Trichopsistides A and B: Two Highly Oxygenated Pentacyclic Polyketides with Promising Inhibitory Effects on the NF-κB Signaling Pathway from the Fungus <i>Trichoderma koningiopsis<... by Li Feng (77923)

“…Two highly oxygenated pentacyclic polyketides with two new carbon skeletons, trichopsistide A (<b>1</b>) and trichopsistide B (<b>2</b>), were isolated from the plant endophyte <i>Trichoderma koningiopsis</i> WZ-196 derived from the leaf of <i>Rubia podantha</i> Diels. …”

Simvastatin alters actin organization, cell morphology, and Rac1 activity in endothelial monolayers. by Marsha C. Lampi (845609)

“…Cell circularity, where a perfectly circular cell has a value of 1, decreases with increasing simvastatin concentration (n = 3, 50–54 cells per condition). …”

A study of the abundance of species in grassland-to-pond transition zone and impermeable ground habitats by Helen Musulan (3119433)

“…The survey involved running a transect for 50m (parallel to the pond) and a surveyor visually inspecting and counting for the above listed species in an area within a 50m radius of the transect start point. …”

Clinical outcomes and mortality in old and very old patients undergoing cardiac resynchronization therapy by Luiz Eduardo Montenegro Camanho (8066762)

“…<div><p>Aim</p><p>Cardiac resynchronization therapy (CRT) is a valid therapeutic option for patients with heart failure (HF). …”

Table_1_Guanidine acetic acid exhibited greater growth performance in younger (13–30 kg) than in older (30–50 kg) lambs under high-concentrate feedlotting pattern.docx by Wen-Juan Li (1444948)

“…In a brief, the results obtained in the present study suggested that GAA (UGAA and CGAA; 1 g/kg DM) could be applied to improve growth performance in younger (13–30 kg) instead of older (30–50 kg) lambs in high-concentrate feedlotting practice.…”

Discovery of PMSA Derivative <b>11</b> as a Novel Lead Compound for Therapeutic Treatment of Osteoporosis <i>In Vitro</i> and <i>In Vivo</i> by Zhihao Chen (513264)

“…Additionally, <b>11</b> blocked the formation of F-action belts and bone resorption in a concentration-dependent manner. Mechanistically, <b>11</b> decreased the expression of genes required for osteoclastogenesis by blocking NFATc1 translocation from the cytoplasm to nucleus. …”

Penidaleodiolides A and B, Cage-Like Polyketides with Neurotransmission-Regulating Activity from the Soil Fungus <i>Penicillium daleae</i> L3SO by Qing-Yuan Wang (11571890)

“…The hypothetical biosynthetic pathways for <b>1</b> and <b>2</b> were postulated and were supported by CRISPR/Cas9 genome editing results. Penidaleodiolide A (<b>1</b>) showed a significant inhibitory effect on the action potentials of murine hippocampal basket neurons and decreased the frequency of spontaneous excitatory postsynaptic currents in a concentration-dependent manner (the inhibition ratios were 0.30 ± 0.02 for 1 μM, 0.37 ± 0.03 for 10 μM, and 0.50 ± 0.07 for 20 μM) while being devoid of cytotoxicity against the nerve cells.…”

Analysis of fatty infiltration in muscle MRIs. by Sebastián Figueroa-Bonaparte (3202491)

“…We observed predominant fatty infiltration in the posterior muscles of the thighs producing decreased strength in the knee flexion test. (C) There was a strong correlation between knee flexion strength and the degree of muscle fatty infiltration calculated both using 3-point Dixon (left) and the Mercuri scale (right). …”

A novel second-generation platinum derivative and evaluation of its anti-cancer potential by Habibe Yilmaz (4865200)

“…In this study, cis-4-hydroxyphenylplatinum (II) diamine was synthesized with a yield of 62%. The MTT assay on A549-Luc and SKOV3-Luc cell lines resulted in IC50 values of 17.82 and 7.81 μM, respectively. …”

Machine learning models and univariate analyses discriminating non-severe and severe COVID-19 patients. by Gamalat A. Elgedawy (18700038)

Machine learning models and univariate analyses discriminating HC from non-severe COVID-19 patients. by Gamalat A. Elgedawy (18700038)

Machine learning models and univariate analyses discriminating severe and critical COVID-19 patients. by Gamalat A. Elgedawy (18700038)

Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2 by Marta E. Capala (652765)

“…Downregulation of SAM50 also impaired the proliferation and replating capacity of BCR-ABL-expressing cells, again associated with a decreased mitochondrial membrane potential. …”

Failure time prediction results of thawed sandstone with different freezing temperatures: by Liang Zhang (41392)

MOLM14 cells incubated with Eltrombopag for 6 hours show higher expression of stress response genes. by Anna Kalota (7415)

Effects of ROCK inhibitors H-1152 and Y-27632 on TNF-induced MLC phosphorylation, actin and CL5 reorganization and the fall in TEER. by Paul R. Clark (714064)

Analysis of Research Activity in Gastroenterology: Pancreatitis Is in Real Danger - Fig 2 by Andrea Szentesi (3239193)

High-frequency (HF) EP DBS produces frequency band-specific and time-dependent increases and decreases in LFP oscillation power in primary motor cortex (M1), striatum (STR) and ven... by Clinton B. McCracken (599113)

Analysis of requirement for MYPT1 expression in TNF-induced MLC phosphorylation and leak. by Paul R. Clark (714064)

IFN-γ counter-regulates hepatic fetuin-A expression. by Wei Li (7081)

“…<p><b>A</b>). <i>IFN-γ decreased fetuin-A expression levels in hepatocytes</i>. …”