Astragaloside IV reduced oxidative stress in SH-SY5Y cells and decreased iNOS expression in BV-2 cells upon IFNγ stimulation. by Yixin He (466799)

Supplementary Data S2 from SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance by Kristen Jensen-Pergakes (15090247)

HbA1c, BMI and Lipid levels of study participants (n = 382). by Habiba I. Ali (10451382)

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). Instead, only a subtle shift in the location of this water molecule resulted in a dramatic decrease in the energy of this high-energy hydration site, as shown by the WaterMap analysis combined with microsecond timescale molecular dynamics simulations. …”

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). Instead, only a subtle shift in the location of this water molecule resulted in a dramatic decrease in the energy of this high-energy hydration site, as shown by the WaterMap analysis combined with microsecond timescale molecular dynamics simulations. …”

Induction of histones H3 and H4 hyper-acetylation and decreased histone H3-lys27 trimethylation follow GBM cell line treatment with HYP. by Naama Dror (459005)

Estimates of the differencing parameter, d, in Eq (1). by Luis Alberiko Gil-Alana (14659817)

PGRP-LC in the gut promotes ageing by <i>A</i>. <i>persici</i>. by Taro Onuma (15195377)

miR-184 sensor expression across a range of tissues. by Sravya Paluri (5475260)

SEAwise Report on consistent targets and limits for indicators in an ecosystem context by Alexander Kempf (11493739)

“…Sustainable management of stocks was still possible under climate change, but productivity declines of cod and saithe will drive declines of indicators of large fish with a subsequent need to adapt the thresholds. The ecosystem models predicted a negative impact of climate change on primary production and a decreasing efficiency of energy transfer up the food web. …”

<i>Ss</i> infection is associated with decreased plasma levels of IL-2, IL-7 and IL-15 and enhanced plasma levels of IL-4 and IL-9. by Anuradha Rajamanickam (5278013)

Table_1_Increased Neutrophil Count and Decreased Neutrophil CD15 Expression Correlate With TB Disease Severity and Treatment Response Irrespective of HIV Co-infection.DOCX by Lerato N. Ndlovu (9315464)

TLR2 deficiency decreased TGF-β1 expression, phosphorylated Smad2/3 and myofibroblasts activation induced by <i>C</i>. <i>sinensis</i>. by Yuru Wang (846969)

Climate variable summary. by Dawn Robin Magness (6157265)

Functional characterization of skinned myocardium prepared from Epac1TG. by Yoshiki Ohnuki (576298)

Table_1_Prenatal exposure to inflammation increases anxiety-like behaviors in F1 and F2 generations: possible links to decreased FABP7 in hippocampus.DOCX by Jing Chen (4762)

“…<p>Anxiety disorder has a high prevalence, and the risk of anxiety increases with age. …”

A funnel plot shows the number of studies reporting a change in gut bacteria abundance in patients with an RTI compared to healthy participants. by Claire A. Woodall (10724917)

“…There were 5/5 reports of an ‘increase’ in <i>Enterococcus</i>, 5/5 reports of a ‘decrease’ in Ruminococcaceae and 6/6 reports of a ‘decrease’ in both Lachnospiraceae and <i>Ruminococcus</i> in patients with an RTI compared to healthy participants. …”

Positive (+) and negative (-) impacts of the Covid-19 pandemic on new mothers in the Covid-19 New Mum Study. by Adriana Vázquez-Vázquez (9672972)

Temperature field without considering insulation layer deterioration (2.6 °C). by Jianqing Jia (21001506)

Stress field of surrounding rock considering the insulation layer deterioration (2.6 °C). by Jianqing Jia (21001506)