Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease حسب Yi Sun (118759)

"…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …"

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease حسب Yi Sun (118759)

"…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …"

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease حسب Yi Sun (118759)

"…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …"

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease حسب Yi Sun (118759)

"…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …"

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease حسب Yi Sun (118759)

"…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …"

Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease حسب Yi Sun (118759)

"…<b>SZM679</b>, a highly specific RIPK1 inhibitor (<i>K</i>_d,RIPK1 = 8.6 nM, <i>K</i>_d,RIPK3 > 5000 nM), was developed by our group with superior high antinecroptotic activity (EC₅₀ = 2 nM), and investigated to completely reverse the tumor necrosis factor-induced systemic inflammatory response syndrome. …"

Discovery of IHMT-MST1-58 as a Novel, Potent, and Selective MST1 Inhibitor for the Treatment of Type 1/2 Diabetes حسب Yun Wu (150224)

الموضوعات:

Discovery of IHMT-MST1-58 as a Novel, Potent, and Selective MST1 Inhibitor for the Treatment of Type 1/2 Diabetes حسب Yun Wu (150224)

الموضوعات:

Titanate Nanosheets/Cellulose Composite Showing Improved Crystallinity and Decreased Water Wettability by Gamma-Irradiation حسب Yaowaluk Tariwong (22630109)

Mitochondrial protein acetylation correlates with a decrease in sirtuin 3 levels. حسب Mercedes García-Roche (6459200)

Bacterial co-abundance networks decreases in complexity with lower host genetic variation. حسب Michael Ørsted (5926028)

C4BP is necessary and sufficient for serum-mediated decrease in neutrophil internalization of OpaD+ Gc. حسب Lacie M. Werner (14710419)

Quantifications of SEMG1-2 combined with measurements of CpG methylation levels in the Svs2 and Svs3ab promoters. حسب Ludwig Stenz (779897)

"…(D) Western blot quantifications revealing decreased SEMG2 in sperm of C57.D300.F1 (p<0.04) and C57.D300.F3 (p<0.004) compared with C57.CTL.F1. …"

Tax expression is associated with decreased cellular motility. حسب Saumya Ramanayake (7879091)

An increase in MOI decreases neuronal dendrite numbers. حسب Emily Z. Tabaie (16630841)

Stability scores with refinement, no USM decreases, no W. حسب Jedediah M. Singer (10331212)

"…<p>Effects of guided and random substitutions within GM designs with a maximum sequence identity to any expert-designed protein of less than 50%, when guided substitutions are not permitted to decrease USM EC₅₀ predictions and neither guided nor random substitutions are allowed to change amino acids to tryptophan.…"

Stability scores with refinement, no USM decreases, no AFILMVWY. حسب Jedediah M. Singer (10331212)

"…<p>Effects of guided and random substitutions within GM designs with a maximum sequence identity to any expert-designed protein of less than 50%, when guided substitutions are not permitted to decrease USM EC₅₀ predictions and neither guided nor random substitutions are allowed to change amino acids to alanine, phenylalanine, isoleucine, leucine, methionine, valine, tryptophan, or tyrosine.…"

Cigarette smoke decreases clathrin mediated endocytosis. حسب Parker F. Duffney (8878145)

VHFD becomes dehydrated, decreasing its palatability. حسب Joshua Cordeira (17002146)

"…(B) Mass lost correlated with VHFD preference. (C) Dehydrating VHFD decreased preference to consume it. …"

HFD decreases nephrocyte uptake of dextran and albumin. حسب Aleksandra Lubojemska (10746241)