Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”

Mutation-Specific and Common Phosphotyrosine Signatures of <i>KRAS</i> G12D and G13D Alleles by Raiha Tahir (4723152)

“…When we compared the global phosphotyrosine proteomic profiles of isogenic colorectal cancer cell lines bearing either G12D or G13D <i>KRAS</i> mutation, we observed both shared as well as unique signaling events induced by the two <i>KRAS</i> mutations. …”

Mutation-Specific and Common Phosphotyrosine Signatures of <i>KRAS</i> G12D and G13D Alleles by Raiha Tahir (4723152)

“…When we compared the global phosphotyrosine proteomic profiles of isogenic colorectal cancer cell lines bearing either G12D or G13D <i>KRAS</i> mutation, we observed both shared as well as unique signaling events induced by the two <i>KRAS</i> mutations. …”

Decreasing fitness over time observed following analysis of paired isolates obtained from acute HIV-1 infection subjects, measured using QPCR. by Alicia Arnott (242179)

Image_2_Underdevelopment of gut microbiota in failure to thrive infants of up to 12 months of age.jpeg by Mei Zhang (46138)

“…<p>Laboratory and clinical studies have revealed the importance of gut microbiota in children with severe pediatric pathological conditions such as severe acute malnutrition (SAM); however, under relatively milder conditions such as, failure to thrive (FTT), the role of the gut microbiota remains poorly characterized. Here, we analyzed stool samples from 54 subjects with a clinical diagnosis of failure to thrive (FTT), 49 preterm subjects with corrected normal growth (NFTT-pre), and 49 healthy subjects (NFTT) between 3-12 months of age using 16S rRNA gene sequencing. …”

Image_1_Underdevelopment of gut microbiota in failure to thrive infants of up to 12 months of age.jpeg by Mei Zhang (46138)

“…<p>Laboratory and clinical studies have revealed the importance of gut microbiota in children with severe pediatric pathological conditions such as severe acute malnutrition (SAM); however, under relatively milder conditions such as, failure to thrive (FTT), the role of the gut microbiota remains poorly characterized. Here, we analyzed stool samples from 54 subjects with a clinical diagnosis of failure to thrive (FTT), 49 preterm subjects with corrected normal growth (NFTT-pre), and 49 healthy subjects (NFTT) between 3-12 months of age using 16S rRNA gene sequencing. …”

Table_1_Underdevelopment of gut microbiota in failure to thrive infants of up to 12 months of age.xlsx by Mei Zhang (46138)

“…<p>Laboratory and clinical studies have revealed the importance of gut microbiota in children with severe pediatric pathological conditions such as severe acute malnutrition (SAM); however, under relatively milder conditions such as, failure to thrive (FTT), the role of the gut microbiota remains poorly characterized. Here, we analyzed stool samples from 54 subjects with a clinical diagnosis of failure to thrive (FTT), 49 preterm subjects with corrected normal growth (NFTT-pre), and 49 healthy subjects (NFTT) between 3-12 months of age using 16S rRNA gene sequencing. …”

Table_2_Underdevelopment of gut microbiota in failure to thrive infants of up to 12 months of age.xlsx by Mei Zhang (46138)

“…<p>Laboratory and clinical studies have revealed the importance of gut microbiota in children with severe pediatric pathological conditions such as severe acute malnutrition (SAM); however, under relatively milder conditions such as, failure to thrive (FTT), the role of the gut microbiota remains poorly characterized. Here, we analyzed stool samples from 54 subjects with a clinical diagnosis of failure to thrive (FTT), 49 preterm subjects with corrected normal growth (NFTT-pre), and 49 healthy subjects (NFTT) between 3-12 months of age using 16S rRNA gene sequencing. …”

Normalized formulas and explanations. by Xianzhuang Shao (22766120)

“…By comparing the Brier scores, it was found that the models with better predictive performance were those using the SPEI-1 and SPEI-12 timescales. We also found that in the near and medium term of the future, with climate change, the forest fire occurrence probability in most forest land of northern China (NWC, NC, and NEC), especially in Northeast China (NEC), shows an increasing trend, but a decreasing trend in most forest land of southern China (SC, SWC, and EC). …”

Data_Sheet_1_Decreased circulating branched-chain amino acids are associated with development of Alzheimer’s disease in elderly individuals with mild cognitive impairment.docx by Takeshi Ikeuchi (397119)

Antibody-dependent cellular phagocytosis (ADCP) is boosted by RV305 vaccination and is associated with IgG1 binding response. by LaTonya D. Williams (3140490)

The mean and variance of the cable length can be independently controlled within the antenna model. by Lishibanya Mohapatra (759979)

“…Parameters used for the polymerization and depolymerisation rate were <i>r</i> = 370 s^-1, <i>d</i> = 45 s^-1, <i>k</i>_<i>off</i> = 0.5 s^-1(red) and 50 s^-1(blue); for chosen values of <i>k</i>_<i>off</i>, the rate <i>w</i> was calculated from <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004160#pcbi.1004160.e005" target="_blank">Eq 1</a> for the mean length. …”

The proportion of ALDH+ cells progressively increases while CGA+ cells markedly decreases in <i>APC</i>-mutant colon tissues from FAP patients. by Tao Zhang (43681)

“…<p>Representative IHC stains of normal, normal-appearing FAP, and FAP adenomatous colonic crypts are shown for the expression of the: <b>(A)</b> NEC marker chromogranin-A (CGA). <b>(B)</b> SC marker ALDH1. …”

Table12_Characterization and diagnostic value of the gut microbial composition in patients with minimal change disease.xlsx by Yiding Zhang (1428880)

Image_12_Rv3722c Promotes Mycobacterium tuberculosis Survival in Macrophages by Interacting With TRAF3.tif by Yingying Lei (10191419)

“…The interaction between Rv3722c and TRAF3 hampered MAPK and NF-κB pathways, resulting in a significant increase of IFN-β expression and decrease of IL-1β, IL-6, IL-12p40, and TNF-α expression. …”

UV-irradiated M phase-cells show decreased MCM 2–7 loading and G1 arrest after release: HeLa cells. by Masayuki Morino (304956)

ALVAC-HIV elicits V2, V3, and CD4 inducible (CD4i) binding antibody responses. by LaTonya D. Williams (3140490)