Evolutionary Conservation and Diversification of Puf RNA Binding Proteins and Their mRNA Targets by Gregory J. Hogan (160970)

“…<div><p>Reprogramming of a gene’s expression pattern by acquisition and loss of sequences recognized by specific regulatory RNA binding proteins may be a major mechanism in the evolution of biological regulatory programs. …”

Effects of acute Theiler’s murine encephalomyelitis virus (TMEV)-infection (<i>experiment I</i>) upon cytokine expression and phenotypical changes in spleens of interleukin-10 rece... by Ann-Kathrin Uhde (3110976)

“…(J) Flow cytometry revealed a relative increase of CD19⁺ B cells and a simultaneous decrease of CD4⁺ T cells (K) in the spleen of infected mice following IL-10R blockade at 14 dpi. …”

109-virus panel neutralization results. by Collin Joyce (16469212)

“…<p>(top) Neutralization IC₅₀ for PC39-1 Abs for each virus, together with serum ID₅₀ (right column) for the same viruses, colored as indicated in the key. …”

Differential mRNA expression of key metabolic and stress response genes in the <i>MYH7</i> Q315R mice. by Shinya Takarada (8655066)

“…Clustering maps show significant changes in RNA expression (p < 0.05) greater than twofold or less than −2.0-fold (A and C). Scatter plots depict RNA changes, with red dots indicating increased expression and blue dots indicating decreased expression (B and D). …”

Data_Sheet_1_Identification of key factors driving inflammation-induced sensitization of muscle sensory neurons.pdf by Sridevi Nagaraja (833270)

“…Moreover, we found that simulating single knockouts of transient receptor potential ankyrin 1 (TRPA1) and reducing the rates of G_αq-coupled receptor phosphorylation and G_αq subunit activation considerably altered the excitability of nociceptors (i.e., each modification increased or decreased the inflammation-induced fold change in the number of triggered APs compared to when all channels were present). …”

Cerebrovascular gene expression in spontaneously hypertensive rats by Anne-Sofie Grell (670281)

“…The following genes with a fold difference ≥1.40 were verified by quantitative PCR; <i>Postn</i>, <i>Olr1</i>, <i>Fas</i>, <i>Vldlr</i>, <i>Mmp2</i>, <i>Timp1</i>, <i>Serpine1</i>, <i>Mmp11</i>, <i>Cd34</i>, <i>Ptgs1</i> and <i>Ptgs2</i>. …”

KLF4 is required for suppression of histamine synthesis by polyamines during bone marrow-derived mast cell differentiation by Kazuhiro Nishimura (713297)

“…Moreover, the cells showed a 2.3-fold increase in intracellular histamine and up-regulation of histidine decarboxylase (HDC) at the transcriptional level during BMMC differentiation. …”

Peroxide-induced disruption of secondary biochemical pathways. by Carlo Giannangelo (8053910)

“…Pathway enrichment analysis showing the percentage of significantly perturbed metabolites (Welch’s <i>t</i> test; P<i>-</i>value < 0.05 and fold change > 1.5) as a function of metabolite class for extended (3, 6 and 9 h) exposure with OZ277, OZ439 (both 300 nM) and DHA (100 nM). …”

EMILIN2 Regulates Platelet Activation, Thrombus Formation, and Clot Retraction by Menggui Huang (473596)

“…<div><p>Thrombosis, like other cardiovascular diseases, has a strong genetic component, with largely unknown determinants. …”

Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not? by Styliani Fragki (10691290)

“…<p>Associations between per- and polyfluoroalkyl substances (PFASs) and increased blood lipids have been repeatedly observed in humans, but a causal relation has been debated. Rodent studies show reverse effects, i.e. decreased blood cholesterol and triglycerides, occurring however at PFAS serum levels at least 100-fold higher than those in humans. …”

<i>PRS1</i> affects <i>An. gambiae</i> infection with <i>Plasmodium</i>. by Thomas Chertemps (246228)

“…<p>A. Effects of dsRNA injection on <i>PRS1</i> expression in the midgut and the salivary glands. …”

Data_Sheet_1_Differences in Sodium Channel Densities in the Apical Dendrites of Pyramidal Cells of the Electrosensory Lateral Line Lobe.pdf by Sree I. Motipally (6792782)

“…<p>Heterogeneity of neural properties within a given neural class is ubiquitous in the nervous system and permits different sub-classes of neurons to specialize for specific purposes. …”

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction by John D. Belcher (190588)

“…A single infusion of haptoglobin or hemopexin (± equimolar hemoglobin) in SS-mice increased heme oxygenase-1 (HO-1) in the liver, kidney and skin several fold within 1 hour and decreased nuclear NF-ĸB phospho-p65, and vaso-occlusion for 48 hours after infusion. …”

3,3′-Diindolylmethane Induces G₁ Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells by Lyndsey E. Shorey (171162)

“…Taken together, our results demonstrate a potential for therapeutic application of DIM in T-ALL.…”

PARP-1 Expression is Increased in Colon Adenoma and Carcinoma and Correlates with OGG1 by Tomasz Dziaman (677130)

“…PARP-1 and OGG1 proteins level was several fold higher in polyps and CRC in comparison to normal colon tissues. …”

Figure 4 from P4HA1 Mediates Hypoxia-Induced Invasion in Human Pancreatic Cancer Organoids by Bernat Navarro-Serer (21450536)

“…<p>Knockdown of P4HA1 decreases invasion in PDAC PDOs in hypoxia. <b>A,</b> Expression level of P4HA1 measured by qRT-PCR. …”

Inhibition of diverse spike-mediated cell-cell fusion by isolated nanobodies. by Haodi Dong (4390237)

“…</b> The potency and breadth of the top 5 isolated nanobodies and control antibodies in inhibiting cell-cell fusion mediated by a panel of 20 spike variants. Numbers indicate the nanobody and antibody concentrations (μg/ml) required to achieve 50% (IC50) reduction in cell-cell fusion. …”

DataSheet1_Low-Order Scaling Quasiparticle Self-Consistent GW for Molecules.pdf by Arno Förster (11381271)

“…We demonstrate the computational efficiency of the new implementation by calculating the quasiparticle spectrum of a DNA oligomer with 1,220 electrons using a basis of 6,300 atomic orbitals in less than 4 days on a single compute node with 16 cores. …”

Image_4_Duplex droplet digital PCR detection of Streptococcus uberis and Streptococcus dysgalactiae, major etiological agents of bovine mastitis.pdf by Leticia Diana (472099)

“…Indeed the detection limit for cultures and mock samples for dddPCR was a hundred times lower than the endpoint PCR. Additionally, the CFU/mL estimated based on the number of copies/uL obtained through dddPCR exhibited a strong correlation with the observed CFU/mL from the culture (r^2 > 0.99, p-value < 0.001), indicating that dddPCR provides a dependable estimate of this parameter. …”

Image_1_Duplex droplet digital PCR detection of Streptococcus uberis and Streptococcus dysgalactiae, major etiological agents of bovine mastitis.pdf by Leticia Diana (472099)

“…Indeed the detection limit for cultures and mock samples for dddPCR was a hundred times lower than the endpoint PCR. Additionally, the CFU/mL estimated based on the number of copies/uL obtained through dddPCR exhibited a strong correlation with the observed CFU/mL from the culture (r^2 > 0.99, p-value < 0.001), indicating that dddPCR provides a dependable estimate of this parameter. …”