Capsaicin inhibited the proliferation of human SCLC cells in a time- and concentration-dependent manner. by Kathleen C. Brown (365508)

“…<p>(A) MTT assays show at the treatment of H69 and H82 cells with 50 µM capsaicin causes a decrease in cell viability starting from 24 hours to 72 hours. …”

SSD - a free software for designing multimeric mono-, bi- and trivalent shRNAs by Gabriel José de Carli (8526942)

“…RT-qPCR analysis revealed that our molecule promoted a decrease in more than 50% of the target mRNA, in a dose-dependent manner, when compared to the control group. …”

CADA selectively and reversibly down-modulates human CD4 in a dose-dependent way. by Kurt Vermeire (12563)

“…Cells were harvested at specified time points and analyzed for surface CD4 expression by flow cytometry. Data represent mean values from two different donors. (H) Kinetics of CD4 down-modulation showing a slow but steady removal of surface CD4 with CADA, and a fast but transient decrease in CD4 with PMA. …”

High-Resolution Recombination Patterns in a Region of Human Chromosome 21 Measured by Sperm Typing by Irene Tiemann-Boege (34093)

Cyclin G2 is a target molecule of Cn/NFATc2 in follicular keratinocytes. by Atsushi Fujimura (227683)

“…<p>(A) The microarray analysis identified 24 genes that showed down-regulated expression in PHK cells treated with either 11R-VIVIT or CsA; <i>ccng2</i> (cyclin G2) expression showed the greatest decrease after Cn/NFAT inhibition. …”

Modulation of HS α4β2 receptors with a low concentration of arecoline. by Roger L. Papke (685990)

“…After 8 minutes the responses to a control application of ACh was reduced approximately 50%. …”

Shifts caused by control and Grin2c siRNAs in stimulation threshold and maximum response rate. by Giovanni Hernandez (236411)

“…<p><b>A-B)</b> Histogram bars represent means +/- SEM; saline injection in the VTA does not produces a reliable change in M50 nor MAX <b>C)</b> Treatment with the control siRNA did not produce a significant change in the stimulation threshold (M50), but the treatment with the siRNA against the Grin2c subunit produces a significant increase. …”

Heterogeneous species increases over time due to continuous binding of Aβ42 to the neurites. by Chun-Chieh Chang (491709)

“…The green shaded sections represent the percentage of homogeneous Aβ40 in total Aβ40 species, and show the fraction of homogeneous Aβ40 to decrease over time. …”

A small proportion of Talin molecules transmit forces at developing muscle attachments in vivo by Sandra B. Lemke (6519788)

A beneficial allele goes to fixation faster in populations with high Cra expression noise. by Michael Schmutzer (6656663)

“…Both alleles occur in cells that have the same Cra expression noise, which is given by <i>η</i>² = 10 in (A), and <i>η</i>² = 0.01 in (B). Each plot show trajectories for 50 replicate population simulations. …”

Factors associated with postoperative signs and symptoms in teeth with periapical lesion: a longitudinal study by Erlange Andrade Borges Silva (14224193)

“…Female gender (beta = 1.02; p < 0.01), mandibular teeth (beta = 25.50; p < 0.01), medium root canal amplitude (beta = 0.93; p = 0.03), and edema (beta = 1.88; p < 0.01) were associated with increased postoperative pain and tenderness, while the use of analgesics (beta = -1.82; p < 0.01) and time in days (beta = -0.23; p < 0.01) were associated with a decrease in these signs and symptoms. …”

Crystal structure and cytotoxic activities of a bis(pyrrolyl-imine) gold(III) complex by Daniel De Moraes Profirio (2885411)

“…Cytotoxic activity of [Au(pyren)]⁺ was active against three tumorigenic cell lines with IC₅₀ values of 35 μM. Interaction studies with CT-DNA by fluorescence and competition with ethidium bromide (EB) showed a quenching of the emission band of DNA with a Stern–Volmer quenching constant value of (3.0 ± 0.1) × 10⁴ M⁻¹ and a decrease in fluorescence quenching of EB-DNA system, respectively, confirming that DNA is a possible target for the complex via an intercalative binding, which was confirmed by DNA conformational changes observed with circular dichroism spectroscopy.…”

Supplementary Material for: Epidemiology of Transthyretin Familial Amyloid Polyneuropathy in Portugal: A Nationwide Study by Inês M. (5678270)

“…<b><i>Results:</i></b> Over 2010–2016 period, mean incidence rates was 0.87/100,000 (95% CI 0.68–1.10) corresponding to 71 new patients yearly, that has decreased 31% in the last 7 years. …”

Developing a continuous adjustment factor for dry matter intake of gestating and lactating ewes by Sarita Bonagurio Gallo (6677612)

Winter Conditions and Land Cover Structure the Subnivium, A Seasonal Refuge beneath the Snow by Sonia K. Petty (746990)

<i>S. aureus</i> RnpA catalyzes rRNA and mRNA digestion. by Patrick D. Olson (230450)

“…The band at ∼17.2 kDa (solid arrow; Band 2) was confirmed to be <i>S. aureus</i> RnpA by tandem mass spectrometry (Wistar Institute; Philadelphia, PA), whereas top-hits for minor contaminants (dashed arrows) were determined to be <i>E. coli</i> 50S ribosomal protein L3 (Band 1) or <i>S. aureus</i> RnpA polypeptide fragments, corresponding to amino acids 11–107 (Bands 3 and 4) or 12–107 (Band 5). …”

A small proportion of Talin molecules at muscle attachment sites in vivo are mechanically engaged. by Sandra B. Lemke (6519788)

“…(D) Talin forces measured by FLIM-FRET using the HP-sensor module (6–8 pN). A decrease in FRET efficiency of Talin-TS compared to the C-terminal zero-force control (C-TS) indicates force. …”

Data_Sheet_1_The Effect of 42-Day Exposure to a Low Deoxynivalenol Dose on the Immunohistochemical Expression of Intestinal ERs and the Activation of CYP1A1 and GSTP1 Genes in the... by Magdalena Gajęcka (11151711)

Potency of CCh (pD₂) and Atropine (pA₂) on the ileum (a, b, c) and on the colon (d, e, f) from mice with chronic colitis. by Rita Aldini (92787)

“…After induction of chronic colitis, Charbacol pEC₅₀ decreased by 8.71 times in the ileum and 2.34 times in the colon and Atropine p<i>A</i>₂ was increased by 1.35 and 3.09 times in the ileum and the colon respectively, compared with the corresponding intestinal segments of control mice. …”

Measurements of body mass index (BMI) and adipose deposits. by Jessica C. M. Hui (20370522)