be used as a major source of antioxidants in diet. …”

Data Sheet 1_Non-targeted metabolomics-mediated elucidation of metabolite changes in Polygonatum kingianum during traditional steaming with black beans.zip by Haiyan Zhu (110483)

“…Compared to the raw PK, the P3 stage exhibited significant increases in saponins, total sugars, organic acids, and flavonoids by 21.29, 35.02, 49.13, and 44.76%, respectively (p < 0.05), reducing sugars showed a remarkable increase of 160.94-fold (p < 0.01), while polysaccharides decreased significantly by 43.33% (p < 0.01).…”

Image_4_Transgenic tobacco plant overexpressing ginkgo dihydroflavonol 4-reductase gene GbDFR6 exhibits multiple developmental defects.tif by Jun Ni (68173)

“…<p>Dihydroflavonol Q 4-reductase (DFR), a key enzyme in the flavonoid biosynthetic pathway in plants, significantly influences plant survival. …”

Table_5_Comparison of the Vaginal Microbiomes of Premenopausal and Postmenopausal Women.PDF by Karol Gliniewicz (3538301)

“…The vaginal communities of most postmenopausal women receiving HT (10/15) were dominated by species of lactobacilli and belonged to clusters A, C, and F (P < 0.001). This sharply contrasts with vaginal communities of postmenopausal women without HT, most of which (10/15) were in cluster D, depleted of lactobacilli, and had about 10-fold fewer total bacteria (P < 0.05). …”

Table_3_Transgenic tobacco plant overexpressing ginkgo dihydroflavonol 4-reductase gene GbDFR6 exhibits multiple developmental defects.xlsx by Jun Ni (68173)

“…<p>Dihydroflavonol Q 4-reductase (DFR), a key enzyme in the flavonoid biosynthetic pathway in plants, significantly influences plant survival. …”

<i>TFOFinder</i> program flowchart. by Atara Neugroschl (16884406)

“…For example, triplex-forming peptide nucleic acid (PNA) oligomers have been used for imaging a structured RNA in cells and inhibiting influenza A replication. …”

Table_4_Comparison of the Vaginal Microbiomes of Premenopausal and Postmenopausal Women.PDF by Karol Gliniewicz (3538301)

“…The vaginal communities of most postmenopausal women receiving HT (10/15) were dominated by species of lactobacilli and belonged to clusters A, C, and F (P < 0.001). This sharply contrasts with vaginal communities of postmenopausal women without HT, most of which (10/15) were in cluster D, depleted of lactobacilli, and had about 10-fold fewer total bacteria (P < 0.05). …”

K70Q Adds High-Level Tenofovir Resistance to “Q151M Complex” HIV Reverse Transcriptase through the Enhanced Discrimination Mechanism by Atsuko Hachiya (233188)

“…We have isolated from a TFV-DF-treated HIV patient a Q151Mc-containing clinical isolate with high phenotypic resistance to TFV-DF. …”

Table_2_Transgenic tobacco plant overexpressing ginkgo dihydroflavonol 4-reductase gene GbDFR6 exhibits multiple developmental defects.xlsx by Jun Ni (68173)

“…<p>Dihydroflavonol Q 4-reductase (DFR), a key enzyme in the flavonoid biosynthetic pathway in plants, significantly influences plant survival. …”

Data_Sheet_1_Dynamism of Metabolic Carbon Flow of Starch and Lipids in Chlamydomonas debaryana.pdf by Naoki Sato (78889)

“…Most fatty acids showed rapid and slow components of metabolism, whereas oleic acid decayed according to a single exponential curve. Highly labeled population of fatty acids that accumulated during the initial labeling decreased rapidly, and replaced by low abundance population during the chase time, indicating that highly labeled fatty acids were degraded and the resulting carbons were re-used in the re-synthesis with about 9-fold unlabeled, newly fixed carbons. …”

The extracellular matrix proteoglycan fibromodulin is upregulated in clinical and experimental heart failure and affects cardiac remodeling by Kine Andenæs (5566217)

“…Fibromodulin was 3-10-fold upregulated in hearts of heart failure patients and mice. …”

Activation of the Canonical Wnt/β-Catenin Pathway in ATF3-Induced Mammary Tumors by Leqin Yan (231387)

“…Several positive-acting ligands for this pathway, including <em>Wnt3</em>, <em>Wnt3a</em>, <em>Wnt7b</em>, and <em>Wnt5a</em>, are significantly overexpressed in tumor tissue, and mRNA for <em>Wnt3</em> is about 5-fold more abundant in transgenic mammary tissue than in non-transgenic mammary tissue. …”

Image_1_Coenzyme Q10 or Creatine Counteract Pravastatin-Induced Liver Redox Changes in Hypercholesterolemic Mice.PDF by Ana C. Marques (149564)

“…We observed that pravastatin induced higher H₂O₂ production rate (40%), decreased activity of aconitase (28%), a superoxide-sensitive Krebs cycle enzyme, and increased susceptibility to Ca²⁺-induced MPT (32%) in liver mitochondria. …”

Image_1_Transgenic tobacco plant overexpressing ginkgo dihydroflavonol 4-reductase gene GbDFR6 exhibits multiple developmental defects.tif by Jun Ni (68173)

“…<p>Dihydroflavonol Q 4-reductase (DFR), a key enzyme in the flavonoid biosynthetic pathway in plants, significantly influences plant survival. …”

Bioactive constituents of <i>Salvia przewalskii</i> and the molecular mechanism of its antihypoxia effects determined using quantitative proteomics by Yafeng Wang (330852)

“…In addition, a total of 28 proteins were differentially expressed in lung of hypoxia + SPM group (fold change > ± 1.2 and <i>p</i> < 0.05). …”

Climbing ability of teneral and sclerotized adult bed bugs and assessment of adhesive properties of the exoskeletal fluid using atomic force microscopy by Kevin R. Hinson (4688446)

“…Using atomic force microscopy (AFM), we found that adhesion force of an exoskeletal (presumably molting) fluid decreased almost five-fold from 88 to 17 nN within an hour of molting. …”