Impact of Global <i>Fxr</i> Deficiency on Experimental Acute Pancreatitis and Genetic Variation in the <i>FXR - Figure 2 </i> Locus in Human Acute Pancreatitis by Rian M. Nijmeijer (208613)

“…<p>A - Representative pancreatic histology following induction of acute pancreatitis (H&E staining, 20x and 100x consecutive magnifications for each experimental group): wild-type control (a,b); wild-type acute pancreatitis (c,d); Fxr^-/- control (e,f); Fxr^-/- acute pancreatitis (g,h). …”

DHEA and DHEA8354 suppress the growth of mammary tumors by Anne Shilkaitis (15502)

“…Growth curves of mammary tumors in animals treated with dehydroepiandrosterone (DHEA) (b) or DHEA 8354 (c) (1,000 mg/kg in diet). In 50% of DHEA-treated tumors a net decrease in growth potential over control was observed, whereas with DHEA 8354 some animals showed a decrease in growth potential. …”

Effects of FAK inhibitor Y15 and RGD peptide on cumulus expansion <i>in vitro</i>. by Hiroya Kitasaka (4840218)

“…COCs were isolated from ovaries of mice primed with eCG for 48 h. Non-expanded COCs were selected, and 50 COCs were cultured in a 50 μl drop of defined medium containing 1% FBS and 100 ng/ml AREG. …”

Description of the Obesity Prevention and Treatment Intervention Alternatives. by Leah M. Frerichs (498682)

“…<p>All interventions were modeled with a 50% continuous linear increase or decrease in designated parameters over the course of 10 years</p>…”

PA28αβ silencing increases mHTT aggregation in ST<i>Hdh</i> cells. by Karlijne W. Geijtenbeek (14304969)

“…<p>(A) ST<i>Hdh</i> cells treated with shPA28α show decreased PA28α protein levels. Data are normalized to shC002 treated cells and shown as mean ± SEM (n = 6). …”

Binding of <i>Sp</i> CBPs to insoluble polymeric substrates. by Pallinti Purushotham (166740)

“…(A and C) <i>Sp</i> CBP21, (B and D) <i>Sp</i> CBP50. …”

Presentation_1_Influence of acetate- vs. lactate-containing fluid bolus therapy on acid-base status, electrolytes, and plasma lactate in dogs.PPTX by Ute Klein-Richers (13172571)

Analysis of the inner ear cell type–specific transcriptome. by Ronna Hertzano (203344)

Swimming endurance training protocol. by Vítor S. Fernandes (21262991)

“…This study aimed to investigate the effect of <i>MIB1</i> mutations on cardiac electrical activity. We examined male <i>Mib1</i>^<i>flox</i><i>;Tnnt2</i>^<i>Cre</i> mice, a disease model of LVNC, and wildtype littermates on the C57BL/6J genetic background. …”

N-cadherin localization changes during and after KCl depolarization. by Patricia T. Yam (478888)

“…<p>(<b>A</b>,<b>B</b>) During depolarization with 30-50 mM KCl, the proportion of synapses with N-cadherin puncta adjacent to the active zone increases, whereas the proportion of synapses with N-cadherin along the synaptic cleft decreases. n=3 experiments, ≥88 synapses per experiment, total of 315 synapses (178 and 137 synapses for the control and during KCl stimulation conditions respectively). * = p<0.05, ** = p<0.01, two-way ANOVA with matched values and Bonferroni post-test. …”

The impact of sample size reduction timing on the precision of the estimate of the differential effect of treatment. by Ognjen Arandjelović (295373)

New Targets for Drug Discovery against Malaria by Guido Santos (171018)

Effects of <i>tel1Δ rad3Δ</i> mutations on recruitment of telomere capping complexes. by Bettina A. Moser (260302)

“…Compared to untagged control, Poz1 showed significant telomere binding in wt, <i>tel1Δ</i>, <i>rad3Δ</i>, and <i>tel1Δ rad3Δ</i> (P values <0.0001), but no significant changes among wt and different mutant strains were found (P values ranged from 0.144 to 0.887). For Stn1 (E), mean values plus or minus one standard deviation from three to four independent experiments are plotted. …”

DataSheet1_PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo.docx by Alexia Chauzy (12247643)

<i>P</i>. <i>aeruginosa</i> secreted virulence factors induce ER stress in primary bronchial epithelial cells. by Emily F. A. van ‘t Wout (756193)

“…Time-dependent induction of ER stress in primary bronchial epithelial cells, as assessed by <i>XBP1</i> splicing, <i>CHOP</i> and <i>GADD34</i> mRNA after treatment with CM-PAO1 (n = 5; mean ± SEM). B. Dose-response of spliced <i>XBP1</i>, <i>CHOP</i> and <i>GADD34</i> mRNA in primary bronchial epithelial cells treated with CM-PAO1 for 12 hours (n = 5; mean ± SEM). …”

Overexpression of miR-130a inhibits translation of mRNA containing the 3′UTR of FOG-2. by Gene H. Kim (371958)

“…Results reported are the mean±S.E.M. (n = 12); ‘*’ indicates statistically significant decrease in activity (p<0.001).…”

Effects of TTP2515 on metabolic and calorimetry parameters in leptin-deficient mice. by Roxanne Dutia (418714)

“…(<b>C</b>) Body weight was significantly lower in TTP2515-treated mice on the 50 mg/kg dose. (<b>D</b>) Immediately upon starting the 50 mg/kg dose, mean respiratory quotient was significantly decreased in TTP2515 treated mice during the light cycle. …”

Influence of COS on the activation of NF-κB in retina and RGC-5 cells. by I-Mo Fang (470460)

“…(B) COS decreased the amount of activated NF-κB translocated into nucleus in PQ-stimulated RGC-5 in a time-dependent and (C) dose-dependent manner. …”

Roles of Cochaperones HOP and CHIP in KCNQ4 Biosynthesis. by Yanhong Gao (244711)

“…Over-expression of cochaperone HOP led to a significant increase, whereas over-expression of CHIP resulted in a marked decrease in total KCNQ4 level. <i>E. & F. Effects of siRNA knockdown of HOP or CHIP on total KCNQ4 level</i> HEK293T cells were transfected with 0.4 µg of pCMV6-XL5-HA-KCNQ4 (+) and various amount of siRNA as indicated. …”

Time course development of insulin resistance, adipose and liver inflammation. by Petra Mulder (462809)

“…(B) HFD feeding resulted in a gradual decrease of tissue-specific uptake of glucose into white adipose tissue (WAT). …”