Chronic Exposure to Perfluorooctane Sulfonate Induces Behavior Defects and Neurotoxicity through Oxidative Damages, <i>In Vivo</i> and <i>In Vitro</i> by Na Chen (153323)

“…However, the neurotoxicity of PFOS and its mechanisms have not been fully elucidated. Using a combination of <i>in vivo</i> and <i>in vitro</i> methods, the present study provides a detailed description of PFOS-induced neurotoxicity. …”

The BBB neocentromere contains a major and a minor centromere chromatin domain by Alicia Alonso (45373)

“…The adjacent megabase on either side of the central region, shown at a 10 fold reduced scale, was covered by PCR fragments at decreasing density. …”

Effects of functionalized multi-walled carbon nanotubes on toxicity and bioaccumulation of lead in <i>Daphnia magna</i> by Min-Hee Jang (827908)

“…The negatively charged C-MWCNT showed a notable decrease in lead toxicity (LC₅₀ value increased from 0.15 mg L^-1 to 1.08 mg L^-1 in the presence of 10 mg L^-1 C-MWCNT), whereas the positively charged N-MWCNT had only a slight effect on lead toxicity (LC₅₀ value increased from 0.15 mg L^-1 to 0.16 mg L^-1 in the presence of 10 mg L^-1 N-MWCNT). …”

Specific effects of OP2113 on ROS/H₂O₂ production at different sites in isolated rat heart mitochondria. by Dominique Detaille (3768979)

The lack of an effect of OP2113 on mitochondrial oxidative phosphorylation. by Dominique Detaille (3768979)

Bi-L-RhamBet induces growth inhibition of healthy and cancer cell lines. by Mouadh Mihoub (4962133)

“…<p>Survival of human healthy lung cell lines (MRC-5; HEL299), mouse Lewis lung cancer cells (LLC1), and human non-small cell lung cancer cells of different stages including: A549, NCI-H23, NCI-H2087 (stage 1), NCI-H522 (stage 2), NCI-H1993 (stage 3a), and NCI-H1755 (stage 4) all decrease with increased concentrations of Bi-L-RhamBet. …”

Depletion of RipA results in a reversible arrest in growth of <i>M. smegmatis.</i> by Erik C. Hett (244859)

“…Bacteria were visualized with a 100× objective. (D) Depletion strains of <i>M. smegmatis</i> grown on plates containing a gradient of inducer created by placing 10 µl of 10 ng/ml Tet on a paper disc in the center of the plate, resulting in a concentration of inducer highest at the middle of the plate and lowest at the edges. …”

Evaluation of safety and immunogenicity of a group A streptococcus vaccine candidate (MJ8VAX) in a randomized clinical trial by Silvana Sekuloski (209827)

“…Participants were randomized 4:1 to receive the vaccine candidate (N = 8) or placebo (N = 2). A single dose of the vaccine candidate (MJ8VAX), contained 50 μg of peptide conjugate (J8-DT) adsorbed onto aluminium hydroxide and re-suspended in PBS in a total volume of 0.5 mL. …”

Main sites of oxygen radical production by isolated mitochondria. by Dominique Detaille (3768979)

Flexible Reaction Pocket on Bulky Diphosphine–Ir Complex Controls Regioselectivity in <i>para</i>-Selective C–H Borylation of Arenes by Brandon E. Haines (1312221)

“…It is shown that an increase in the steric bulk of the ligand by introducing bulkier 3,5-substituents to the phenyl rings of the diarylphosphino groups of <b>L1</b> <i>decreases</i> the <i>para</i>-selectivity. This computational prediction was validated by experiments on C–H borylation of trimethyl­(phenyl)­silane by using the 3,5-di-<i>tert</i>-butylphenyl analogue of MeO-BIPHEP (<b>L3</b>) as a diphosphine ligand that showed a <i>decrease</i> in <i>para</i>/<i>meta</i> ratio from 88:12 (<b>L1</b>) to 50:50 (<b>L3</b>). …”

