datasheet1_The Expiry of Humira® Market Exclusivity and the Entry of Adalimumab Biosimilars in Europe: An Overview of Pricing and National Policy Measures.pdf by Evelien Moorkens (4723848)

“…When reported, discounts/rebates on originator adalimumab after loss of exclusivity ranged from 0% to approximately 26% (Romania), 60% (Poland), 80% (Denmark, Italy, Norway), and 80–90% (Netherlands), leading to actual prices per pen or syringe between €412 (Finland) and €50 – €99 (Netherlands). To leverage competition following entry of biosimilar adalimumab, only a few countries adopted measures specifically for adalimumab in addition to general policies regarding biosimilars. …”

Toll-Like Receptor-2 Mediates Diet and/or Pathogen Associated Atherosclerosis: Proteomic Findings by Monika Madan (95727)

“…</p><h3>Methods and Results</h3><p>To explore the role of TLR2 in inflammation- and infection-associated atherosclerosis, 10 week-old ApoE^+/−-TLR2^+/+, ApoE^+/−-TLR2^+/− and ApoE^+/−-TLR2^−/− mice were fed either a high fat diet or a regular chow diet. All mice were inoculated intravenously, once per week for 24 consecutive weeks, with 50 µl live <em>Porphyromonas gingivalis</em> (<em>P.g</em>) (10⁷ CFU) or vehicle (normal saline). …”

4-Octyl itaconate attenuates renal tubular injury in db/db mice by activating Nrf2 and promoting PGC-1α-mediated mitochondrial biogenesis by Muqing Shao (15238576)

“…<i>Irg1</i> knockout mice were generated. db/db mice were treated with 4-octyl itaconate (4-OI, 50 mg/kg), a derivative of itaconate, for 4 weeks. …”

Identification of whole blood mRNA and microRNA biomarkers of tissue damage and immune function resulting from amphetamine exposure or heat stroke in adult male rats by Luísa Camacho (5508251)

“…Most transcripts specific for T-cells decreased 50–70% after AMPH exposure or EIH, with the noted exception of <i>Ccr5</i> and <i>Chst12</i>. …”

Mobility Competitiveness and Security: Expatriate Perspectives from Qatar by Ewers, Michael Christopher

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DataSheet1_Mechanism of Tripterygium wilfordii Hook.F.- Trichosanthes kirilowii Maxim decoction in treatment of diabetic kidney disease based on network pharmacology and molecular... by Lingfei Lu (5400374)

“…Molecular docking results showed that kaempferol, triptolide, nobiletin, and schottenol had a strong binding ability to PTGS2 and RELA. Furthermore, the in vitro experiments confirmed that LTD effectively decreased the expression of PTGS2, NF-κB, JNK, and AKT in the HG-induced DKD model.…”

Image_1_Measurement of Ocular Compliance Using iPerfusion.pdf by Joseph M. Sherwood (7543700)

“…<p>The pressure-volume relationship of the eye is determined by the biomechanical properties of the corneoscleral shell and is classically characterised by Friedenwald's coefficient of ocular rigidity or, alternatively, by the ocular compliance (OC), defined as dV/dP. OC is important in any situation where the volume (V) or pressure (P) of the eye is perturbed, as occurs during several physiological and pathological processes. …”

Data_Sheet_1_Measurement of Ocular Compliance Using iPerfusion.pdf by Joseph M. Sherwood (7543700)

“…<p>The pressure-volume relationship of the eye is determined by the biomechanical properties of the corneoscleral shell and is classically characterised by Friedenwald's coefficient of ocular rigidity or, alternatively, by the ocular compliance (OC), defined as dV/dP. OC is important in any situation where the volume (V) or pressure (P) of the eye is perturbed, as occurs during several physiological and pathological processes. …”

Table 1_Multicenter epidemiology of Stenotrophomonas maltophilia bloodstream infections in Indian ICUs: building digital surveillance network.pdf by Parul Singh (191877)

