Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo by Zhiqiang Li (102723)

“…The overexpression of NIK plays a critical role in liver inflammatory diseases. …”

microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration - Fig 6 by Surjyadipta Bhattacharjee (3181674)

“…After vacuum evaporation of HFIP, aliquoted peptide was re-suspended with DMSO to 5 mM and diluted to 5 μM into the cell culture media; <b>(B)</b> cells were treated with a scrambled miRNA-34a sequence (miRNA-34a-<b>sc</b>; 30 nM;, control, <b>a-d</b>, middle row); or <b>(C)</b> with an LNA-stabilized miRNA-34a (30 nM; miRNA-34a stressed; <b>a-d</b>; bottom row); treatments were for 24 hr before incubation with 5 uM of Aβ42 (made up as in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref033" target="_blank">33</a>]) for another 24 hr before assay; MG cells were subsequently stained using a murine amyloid beta MABN10 (red fluorescence λ_max~650 nm; anti-Aβ antibody, clone W0-2; Millipore, Bellerica MA), a TREM-2 antibody (M-227): sc-48765 (green fluorescence; λ_max~510 nm; Santa Cruz, Santa Cruz CA) or DAPI nuclear stain (blue fluorescence; λ_max~470 nm) as in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.g003" target="_blank">Fig 3</a>;</b> arrows indicate Aβ42 uptake into MG cells; note decreased presence of TREM2 in miRNA-34a treated MG cells (bottom row, panel B) and decrease in ingested Aβ42 peptide within C8B4 cells (<b>C</b>; bottom row, panel <b>d</b>). …”

Disruption of the viral cyclin has no effect on the frequency of viral genome positive cells yet results in a reduced frequency of LANA::βla+ cells. by Brian F. Niemeyer (11707995)

Twenty-two identified and replicated loci and their overlap with associations to metabolic traits and clinical phenotypes. by Johannes Raffler (793347)

“…We added their proxy variants in LD (r² ≥ 0.8; based on 1000 genomes project data [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005487#pgen.1005487.ref050" target="_blank">50</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005487#pgen.1005487.ref051" target="_blank">51</a>]). …”

Video_1_Stability of Zircon and Its Isotopic Ratios in High-Temperature Fluids: Long-Term (4 months) Isotope Exchange Experiment at 850°C and 50 MPa.mov by Ilya N. Bindeman (2843150)

“…Here, we report results of a nano- to micrometer-scale investigation of isotopic exchange using natural zircon from Mesa Falls Tuff (Yellowstone) treated with quartz-saturated, isotopically (¹⁸O, D, ⁷Li, and ¹¹B) labeled water with a nominal δ¹⁸O value of +450%0 over 4 months at 850°C and 50 MPa. …”

Presentation_1_Stability of Zircon and Its Isotopic Ratios in High-Temperature Fluids: Long-Term (4 months) Isotope Exchange Experiment at 850°C and 50 MPa.pdf by Ilya N. Bindeman (2843150)

“…Here, we report results of a nano- to micrometer-scale investigation of isotopic exchange using natural zircon from Mesa Falls Tuff (Yellowstone) treated with quartz-saturated, isotopically (¹⁸O, D, ⁷Li, and ¹¹B) labeled water with a nominal δ¹⁸O value of +450%0 over 4 months at 850°C and 50 MPa. …”

Table_1_Stability of Zircon and Its Isotopic Ratios in High-Temperature Fluids: Long-Term (4 months) Isotope Exchange Experiment at 850°C and 50 MPa.XLS by Ilya N. Bindeman (2843150)

“…Here, we report results of a nano- to micrometer-scale investigation of isotopic exchange using natural zircon from Mesa Falls Tuff (Yellowstone) treated with quartz-saturated, isotopically (¹⁸O, D, ⁷Li, and ¹¹B) labeled water with a nominal δ¹⁸O value of +450%0 over 4 months at 850°C and 50 MPa. …”

Preliminary dose-response experiments. by Noelia Torremadé (3687523)

Defects in the conduction of somatosensory evoked potentials of median and tibial nerves in a healthy child and in H-ABC patient. by Jose R. Eguibar (8563227)

Simulated average monthly flow at the 10 outflow assessment nodes in the five river basins over the 2008 to 2020 period (HMRB: Harirod-Murghab River Basin, HRB: Helmand River Basin... by Fazlul Karim (7225826)

Pre-diabetes is associated with increased risk of heart failure among patients with atrial fibrillation by Jia-Yi Huang (12733928)

“…Compared to those who remained pre-diabetic, patients who progressed to diabetes were associated with an increased risk of HF (SHR=1.50, 95% CI: 1.13-1.97), whereas those who reversed to normoglycaemia were associated with decreased risk (SHR=0.61, 95% CI: 0.42-0.94). …”

Investigation of mechanisms underlying NMR-detected changes in the levels of choline metabolites and lactate following treatment of SF188 pediatric glioblastoma cells with PI-103 (... by Nada M. S. Al-Saffar (454143)

Position of committed effective dose <i>E</i>_U+LS between <i>E</i>_LS and <i>E</i>_U (Bq d^–1). by Martin Šefl (11607984)

A complete set of mathematical model equations utilized in ILYCM software to develop S. <i>frugiperda</i> phenology for each life stage. by Marian Adan (16641634)

Fig 2 - by Muhammad Imran Nisar (10226212)

Individual serotype carriage rates over the study period. by Muhammad Imran Nisar (10226212)

The carriage rate of VT serotypes by number of doses of vaccine. by Muhammad Imran Nisar (10226212)

Serotype specific carriage rate from 2014–18 in Matiari, Pakistan. by Muhammad Imran Nisar (10226212)

Serotype-specific carriage rate by vaccination status. by Muhammad Imran Nisar (10226212)

SEM images of lattice scaffolds; A) 4 layers, B) 6 layers, C) 8 layers, D) 10 layers, and staggered scaffolds; E) 4 layers, F) 6 layers, G) 8 layers, H) 10 layers. by Zahra Yazdanpanah (10038944)