CBE and isofagomine effectively inhibit purified GBA1 at 1 mM and 1 μM, respectively. by Zdenek Berger (440685)

“…The graph shows a summary of three independent experiments. E) Addition of sodium taurocholate (NaTc) increases activity of GBA1 ~ 5-fold but decreases activity of GBA3 by ~ 50%. …”

Cytotoxicity of candidate agents to cholangiocarcinoma cells. by Chiara Braconi (235041)

“…All three compounds decreased cell viability in a concentration-dependent manner, with an IC50 for felodipine of 26±5 µM, nitrendipine, 44±10 µM and nifedipine, 15±4 µM. …”

Force-frequency relationship in zebrafish ventricular myocardium. by Moritz Haustein (734263)

Measurement of lysosome proteolytic and acidic functions in response to PIKfyve inhibition and ROS. by Golam T. Saffi (11747438)

“…Scale bar: 50 μm. (C) Quantification of Magic Red to Alexa488-dextran intensity ratio, where decreasing intensity ratio indicates reduced degradation. …”

Conditional RAX-Cre-mediated ablation of <i>Prss56</i> from fully differentiated Müller glia leads to ocular size reduction. by Seyyedhassan Paylakhi (4951933)

“…<i>Prss56</i>^<i>F/F</i><i>; Rax-Cre</i>^<i>ERT2</i> eyes were indistinguishable from control <i>Prss56</i>^<i>F/+</i><i>; Rax-Cre</i>^<i>ERT2</i> eyes at 2 months of age. (<b>B</b>, <b>C</b>) Following tamoxifen injection (TAM +; horizontal axis) at P8, <i>Prss56</i>^<i>F/F</i><i>Rax-Cre</i>^<i>ERT2</i> mice display a significant decrease in ocular axial length (<b>B</b>) and increase in retinal thickness (<b>C</b>) compared to control eyes (<i>Prss56</i>^<i>F/+</i><i>; Rax-Cre</i>^<i>ERT2</i> or <i>Prss56</i>^<i>F/F</i> mice without <i>Rax-Cre</i>^<i>ERT2</i>), N = 6 to 8 per group. …”

ISL inhibited VEGF-induced tube formation, invasion and migration. by Zhiyu Wang (282312)

Impairment of pronephros development upon indomethacin treatment. by Jens H. Westhoff (492734)

“…<p>(A) Overview of pronephric alterations in zebrafish larvae (50 hpf) following indomethacin administration for 24 hours. …”

Dose response inhibition of IP6K1 by TNP in the presence of different concentrations of ATP and IP6. by Michael Wormald (4631122)

“…The reaction was run with 400μM IP6 and 60nM IP6K1 for 30 minutes at 37°C. (B) IC₅₀ values decreased slightly from 24±1.5μM to 9.5±1.5μM as IP6 concentrations were increased from 50μM to 400μM. …”

Extraction and characterization of biofunctional lignocellulosic fibers from Pulicaria undulata plant and the effect of alkali treatment on their bio-physicochemical properties by Mohammed, Alsafran

“…In contrast, alkali-treated fibers showed a significant decrease in radical scavenging activity (almost 7–8 fold) and reducing power potential (6-fold) and exhibited no antifungal activity, potentially due to the loss of bioactive components such as lignin and essential oils. …”
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MSCs on endothelial ECM appeared more spindle-like morphology. by Ming-Kang Lee (4401568)

“…<p>(A) MSCs at passage 2 (upper panel, scale bar: 200 μm) and passage 4 (lower panel, scale bar: 50 μm) of each group showed various morphologies. …”

File S1 - Amelioration of Cancer Stem Cells in Macrophage Colony Stimulating Factor-Expressing U87MG-Human Glioblastoma upon 5-Fluorouracil Therapy by S. Chockalingam (504388)

“…Overexpression of MCSF did not induce 5-FU mediated apoptosis. (A–C) U87MG. (D–F) U87-MCSF. The results revealed that MCSF expression failed to induce apoptosis after treatment with 25 µM 5-FU (B, E) and 50 µM 5-FU (C, F) for five days. …”

FA and glucose oxidations in SCD1-overexpressed cardiac myocytes. by Hiroki Matsui (330019)

“…(B): On the other hand, glucose oxidation was significantly reduced in cardiac myocytes treated with PA (100 µM). (C): PA (50 to 100 µM) induced excessive FA oxidation was attenuated in cardiac myocytes transduced with a MOI of 20 of Ad-SCD1 (▪) in comparison with control cells transduced with Ad-LacZ (□). …”

Percent of CSCs in MCF-7 human breast cancer cells treated with hyperthermia and metformin. by Hyemi Lee (342537)

“…<p>(A) Cells were incubated with 0–5 mM metformin for 48 h at 37°C, dispersed to single cells and analyzed for CD44^high/CD24^low cells (CSCs) with FACS. …”

Data_Sheet_1_Life-long consumption of high level of fruits and vegetables reduces tumor incidence and extends median lifespan in mice.PDF by Weimin Guo (2634919)

“…Long-term FV supplementation reduced systemic inflammation and blood lipids.</p>Conclusion<p>We provide the first causal evidence that life-long intake of a diet, containing a high level and large variety of FV, decreases tumor incidence and extends median lifespan in mice fed a western-style high-fat diet. …”

Data_Sheet_1_Life-long consumption of high level of fruits and vegetables reduces tumor incidence and extends median lifespan in mice.PDF by Weimin Guo (2634919)

“…Long-term FV supplementation reduced systemic inflammation and blood lipids.</p>Conclusion<p>We provide the first causal evidence that life-long intake of a diet, containing a high level and large variety of FV, decreases tumor incidence and extends median lifespan in mice fed a western-style high-fat diet. …”

Impact of Global <i>Fxr</i> Deficiency on Experimental Acute Pancreatitis and Genetic Variation in the <i>FXR - Figure 2 </i> Locus in Human Acute Pancreatitis by Rian M. Nijmeijer (208613)

Thermal Energy Transport through Nonbonded Native Contacts in Protein by Tingting Wang (123983)

Data Sheet 2_Heterogeneity of ventricular action potentials in neonatal rat cardiomyocytes and methodological aspects of patch clamp measurements.pdf by Pascal Syren (20762843)

“…In a comparative literature research, we found that mean APD₉₀ in between 27.0 and 560.7 ms (own data 59.7 ± 5.8 ms) were described, with high variability and likely non-Gaussian distribution. …”

Data Sheet 1_Heterogeneity of ventricular action potentials in neonatal rat cardiomyocytes and methodological aspects of patch clamp measurements.docx by Pascal Syren (20762843)

“…In a comparative literature research, we found that mean APD₉₀ in between 27.0 and 560.7 ms (own data 59.7 ± 5.8 ms) were described, with high variability and likely non-Gaussian distribution. …”

Calpain mediated the cleavage of calcineurin in PAN-treated podocytes. by Fangrui Ding (659863)

“…(C, D) The expression of cleaved 45-kDa calcineurin was dependent on the increased concentration of PAN (25, 50, 75, 100, and 125 μg/ml) in podocytes and was associated with a dose-dependent decrease in 60-kDa calcineurin. …”