Bone resorption. by Bo Huang (30906)

“…<p>3A shows the results of the bone resorption assay: Raw264.7 cells plated on bovine cortical bone slices were differentiated into osteoclasts by the addition of 50ng/ml of Rankl and 20ng/ml of M-CSF in the presence or absence of 50ng/ml Sema3a and/or 2Gy radiation. …”

<i>Cited1</i> deficiency increases enterocyte proliferation and decreased cell migration in <i>AhCre⁺Apc^fl/fl</i> mice. by Valérie Méniel (440547)

Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the... by Jing Liao (193197)

“…The optimal compound <b>J27</b> decreased the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC₅₀ = 0.22 μM) through the NF-κB/MAPK pathway. …”

Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the... by Jing Liao (193197)

“…The optimal compound <b>J27</b> decreased the release of TNF-α and IL-6 in mouse and human cells J774A.1 and THP-1 (IL-6 IC₅₀ = 0.22 μM) through the NF-κB/MAPK pathway. …”

Two different simulated fibre length distributions for flax based on the actual fibre lengths prior to hydrolysis. by Lisbeth G. Thygesen (631259)

“…In the simulation in B), the parameter M_u/P was set to 400 in step 1 and to decrease by 25% in each step until it reached 40.…”

DataSheet_1_Decreasing the steroid rapidly may help to improve the clinical outcomes of patients with intestinal steroid-refractory acute graft-versus-host disease receiving basili... by Cong Cheng (2140318)

“…Hence, it was helpful to decrease steroid to the 50% of initial dose ≤ 5 days and to the low-dose steroid ≤ 12 days after basiliximab treatment for intestinal SR-aGVHD patients, which may also be the reasonable steroid decrease protocol for these patients.…”

Developmental regulation of BLBP-positive radial glia and BrdU-positive proliferative cells in the <i>Xenopus</i> tectum. by Yi Tao (178829)

“…Right panel: a higher magnification image of the right tectum, Scale: 50 μm. …”

Analysis of AMPA-R mediated EPSCs (aEPSCs) at CA1 synapses in hippocampal slices from P10 mice ICV injected at P1, P3, and P5 with saline or GR1. by Nicole M. Lykens (3727072)

“…Representative traces of maximal aEPSCs are shown from saline and GR1-treated mice (scale bars: 50 ms; 200 pA). …”

Decreased astrocytic Kir4.1 channel conductance <i>g</i>_<i>kir</i> induces spontaneous periodic epileptic seizures in the absence of external stimuli. by Mengmeng Du (281306)

Compared to the wild type, overexpression of <i>GhCPC</i> leads to delayed fiber differention and decreased fiber length in the T3 generation Wild type was separated from the T0 ge... by Bingliang Liu (188563)

Steady-state concentration dependence of the effect of nicotine on <i>I</i>_{KAch_ACH} at -50 mV (above) and -110 mV (below) on a relative scale (currents under nicotine re... by Jiří Šimurda (7486118)

Transgenerational alteration and inheritance of DNA methylation patterns in 20 randomly chosen S2 plants derived from two S1 individual plants, S1(#4) and S1(#11) which were derive... by Xiufang Ou (136093)

The effect of isoalantolactone on the cell cycle in UM-SCC-10A cells. by Minjun Wu (464934)

“…The representative histograms are from UM-SCC-10A cells incubated with different concentration of isoalantolactone (25 and 50 µM) or caspase inhibitor (Z-VAD-FMK50 µM). …”

Combining RT and αCD47 reduced tumor volume and increased survival rates. by Elham Rostami (339949)

The heterogeneity of TAS2R inhibition of [Ca²⁺]_i is recapitulated in HASM physiological responses. by Blanca Camoretti-Mercado (762326)

Short-term insulin intensive therapy decreases MCP-1 and NF-κB expression of peripheral blood monocyte and the serum MCP-1 concentration in newlydiagnosed type 2 diabetics by Yang Lin (162495)

“…Results After 2 weeks of the treatment, MCP-1 and NF-κB protein expression of peripheral blood monocyte and serum MCP-1 levels decreased significantly compared with those of pre-treatment, which were (0.50 ± 0.18)% vs (0.89 ± 0.26)% (12.22 ± 2.80)% vs (15.53 ± 2.49)% and (44.53 ± 3.97) pg/mL vs (49.53 ± 3.47) pg/mL, respectively (P < 0.01). …”

Short-term insulin intensive therapy decreases MCP-1 and NF-κB expression of peripheral blood monocyte and the serum MCP-1 concentration in newlydiagnosed type 2 diabetics by Yang Lin (162495)

“…Results After 2 weeks of the treatment, MCP-1 and NF-κB protein expression of peripheral blood monocyte and serum MCP-1 levels decreased significantly compared with those of pre-treatment, which were (0.50 ± 0.18)% vs (0.89 ± 0.26)% (12.22 ± 2.80)% vs (15.53 ± 2.49)% and (44.53 ± 3.97) pg/mL vs (49.53 ± 3.47) pg/mL, respectively (P < 0.01). …”

Data Sheet 2_An exploratory analysis of bezisterim treatment associated with decreased biological age acceleration, and improved clinical measure and biomarker changes in mild-to-m... by Christopher L. Reading (21236861)

Data Sheet 1_An exploratory analysis of bezisterim treatment associated with decreased biological age acceleration, and improved clinical measure and biomarker changes in mild-to-m... by Christopher L. Reading (21236861)

Interaction Patterns between Climate Action and Air Cleaning in China: A Two-Way Evaluation Based on an Ensemble Learning Approach by Zeyuan Liu (11399456)

“…Identifying interaction patterns between air cleaning and climate action represents an important step to obtain cobenefits. Here, we used a random sampling strategy through the combination of chemical transport modeling and machine learning approach to capture the interaction effects from two perspectives in which the driving forces of both climate action and air cleaning measures were compared. …”