Zebrafish harboring homozygous mutations in <i>gdf6</i> exhibit decreased endurance. by Michèle G. DuVal (278183)

“…<b>C.</b> Open field tests of average swim velocity during 10 minutes of each hour through a circadian cycle, in tanks replicating lifetime husbandry conditions, show a lower mean movement at night (in either genotype, **p<0.01) but no difference between genotypes in any measure during day (p = 0.247) or night (p = 0.814).…”

ΔAMP null mutants exhibit decreased climbing and increased sleep after TBI. by Bart van Alphen (12003724)

“…<p>(<b>A)</b> ΔAMP null mutants show decreased climbing 24 hours after TBI, similar to controls (<i>n</i> = 50–66) <b>(B)</b> Sleep is decreased in controls 24 hour after TBI <b>(C)</b> but is increased in ΔAMP null mutants (<i>n</i> = 56–95). *** <i>p</i> < 0.001, * <i>p</i> < 0.05 by <i>t</i> tests with Bonferroni correction. …”

Curcumin induces phosphorylation of p38 MAPK and decreases phosphorylation of Akt in RPE cells. by Margrit Hollborn (394459)

“…Curcumin was tested at 50 and 100 µM. <b>C.</b> Dose-dependence of the curcumin effect on the phosphorylation level of Akt. …”

Inducible and conditional knockout (icKO) of ERK5 decreases adult OB neurogenesis. by Tan Li (404990)

The number of prospermatogonia is decreased in <i>Chtf18</i>^−/− neonatal testes. by Karen M. Berkowitz (123502)

Ethanol decreases hepatic ATP and causes modest liver injury: protection by Alda-1. by Zhi Zhong (314411)

Complex I activity is increased in cells with elevated NQO1 levels and is decreased by rotenone. by Jiyeong Kim (433042)

Rapamycin decreases Schwann cell markers, whereas statin induces Schwann cell markers. by Andrea Preitschopf (629851)

GBE did not modify cell morphology but decreased reactive oxygen species (ROS) levels. by Virginie Rhein (243241)

“…<p>Morphological analysis of vector control and APP cells showed neuroblast-like morphology with differentiated perikaria (<i>arrows</i>) and occasional short neurites (<i>arrowheads</i>). <b>A</b>) Transfection of SH-SY5Y cells with cDNAs (pCEP4 vector) containing the vector alone or the entire coding region of wild-type human APP (APP cells) and <b>B</b>) GBE treatment (100 µg/ml; 24 h) did not significantly change general cell morphology. …”

Simvastatin decreases cerebral vasospasm of the middle cerebral artery and reduces microthromboemboli after SAH. by Mohammed Sabri (355717)

“…<p><b>A.</b> Representative images showing vasospastic MCA in vehicle treated mice, as compared to larger diameter MCAs from the two simvastatin treated groups that are similar to MCA in naïve group. …”

hESCs-Exo decreased cancer cell proliferation and increased cancer cell death. by Shufeng Zhou (398572)

Behavioral response to ambiguous conditioned fear cues is decreased in adult neurogenesis-deficient mice. by Lucas R. Glover (3912628)

Gfap typically increases with disease progression but decreases in some models in advanced stages of degeneration. by Claire Hippert (171005)

“…<i>Pde6b</i>^{<i>rd1/rd1</i>} animals showed a bimodal pattern of Gfap synthesis, with staining being particularly strong at the mid stage, but decreasing thereafter (i-vi). …”

Treatment with TDF decreased cell viability and induced morphological changes in hepatic stellate cells. by Sung Won Lee (222509)

RIG-I deficient mice demonstrate decreased protection against heterologous IAV challenge. by Matheswaran Kandasamy (105167)

Hsp90 inhibition decreases the adipogenic transcriptional program without any effect on cytotoxicity. by Sébastien Desarzens (547289)

Expression of neurotrophins and their receptors was decreased in <i>Slitrk6</i>-deficient inner ear. by Kei-ichi Katayama (257931)

“…Furthermore, phosphorylated form of Ntrk (p-Ntrk) protein was decreased in the knockout mice. Amounts of a neuronal marker (βIII tubulin) and a sensory epithelium marker (Myosin VIIa) were comparable between the wild-type and knockout mice. …”

Increased osteoblastic activity and decreased osteoclastogenesis in TgLRAP cells <i>in vitro</i>. by Naoto Haruyama (487384)

“…Compared with the co-culture of WT BMCs and WT calvarial cells (WT / WT), the number of osteoclasts were significantly decreased at 50% in the co-cultures of TgLRAP BMCs and TgLRAP calvarial cells (TgLRAP / TgLRAP) (graph). …”

mPEG PV1-Fab’ treatment decreases T_reg population. by Pedro Henrique Papotto (791904)

Exposure to low CO₂ levels decreases ER cholesterol levels. by Nityanand Bolshette (17396845)

“…<b>(D, E)</b> The free cholesterol and cholesterol ester levels in the ER membrane from the cells as in <b>(C)</b>, were quantified with shotgun lipidomics analysis (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s007" target="_blank">S7 Fig</a> and <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002367#pbio.3002367.s012" target="_blank">S5 Table</a>) (mean ± SE, <i>n</i> = 3 independent experiments, **<i>P</i> < 0.01, *<i>P</i> < 0.05, nonsignificant (ns) two-sided Student’s <i>t</i> test). …”