Following OGD mTOR phosphorylation is reversed by rapamycin treatment. by Lauren Fletcher (353321)

“…<p>Primary cortical neurons were subjected to 1 h OGD and then treated with rapamycin (20 nM) or vehicle (0.01% EtOH) for multiple time points (1.5 h–24 h). (A,B) Following OGD, rapamycin significantly decreased the phosphorylation of mTOR at both Ser-2448 and Ser-2481 compared to vehicle for all time points. …”

Neurons in the hippocampal CA1 region 14 days after resuscitation. by Xin Liu (43569)

“…White arrow indicates the heterochromatin clusters in the nucleus, black arrows indicate mitochondria with disordered, fractured, and dissolved cristae, and blue arrow indicates a decrease in attached ribosomes.Scale bar in <b>(A)</b>,(C)=2µm. …”

Metabolic heat-maps based on quantitative NMR spectroscopic data sets in HT29 and HCT116 xenografts at the end of the study. by Erica L. Bradshaw-Pierce (387172)

“…Metabolic pathways which were undisturbed by treatment are presented as yellow maps. A decrease in metabolic end-point is indicated by red, while an increase by green spots. …”

ACE reduces body weight whereas ICE increases body fat accumulation. by Hyung sun Yoo (558931)

“…Data presented are mean ±SEM, n = 5–6, *p<0.05 Control vs. ICE mice at a given time point; #<0.05 vs. day 1 baseline.</p>…”

Circulating Mesenchymal Stem Cells Microparticles in Patients with Cerebrovascular Disease by Suk Jae Kim (135028)

“…The expression of CD105 (a surface marker of MSCs) and CXCR4 (a CXC chemokine receptor for MSC homing) on circulating microparticles was evaluated by flow cytometry of samples from 111 patients and 50 healthy subjects. …”

Data_Sheet_1_Spatial Resolution of Suprachoroidal–Transretinal Stimulation Estimated by Recording Single-Unit Activity From the Cat Lateral Geniculate Nucleus.docx by Tomomitsu Miyoshi (540393)

“…As the stimulation became weaker, this distance decreased to 1.8° at 150 and 100 μA. As another estimation, the radius of 25% response probability was 1.4° at 100 μA. …”

Data_Sheet_1_Spatial Resolution of Suprachoroidal–Transretinal Stimulation Estimated by Recording Single-Unit Activity From the Cat Lateral Geniculate Nucleus.pdf by Tomomitsu Miyoshi (540393)

“…As the stimulation became weaker, this distance decreased to 1.8° at 150 and 100 μA. As another estimation, the radius of 25% response probability was 1.4° at 100 μA. …”

Disruption of EAE pathogenesis by B cell depletion. by Nancy L. Monson (121113)

“…EAE onset and severity were monitored using a 5-point scale on WTLM and hCD20Tg mice immunized with MOG_1–125. …”

Use of GPCR-HIT to show effect of AT₁ receptor activation on CCR2/Gα_i1 proximity. by Mohammed Akli Ayoub (176430)

“…It has been observed previously [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119803#pone.0119803.ref039" target="_blank">39</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119803#pone.0119803.ref041" target="_blank">41</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119803#pone.0119803.ref042" target="_blank">42</a>,<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119803#pone.0119803.ref044" target="_blank">44</a>] that the BRET signal can increase or decrease as a consequence of the ligand-induced conformational change associated with Gα_i1 protein activation (A). …”

Fitness and distribution of gamete types. by Joshua R. Christie (725052)

“…This more than offsets the decrease in the proportion of heteroplasmic cells and <math><mrow><msub><mrow><mi>w</mi><mo stretchy="true">¯</mo></mrow><mrow><msub><mi>B</mi><mn>1</mn></msub></mrow></msub></mrow></math> continues to decrease <b>(A)</b>. …”

Hormone addition results in chromatin changes at individual GR-regulated genes. by Chuong D. Pham (111374)

“…We calculate that a nucleosome/bare ratio of 1.0 corresponds to ∼50% nucleosome occupancy, while a value of 2.1 corresponds to 100% occupancy (e.g. a nucleosome covering a given location on all gene copies). …”

Changes in human intervertebral disc biochemical composition and bony end plates between middle and old age by Delio Eulalio Martins (5759282)

“…</p><p>Results</p><p>The old-aged group showed a decrease in content of sulphated and non-sulphated glycosaminoglycans relative to middle-aged and there were also alterations in the proportion of GAG disaccharides and a decrease of collagen fiber size. …”

Donor and Geometry Optimization: Fresh Perspectives for the Design of Polyoxometalate Charge Transfer Chromophores by Bethany R. Hood (20396768)

Table 1_Role of seed priming using natural biostimulants in reducing salt stress effects by reshaping physio-biochemical and antioxidant defense systems in glycine max seedlings.do... by Mostafa M. Rady (14004633)

“…<p>Abiotic stress significantly damages crops, reducing global yields by over 50%. Among these challenges, salt stress poses a critical constraint that severely affects the growth, productivity, and quality of soybeans in various regions worldwide. …”

Brivanib inhibits liver fibrosis induced by thioacetamide. by Ikuo Nakamura (548298)

“…(B) The number of bands of bridging fibrosis per high power field were counted in images obtained at 100× magnification after Sirius red staining. There was a significant decrease in the number of bands in both the 25 mg/kg and 50 mg/kg brivanib groups, compared to placebo. …”

Collagen XVI overexpression leads to an increase of ILK/kindlin-1 interaction. by Konstanze B. Bedal (513309)

“…<p>(<b>A</b>) Proximity ligation assay for the analysis of ILK/kindlin-1 interaction in COLXVI and mock control cells (scale bar equals 50 µm). …”

The effect of dopamine on Δψ_m and [Ca²⁺]_c in midbrain neurons and astrocytes. by Sonia Gandhi (49260)

“…Furthermore this increase in [Ca²⁺]_c is associated with a reduction in ΔΨ_m. Application of 50 mM KCl induces a further rise in [Ca²⁺]_c and profound mitochondrial depolarisation. …”

Optically Controlled Thermophoretic Trapping of Single Nano-Objects by Marco Braun (1552906)

Optically Controlled Thermophoretic Trapping of Single Nano-Objects by Marco Braun (1552906)

Optically Controlled Thermophoretic Trapping of Single Nano-Objects by Marco Braun (1552906)