Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (<i>S</i>, <i>Se</i>) and Their Azole Derivatives against Chagas Disease by Mercedes Rubio-Hernández (20036142)

“…Seleno-compounds demonstrated enhanced activity and selenazoles showed a decrease in selenium-associated toxicity. Compound 4-methyl-2-(2-(1-(3-nitrophenyl)­ethylidene)­hydrazineyl)-1,3-selenazole (<i><b>Se</b></i><b>2h</b>) emerged as a promising candidate, and its binding to cruzain was investigated. …”

Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (<i>S</i>, <i>Se</i>) and Their Azole Derivatives against Chagas Disease by Mercedes Rubio-Hernández (20036142)

“…Seleno-compounds demonstrated enhanced activity and selenazoles showed a decrease in selenium-associated toxicity. Compound 4-methyl-2-(2-(1-(3-nitrophenyl)­ethylidene)­hydrazineyl)-1,3-selenazole (<i><b>Se</b></i><b>2h</b>) emerged as a promising candidate, and its binding to cruzain was investigated. …”

Dys regulates <i>rpr</i> expression and apoptosis. by Sergio Córdoba (645937)

“…Asterisk marks the tip of the leg where endogenous high levels of DCas-3 are observed. (E–F) Close sagittal view of one tarsal joint in a wild type (E) and <i>dys²/dys³</i> mutant prepupal legs where the domains of <i>E(spl)mβ-CD2</i> (red) and the “fold” domain (between the two <i>E(spl)mβ-CD2</i>) are visible. …”

Validation of NUMB as a target for <i>miR-146a</i>. by Pei-Shi Hung (489732)

Image_1_Extracellular Vesicles Carry lncRNA SNHG16 to Promote Metastasis of Breast Cancer Cells via the miR-892b/PPAPDC1A Axis.TIFF by Wenfei Xia (5055482)

Anti-inflammatory Meroterpenoids from <i>Baeckea frutescens</i> by Ji-Qin Hou (3642946)

“…Compound <b>8</b> exhibited anti-inflammatory activity with an IC₅₀ value of 0.36 μM, which might be related to the regulation of the NF-κB signaling pathway via the suppression of p65 nuclear translocation and the consequent decrease of IL-6 and TNF-α.…”

Anti-inflammatory Meroterpenoids from <i>Baeckea frutescens</i> by Ji-Qin Hou (3642946)

“…Compound <b>8</b> exhibited anti-inflammatory activity with an IC₅₀ value of 0.36 μM, which might be related to the regulation of the NF-κB signaling pathway via the suppression of p65 nuclear translocation and the consequent decrease of IL-6 and TNF-α.…”

Anti-inflammatory Meroterpenoids from <i>Baeckea frutescens</i> by Ji-Qin Hou (3642946)

“…Compound <b>8</b> exhibited anti-inflammatory activity with an IC₅₀ value of 0.36 μM, which might be related to the regulation of the NF-κB signaling pathway via the suppression of p65 nuclear translocation and the consequent decrease of IL-6 and TNF-α.…”

High blood glucose levels in rats after exposure to STZ. by Shatw Khalid Ali (13020885)

Potent 5‑Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1–UBE2M Interaction by Wenjuan Zhou (115285)

“…After finding a novel inhibitor <b>DC-1</b> with IC₅₀ = 1.2 μM, we performed a series of chemical optimizations, which finally led to the discovery of a potent thiazole containing 5-cyano-6-phenylpyrimidin-based inhibitor <b>DC-2</b> (IC₅₀ = 15 nM). …”

Parameters of the LV geometry model. by Shiro Kato (2444047)

“…On the other hand, end-systolic elastance (<i>E</i>_<i>max</i>) is known to be a good index of LV contractility, which is measured by the slope of several end-systolic <i>P</i>_<i>lv</i>—<i>V</i>_<i>lv</i> points obtained by using different loads. …”

The effects of metformin, donepezil, insulin glargine, and glibenclamide on brain biomarkers: Amyloid β 42, nitric oxide, acetylcholinesterase, malondialdehyde, β secretase, and pM... by Shatw Khalid Ali (13020885)

A trial of seven footfalls in which the subject (emu) underwent a gradual deceleration. by P. J. Bishop (4219759)

Activity of miR-124 and miR-23a in NSC-derived neurons and astrocytes. by Annalisa Lattanzi (427545)

“…(B–E) A significant decrease of GFP expression is observed in bdLV.miRT124-transduced neurons (βtubIII, MAP2) (<b>B, C</b>) and in bdLV.miRT23a-transduced astrocytes (GFAP) and immature glial cells (nestin) (<b>D, E</b>). …”

The effect of glibenclamide on channel activity at +20, 0 and -20 mV. by Sajjad Salari (736104)

“…Histogram bars show current amplitudes and P_o of reconstituted channels in absence or presence of glibenclamide. The addition of 50 μM glibenclamide resulted in a decreased current jump amplitude and a reduction in P_o. 100 μM glibenclamide caused a total channel inhibition at +20 and 0 mV (n = 5), but was ineffective at -20 mV. …”

Crystal Structure of YbCu₆In₆ and Mixed Valence Behavior of Yb in YbCu_6–<i>x</i>In_6+<i>x</i> (<i>x</i> = 0, 1, and 2) Solid Solution by Udumula Subbarao (1431364)

“…A deviation in inverse susceptibility data at 200 K suggests a valence transition from Yb²⁺ to Yb³⁺ as the temperature decreases. …”

Effects of VPA on zebrafish survival, hatching status, and development. by Sangwoo Lee (1727713)

Annual total intake of cats per shelter. by W. J. R. van der Leij (7495688)

Image_3_DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation.tif by Majd Jawad (12157533)

“…By data mining with publicly accessible cancer genomics databases and a clinical genomic database from a tertiary medical institution, DNMT3A R882 mutations were found to be enriched in AML (53% of all DNMT3A mutations) but decreased in frequency in clonal hematopoiesis of indeterminate potential (CHIP) (10.6%) or other myeloid neoplasms including MDS (27%) (p<.001). …”

Image_1_DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation.tif by Majd Jawad (12157533)

“…By data mining with publicly accessible cancer genomics databases and a clinical genomic database from a tertiary medical institution, DNMT3A R882 mutations were found to be enriched in AML (53% of all DNMT3A mutations) but decreased in frequency in clonal hematopoiesis of indeterminate potential (CHIP) (10.6%) or other myeloid neoplasms including MDS (27%) (p<.001). …”