Effect of OP2113 on ROS/H₂O₂ production by isolated rat heart mitochondria. by Dominique Detaille (3768979)

Predictive value of clinical and laboratory features for the main febrile diseases in children living in Tanzania: A prospective observational study by Olga De Santis (3993422)

“…</p><p>Conclusion</p><p>A better understanding of the relative performance of these predictors might be of great help for clinicians to be able to better decide when to test, treat, refer or simply observe a sick child, in order to decrease morbidity and mortality, but also to avoid unnecessary antimicrobial prescription. …”

DataSheet_1_Effects of lipids on the rate-limiting steps in the dark-to-light transition of Photosystem II core complex of Thermostichus vulcanus.docx by Melinda Magyar (18191443)

“…<p>In our earlier works, we have shown that the rate-limiting steps, associated with the dark-to-light transition of Photosystem II (PSII), reflecting the photochemical activity and structural dynamics of the reaction center complex, depend largely on the lipidic environment of the protein matrix. Using chlorophyll-a fluorescence transients (ChlF) elicited by single-turnover saturating flashes, it was shown that the half-waiting time (Δτ_1/2) between consecutive excitations, at which 50% of the fluorescence increment was reached, was considerably larger in isolated PSII complexes of Thermostichus (T.) vulcanus than in the native thylakoid membrane (TM). …”

Membrane permeability of niosomes and liposomes. by Rianne Bartelds (1343631)

“…E: Stability of liposomes and niosomes filled with the fluorescent dye calcein (5 mM) after osmotic upshift by glycerol. At 50s (indicated by a black arrow), 0.667 M glycerol was added (osmolarity comparable to that of 0.4M KCl); line color as indicated under B. …”

Expression of ManB and GusA in <i>L</i>. <i>casei</i> MCJΔ1. by Jinzhong Lin (189430)

“…<i>casei</i> MCJΔ1/pELX1-ManB transformant were 0.2, 0.5, 1.0, 1.8, 2.9, 4.3, 5.0 and 6.7, and those of <i>L</i>. <i>casei</i> MCJΔ1/pELX1-GusA transformant were 0.2, 0.5, 1.0, 2.2, 3.6, 4.6, 5.8 and 6.6, respectively. …”

Western blot detection of ManB and GusA in <i>L</i>. <i>casei</i>. by Jinzhong Lin (189430)

“…<i>casei</i> MCJΔ1 transformant at different cell densities (OD₆₀₀ = 1.0, 1.8, 2.9, 4.3, 5.0 and 6.7). (<b>B</b>) Western blot of His-tagged GusA from the <i>L</i>. …”

The effects of metformin, donepezil, insulin glargine, and glibenclamide on serum biomarkers: Glucose, HbA1c, lipid profile, IL6, TNFa, amyloid β 42, total plasma tau, and NFL. by Shatw Khalid Ali (13020885)

Demonstration that SP-1 and SP-3 negatively regulates the PP2A-Aα promoter. by He-Ge Chen (90952)

“…Expression of the exogenous pCMV-SP-1 in both types of ocular cells attenuated expression of the endogenous gene coding for PP2A-Aα. F. Expression of the exogenous SP-3 in both types of ocular cells induced only slight decrease in the luciferase reporter gene activity within 0 to 500 ng of the pCMV-SP-3 plasmid, which is not statistically significant. …”

Effect of ELX-02 in <i>CTNS</i>^{<i>Y226X/Y226X</i>} mice. by Emma J. Brasell (8081969)

“…<p><b>A</b>. Half-cystine measurements show decrease pathologic accumulation in kidneys of <i>Ctns</i>^{<i>Y226X/Y226X</i>} mice treated with 7 injections of ELX-02 (10 mg/kg) over a 3-week period. …”

Analysis of (-)-epigallocatechin gallate (2.5 mmol/L) upon titration with salivary mucin. by Judith Delius (3813784)