Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). Instead, only a subtle shift in the location of this water molecule resulted in a dramatic decrease in the energy of this high-energy hydration site, as shown by the WaterMap analysis combined with microsecond timescale molecular dynamics simulations. …”

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). Instead, only a subtle shift in the location of this water molecule resulted in a dramatic decrease in the energy of this high-energy hydration site, as shown by the WaterMap analysis combined with microsecond timescale molecular dynamics simulations. …”

Induction of histones H3 and H4 hyper-acetylation and decreased histone H3-lys27 trimethylation follow GBM cell line treatment with HYP. by Naama Dror (459005)

Estimates of the differencing parameter, d, in Eq (1). by Luis Alberiko Gil-Alana (14659817)

PGRP-LC in the gut promotes ageing by <i>A</i>. <i>persici</i>. by Taro Onuma (15195377)

miR-184 sensor expression across a range of tissues. by Sravya Paluri (5475260)

<i>Ss</i> infection is associated with decreased plasma levels of IL-2, IL-7 and IL-15 and enhanced plasma levels of IL-4 and IL-9. by Anuradha Rajamanickam (5278013)

Table_1_Increased Neutrophil Count and Decreased Neutrophil CD15 Expression Correlate With TB Disease Severity and Treatment Response Irrespective of HIV Co-infection.DOCX by Lerato N. Ndlovu (9315464)

TLR2 deficiency decreased TGF-β1 expression, phosphorylated Smad2/3 and myofibroblasts activation induced by <i>C</i>. <i>sinensis</i>. by Yuru Wang (846969)

Climate variable summary. by Dawn Robin Magness (6157265)

Functional characterization of skinned myocardium prepared from Epac1TG. by Yoshiki Ohnuki (576298)

Table_1_Prenatal exposure to inflammation increases anxiety-like behaviors in F1 and F2 generations: possible links to decreased FABP7 in hippocampus.DOCX by Jing Chen (4762)

“…<p>Anxiety disorder has a high prevalence, and the risk of anxiety increases with age. …”

A funnel plot shows the number of studies reporting a change in gut bacteria abundance in patients with an RTI compared to healthy participants. by Claire A. Woodall (10724917)

“…There were 5/5 reports of an ‘increase’ in <i>Enterococcus</i>, 5/5 reports of a ‘decrease’ in Ruminococcaceae and 6/6 reports of a ‘decrease’ in both Lachnospiraceae and <i>Ruminococcus</i> in patients with an RTI compared to healthy participants. …”

Positive (+) and negative (-) impacts of the Covid-19 pandemic on new mothers in the Covid-19 New Mum Study. by Adriana Vázquez-Vázquez (9672972)

Temperature field without considering insulation layer deterioration (2.6 °C). by Jianqing Jia (21001506)

Stress field of surrounding rock considering the insulation layer deterioration (2.6 °C). by Jianqing Jia (21001506)

Stress field of surrounding rock without considering insulation layer deterioration (2.6 °C). by Jianqing Jia (21001506)

Temperature field considering the insulation layer deterioration (2.6 °C). by Jianqing Jia (21001506)

Ecological trajectories. by Dawn Robin Magness (6157265)

S1 File - by Ruiming Xiao (6389546)

“…In this study, metabolomics analysis revealed a significant increase in the main contents of lactic acid and propionic acid in FCM, while most glycosides and their derivatives decreased after three days of microbial fermentation. …”