Meta-analysis of 3 manipulations of the insulin/Tor signaling identifies rover-biased genes. by Clement F. Kent (260706)

“…<p>Three published studies decreased insulin/Tor effects via (A) ablation of <i>dilp3</i> expressing cells <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000609#pgen.1000609-Buch1" target="_blank">[28]</a>, (B) overexpression of constitutively active <i>foxo </i><a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000609#pgen.1000609-Gershman1" target="_blank">[29]</a>, or (C) rapamycin <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000609#pgen.1000609-Guertin1" target="_blank">[30]</a>. …”

The expression profiles of the selected IFNα-stimulated genes are negatively influenced by the intracellular factor IRF2. by Katharina Robichon (8445099)

“…(<b>D</b>) Upregulation of gene expression by decreased <i>IRF2</i> expression. Huh7.5 cells were incubated with 50 nM siRNA directed against <i>IRF2</i> (orange) or non-targeting control (blue) for 24 hours, and then treated with 500 U/ml IFNα. …”

Effect of on Bepridil on APP processing. by Kamran Honarnejad (485648)

“…Sulindac sulfide (50 µM) was used as a γ-secretase modulator control. …”

Human heart mtDNA topology changes in early childhood and in mitochondrial disorders involving mutations in Twinkle and PolG. by Jaakko L. O. Pohjoismäki (249430)

“…<p>The basis of the assignment of the different molecular forms is presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010426#pone.0010426-Pohjoismki1" target="_blank">[5]</a>. …”

Table_2_Antimony resistance mechanism in genetically different clinical isolates of Indian Kala-azar patients.docx by Supriya Khanra (5245634)

“…<p>The central theme of this enterprise is to find common features, if any, displayed by genetically different antimony (Sb)-resistant viscerotropic Leishmania parasites to impart Sb resistance. In a limited number of clinical isolates (n = 3), we studied the breadth of variation in the following dimensions: (a) intracellular thiol content, (b) cell surface expression of glycan having N-acetyl-D-galactosaminyl residue as the terminal sugar, and (c) gene expression of thiol-synthesizing enzymes (CBS, MST, gamma-GCS, ODC, and TR), antimony-reducing enzymes (TDR and ACR2), and antimonial transporter genes (AQP1, MRPA, and PRP1). …”

Identification of Glycoprotein Markers for Pancreatic Cancer CD24⁺CD44⁺ Stem-like Cells Using Nano-LC–MS/MS and Tissue Microarray by Jianhui Zhu (678784)

“…Herein, the malignant phenotype of pancreatic cancer stem-like CD24⁺CD44⁺ cells was isolated from a human pancreatic carcinoma cell line (PANC-1) and demonstrated 4-fold increased invasion ability compared to CD24^–CD44⁺ cells. …”

Table_1_Antimony resistance mechanism in genetically different clinical isolates of Indian Kala-azar patients.xlsx by Supriya Khanra (5245634)

“…<p>The central theme of this enterprise is to find common features, if any, displayed by genetically different antimony (Sb)-resistant viscerotropic Leishmania parasites to impart Sb resistance. In a limited number of clinical isolates (n = 3), we studied the breadth of variation in the following dimensions: (a) intracellular thiol content, (b) cell surface expression of glycan having N-acetyl-D-galactosaminyl residue as the terminal sugar, and (c) gene expression of thiol-synthesizing enzymes (CBS, MST, gamma-GCS, ODC, and TR), antimony-reducing enzymes (TDR and ACR2), and antimonial transporter genes (AQP1, MRPA, and PRP1). …”

Structure–Activity Relationship of 3‑Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors by Mirko Scortichini (4007366)

“…We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 <b>16</b>; <i>K</i>_i = 0.673 nM) and 4-iodo (MRS4620 <b>18</b>; <i>K</i>_i = 0.436 nM) substitution of the <i>N</i>⁴-benzyloxy group decreased <i>K</i>_i by ∼20-fold. Primary alkylamine derivatives coupled through a <i>p</i>-amido group with a varying methylene chain length (<b>24</b> and <b>25</b>) were functionalized congeners, for subsequent conjugation to carrier or reporter moieties. …”

Identification of Glycoprotein Markers for Pancreatic Cancer CD24⁺CD44⁺ Stem-like Cells Using Nano-LC–MS/MS and Tissue Microarray by Jianhui Zhu (678784)

“…Herein, the malignant phenotype of pancreatic cancer stem-like CD24⁺CD44⁺ cells was isolated from a human pancreatic carcinoma cell line (PANC-1) and demonstrated 4-fold increased invasion ability compared to CD24^–CD44⁺ cells. …”

Presentation_2_Antimony resistance mechanism in genetically different clinical isolates of Indian Kala-azar patients.pptx by Supriya Khanra (5245634)

“…<p>The central theme of this enterprise is to find common features, if any, displayed by genetically different antimony (Sb)-resistant viscerotropic Leishmania parasites to impart Sb resistance. In a limited number of clinical isolates (n = 3), we studied the breadth of variation in the following dimensions: (a) intracellular thiol content, (b) cell surface expression of glycan having N-acetyl-D-galactosaminyl residue as the terminal sugar, and (c) gene expression of thiol-synthesizing enzymes (CBS, MST, gamma-GCS, ODC, and TR), antimony-reducing enzymes (TDR and ACR2), and antimonial transporter genes (AQP1, MRPA, and PRP1). …”