“…Mortality was highest in secondary BSIs (60%), followed by CLABSIs (50.3%) and non-CLABSIs (36.4%). The median ICU stay for CLABSI patients was 21 days. …”

Table1_Prognostic value of LECT2 and relevance to immune infiltration in hepatocellular carcinoma.DOCX by Jiangfeng Qin (5618006)

“…However, there are still no studies with a comprehensive analysis of the role of LECT2 in hepatocellular carcinoma (HCC).…”

Maximal expiratory pressure is associated with reinstitution of mechanical ventilation after successful unassisted breathing trials in tracheostomized patients with prolonged mecha... by Shwu-Jen Lin (8555895)

“…Multivariable Cox regression analysis showed fever at RCC discharge (hazard ratio [HR] 14.00, 95% confidence interval [CI] 3.2–61.9) chronic obstructive pulmonary disease (HR 2.37, 95% CI 1.34–4.18), renal replacement therapy at the ICU (HR 2.29, 95% CI 1.50–3.49) and extubation failure before tracheostomy (HR 1.76, 95% CI 1.18–2.63) were associated with increased risks of reinstitution, while P_Emax > 30 cmH₂O (HR 0.51, 95% CI 0.35–0.76) was associated with a decreased risk of reinstitution.…”

Data_Sheet_2_Effects of yeast culture on growth performance, immune function, antioxidant capacity and hormonal profile in Mongolian ram lambs.pdf by Hui Chen (28597)

“…The dietary treatments were: total mixed ration (TMR) as the control group, TMR supplemented with 50–70 g/kg yeast culture (YC) or 75 mg/kg β-glucan. …”

PINK1 auto-phosphorylation is impaired by L347P and E417G mutations. by Wencheng Liu (374270)

“…Spot 1, 2 (64 kD), and 3 (50 kD) migrated to the acidic end, and several others (open arrows) to the basic end. 2^nd panel: A control of wild type PINK1 proteins treated with alkaline phosphotase (AP). …”

Table_1_Effects of yeast culture on growth performance, immune function, antioxidant capacity and hormonal profile in Mongolian ram lambs.docx by Hui Chen (28597)

“…The dietary treatments were: total mixed ration (TMR) as the control group, TMR supplemented with 50–70 g/kg yeast culture (YC) or 75 mg/kg β-glucan. …”

Anti-proliferative and Anti-metastatic Effect of Aqueous Extract of Origanum Syriacum on Aggressive Human Breast Cancer Cells by Alkahlout, Amal Shahada

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Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn... by Esther M. Speer (5158913)

“…<div><p>Introduction</p><p>Neonatal inflammation, mediated in part through Toll-like receptor (TLR) and inflammasome signaling, contributes to adverse outcomes including organ injury. Pentoxifylline (PTX), a phosphodiesterase inhibitor which potently suppresses cytokine production in newborn cord blood, is a candidate neonatal anti-inflammatory agent. …”

Genetic dissection of the relationships between grain yield components by genome-wide association mapping in a collection of tetraploid wheats by Giacomo Mangini (427579)

“…Out of eight KNS QTL, three were associated to significant increases of GYS, while the increased grain number of five additional QTL was completely or partially compensated by decreases in grain weight, thus producing no or reduced effects on GYS. …”

PQ-treatment causes energy stress <i>in vivo</i> and activates energy sensing pathways. by Michael P. Siegel (195229)

“…Data are expressed as means ± SEM with n = 5–9 per group. AMPK data are normalized to control average. (* p<0.05 relative to control).…”

Metformin Affects Gut Microbiome Composition and Function and Circulating Short-Chain Fatty Acids: A Randomized Trial by Noel T. Mueller (10428583)

Molecular and electrophysiological characterization of LH^PV neurons. by Alexandre Kisner (1936639)

“…<i>2</i>, and <i>Hcn2</i> in single LH^PV neurons. Box plots show mean (×), median, quartiles (boxes), and s.e.m. (whiskers). …”