An Integrated Disease/Pharmacokinetic/Pharmacodynamic Model Suggests Improved Interleukin-21 Regimens Validated Prospectively for Mouse Solid Cancers by Moran Elishmereni (203218)

“…Simulations of the verified model surfaced important therapeutic insights: (1) Fractionating the standard daily regimen (50 µg/dose) into a twice daily schedule (25 µg/dose) is advantageous, yielding a significantly lower tumor mass (45% decrease); (2) A low-dose (12 µg/day) regimen exerts a response similar to that obtained under the 50 µg/day treatment, suggestive of an equally efficacious dose with potentially reduced toxicity. …”

<b>Genome assembly at chromosome level and evolutionary analysis of </b><i><b>Coregonus ussurinsis</b></i><b> Berg</b> by Tianqing Huang (9743483)

“…The sequence length was 2,627.19 Mb with a contig N50 length of 4.27 Mb. Then 3,109 contigs were assembled into scaffolds, resulting in a genome assembly with 40 chromosomes and a scaffold N50 length of 62.20 Mb, and the size of the genome was 2.51 Gb, and the integrity was more than 95% by BUSCO test. …”

Energy landscapes of the model with and without descending loops. by Pantelis Leptourgos (9767840)

“…Descending loops generate a bistable attractor, whose stable fixed points correspond to (strong beliefs about) the two interpretations (blue). …”

Data_Sheet_1_Microbial Interactions With Dissolved Organic Matter Drive Carbon Dynamics and Community Succession.docx by Xiaoqin Wu (470428)

“…In this study, we fed sediment-derived dissolved organic matter (DOM) to groundwater microbes and continually analyzed microbial transformation of DOM over a 50-day incubation. …”

Nutritional and Protein Deficiencies in the Short Term following Both Gastric Bypass and Gastric Banding by Judith Aron-Wisnewsky (544060)

“…Serum analysis demonstrated a continuous decrease in prealbumin during the follow-up, indicating mild protein depletion in 21 and 57% of GBP patients and 50 and 63% of AGB patients, respectively, at T1 and T3. …”

Image1_Sleep and Alcohol Use Patterns During Federal Holidays and Daylight Saving Time Transitions in the United States.JPEG by Rachel M. Heacock (13025589)

“…For example, New Year’s Eve corresponded with a sleep consistency decrease of 13.8 ± 0.3%, a sleep onset delay of 88.9 ± 3.2 min (00:01 vs. 22:33 baseline) later, a sleep offset delay of 78.1 ± 3.1 min (07:56 vs. 06:39), and an increase in the prevalence of alcohol consumption, with more than twice as many participants having reported alcohol consumption [+138.0% ± 6.7 (74.2% vs. 31.2%)] compared to baseline. …”

DataSheet_1_Noninvasive Analysis of Tree Stems by Electrical Resistivity Tomography: Unraveling the Effects of Temperature, Water Status, and Electrode Installation.pdf by Andrea Ganthaler (7860380)

“…Removal of the periderm resulted in a slight decrease of high ER peaks. Installation of electrodes for a short period of 32–72 h before conducting the tomography caused small distortions in tomograms. …”

Effects of land use and microclimate changes on ant foraging in two Neotropical biomes by Icaro Wilker (17548428)

“…We sampled between 8 a.m. and 12 p.m., however, the transect had only 5 sampling points spaced 50 m apart. …”

Dynamics and steady state profiles for the astrocyte/ECS-system. by Geir Halnes (343071)

“…<p>(A–D) Dynamics of selected variables in a point () in the input zone. …”

Image_1_Cardiac resynchronization therapy in heart failure patients by using left bundle branch pacing.TIF by Ying Gu (203149)

“…</p>Results<p>Left bundle branch pacing was successful in all 34 patients (mean age 65.6 ± 11.2 years, 67.6% men). A significant decrease in QRS duration (QRSd) was observed after the LBBP operation for 1 month (153.2 ± 1.7 vs. 111.9 ± 2.6 ms, p < 0.01). …”

<i>vang-1(tm1422)</i> life span modulation depends on Insulin/IGF-1-like signaling and leads to higher DAF-16 activity. by Sebastian J. Honnen (183696)

“…In contrast, depletion of DAF-16 by RNAi in <i>tm1422</i> (rose spotted line) and WT (purple solid line) causes a decrease of mean life span to <b>12±0.3 d</b> (n = 247*) and <b>11.9±0.2 d</b> (n = 142*), respectively (p<0.96**). …”

Supplementary Material for: Sclerostin Declines during Hemodialysis and Appears in Dialysate by Bielesz B.O. (4147096)

“…In a subset of patients (n = 19) sclerostin was measured in serum at start, 1, 2, and 3 h of dialysis and in the effluent dialysate at several points in time. …”

Data_Sheet_1_Seagrass Colonization Alters Diversity, Abundance, Taxonomic, and Functional Community Structure of Benthic Microbial Eukaryotes.docx by Ying Pan (90050)

Image_2_The DOF-Domain Transcription Factor ZmDOF36 Positively Regulates Starch Synthesis in Transgenic Maize.JPEG by Jiandong Wu (737216)

Supplementary Material for: Population-Attributable Risk Fractions for Antiplatelets and Anticoagulants in Spontaneous Intracranial Hemorrhages by Choi H.H. (14759125)

DCAF13 promotes triple-negative breast cancer metastasis by mediating DTX3 mRNA degradation by Jiazhe Liu (9754115)

Image_1_The DOF-Domain Transcription Factor ZmDOF36 Positively Regulates Starch Synthesis in Transgenic Maize.JPEG by Jiandong Wu (737216)

Accelerometric outcomes of motor function related to clinical evaluations and muscle involvement in dystrophic dogs by Mutsuki Kuraoka (6069350)

DUX4 Binding to Retroelements Creates Promoters That Are Active in FSHD Muscle and Testis by Janet M. Young (79201)

Accelerated Immunodeficiency by Anti-CCR5 Treatment in HIV Infection by Ariel D. Weinberger (169848)

“…The model shows that the R5-to-X4 switch occurs as CD4⁺ T cell activation levels increase above a threshold and as CD4⁺ T cell counts decrease below a threshold during late-stage HIV infection. …”