GD3 Synthase Overexpression Sensitizes Hepatocarcinoma Cells to Hypoxia and Reduces Tumor Growth by Suppressing the cSrc/NF-κB Survival Pathway by Josep M. Lluis (256726)

“…<div><h3>Background</h3><p>Hypoxia-mediated HIF-1α stabilization and NF-κB activation play a key role in carcinogenesis by fostering cancer cell survival, angiogenesis and tumor invasion. …”

Presentation_3_Antimony resistance mechanism in genetically different clinical isolates of Indian Kala-azar patients.pptx by Supriya Khanra (5245634)

“…<p>The central theme of this enterprise is to find common features, if any, displayed by genetically different antimony (Sb)-resistant viscerotropic Leishmania parasites to impart Sb resistance. In a limited number of clinical isolates (n = 3), we studied the breadth of variation in the following dimensions: (a) intracellular thiol content, (b) cell surface expression of glycan having N-acetyl-D-galactosaminyl residue as the terminal sugar, and (c) gene expression of thiol-synthesizing enzymes (CBS, MST, gamma-GCS, ODC, and TR), antimony-reducing enzymes (TDR and ACR2), and antimonial transporter genes (AQP1, MRPA, and PRP1). …”

Presentation_1_Antimony resistance mechanism in genetically different clinical isolates of Indian Kala-azar patients.pptx by Supriya Khanra (5245634)

“…<p>The central theme of this enterprise is to find common features, if any, displayed by genetically different antimony (Sb)-resistant viscerotropic Leishmania parasites to impart Sb resistance. In a limited number of clinical isolates (n = 3), we studied the breadth of variation in the following dimensions: (a) intracellular thiol content, (b) cell surface expression of glycan having N-acetyl-D-galactosaminyl residue as the terminal sugar, and (c) gene expression of thiol-synthesizing enzymes (CBS, MST, gamma-GCS, ODC, and TR), antimony-reducing enzymes (TDR and ACR2), and antimonial transporter genes (AQP1, MRPA, and PRP1). …”

Structure–Activity Relationship of 3‑Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors by Mirko Scortichini (4007366)

“…We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 <b>16</b>; <i>K</i>_i = 0.673 nM) and 4-iodo (MRS4620 <b>18</b>; <i>K</i>_i = 0.436 nM) substitution of the <i>N</i>⁴-benzyloxy group decreased <i>K</i>_i by ∼20-fold. Primary alkylamine derivatives coupled through a <i>p</i>-amido group with a varying methylene chain length (<b>24</b> and <b>25</b>) were functionalized congeners, for subsequent conjugation to carrier or reporter moieties. …”

Competitive bio-panning assay shows specific binding of T7-ATERF-1 clone to the three strains of <i>Pseudomonas</i>. by Cristina Rioja (277145)

“…<p>(<b>A</b>) Competition between T7-ATERF-1 phage (which expresses ATERF-1 polypeptide) and T7-C1 (competing phage randomly selected). …”

Structure–Activity Relationship of 3‑Methylcytidine-5′-α,β-methylenediphosphates as CD73 Inhibitors by Mirko Scortichini (4007366)

“…We now expand the structure–activity relationship of pyrimidine nucleotides as human CD73 inhibitors. 4-Chloro (MRS4598 <b>16</b>; <i>K</i>_i = 0.673 nM) and 4-iodo (MRS4620 <b>18</b>; <i>K</i>_i = 0.436 nM) substitution of the <i>N</i>⁴-benzyloxy group decreased <i>K</i>_i by ∼20-fold. Primary alkylamine derivatives coupled through a <i>p</i>-amido group with a varying methylene chain length (<b>24</b> and <b>25</b>) were functionalized congeners, for subsequent conjugation to carrier or reporter moieties. …”

Data Sheet 1_Antiviral therapy can effectively suppress irAEs in HBV positive hepatocellular carcinoma treated with ICIs: validation based on multi machine learning.zip by Shuxian Pan (8868356)

“…However, Immunotherapy-related adverse reactions are still a major challenge faced by tumor immunotherapy, so it is urgent to establish new methods to effectively predict immunotherapy-related adverse reactions.…”

Text S1 - Down-Regulating Sphingolipid Synthesis Increases Yeast Lifespan by Xinhe Huang (185390)

“…Figure S2: Myriocin treatment decreases cell size. DBY746 cells were grown with and without myriocin (Myr) as in a CLS assay using SDC medium (pH 4.5, 3X iron). …”

Image_4_Retrospective investigation of the origin and epidemiology of the dengue outbreak in Yunnan, China from 2017 to 2018.TIF by Liang Cao (135383)

Image_1_Retrospective investigation of the origin and epidemiology of the dengue outbreak in Yunnan, China from 2017 to 2018.TIF by Liang Cao (135383)