DataSheet_1_Failure to decrease HbA1c levels following TB treatment is associated with elevated Th1/Th17 CD4+ responses.pdf by Robert Krause (504842)

“…</p>Results<p>CD62 P-selectin was up- (1.5-fold) and IL-10 downregulated (0.85-fold) in plasma among individuals whose HbA1c remained stable/increased during TB treatment. …”

LPC-DHA inhibits Srebp activity and de novo lipogenesis and Mfsd2a is regulated by Srebp. by Jia Pei Chan (5593388)

“…<p>(A) Western blot analysis of Scd1 and Mfsd2a expression in NSC^WT and NSC^KO treated with or without 50μM LPC-DHA. …”

Membrane-localized AR facilitates productive endocytosis and nuclear trafficking of KSHV. by Xing Wang (154377)

“…Cells were performed as mentioned above, except lacking of Triton X-100 treatment in non-permeabilized group. Scale bars represent 50 μm. (c) Knockdown of AR and EphA2 expression reduces KSHV endocytosis, as indicated by decreasing gB staining in cells. …”

Model parameters. by Nan Zhang (46264)

“…If the mask-wearing rate increases from 0% to 50%, the infection risk of norovirus would be decreased by 48.0% (95% CI, 43.5–52.3%). …”

Contribution of S4 segments and S4-S5 linkers to the low-voltage activation properties of T-type Ca_V3.3 channels by Ana Laura Sanchez-Sandoval (4885423)

“…This HVA behavior induced by IIS4C chimera was accompanied by a 2-fold decrease in the voltage-dependence of channel gating. …”

Role of the ACB domain and linker region in NMT2 activity. by Eric Soupene (64584)

“…Human NMT2 enzyme was added at a concentration of 50nM in the presence of 5μM C₁₄-CoA. …”

Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo by Zhiqiang Li (102723)

“…The overexpression of NIK plays a critical role in liver inflammatory diseases. …”

P<i>_TET</i>-driven OE of 20 genes results in decreased or increased growth rate. A. Impact of OE on the growth rates of 257 OE strains. by Murielle Chauvel (132263)

“…<p>Genes whose OE decreases or increases growth rate (≥2 fold and >2 fold, respectively) upon growth in liquid medium are listed in red or green boxes respectively. …”

microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration - Fig 6 by Surjyadipta Bhattacharjee (3181674)

“…After vacuum evaporation of HFIP, aliquoted peptide was re-suspended with DMSO to 5 mM and diluted to 5 μM into the cell culture media; <b>(B)</b> cells were treated with a scrambled miRNA-34a sequence (miRNA-34a-<b>sc</b>; 30 nM;, control, <b>a-d</b>, middle row); or <b>(C)</b> with an LNA-stabilized miRNA-34a (30 nM; miRNA-34a stressed; <b>a-d</b>; bottom row); treatments were for 24 hr before incubation with 5 uM of Aβ42 (made up as in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref033" target="_blank">33</a>]) for another 24 hr before assay; MG cells were subsequently stained using a murine amyloid beta MABN10 (red fluorescence λ_max~650 nm; anti-Aβ antibody, clone W0-2; Millipore, Bellerica MA), a TREM-2 antibody (M-227): sc-48765 (green fluorescence; λ_max~510 nm; Santa Cruz, Santa Cruz CA) or DAPI nuclear stain (blue fluorescence; λ_max~470 nm) as in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.g003" target="_blank">Fig 3</a>;</b> arrows indicate Aβ42 uptake into MG cells; note decreased presence of TREM2 in miRNA-34a treated MG cells (bottom row, panel B) and decrease in ingested Aβ42 peptide within C8B4 cells (<b>C</b>; bottom row, panel <b>d</b>). …”

Disruption of the viral cyclin has no effect on the frequency of viral genome positive cells yet results in a reduced frequency of LANA::βla+ cells. by Brian F. Niemeyer (11707995)

Twenty-two identified and replicated loci and their overlap with associations to metabolic traits and clinical phenotypes. by Johannes Raffler (793347)

“…We added their proxy variants in LD (r² ≥ 0.8; based on 1000 genomes project data [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005487#pgen.1005487.ref050" target="_blank">50</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005487#pgen.1005487.ref051" target="_blank">51</a>]). …”

Video_1_Stability of Zircon and Its Isotopic Ratios in High-Temperature Fluids: Long-Term (4 months) Isotope Exchange Experiment at 850°C and 50 MPa.mov by Ilya N. Bindeman (2843150)

“…Here, we report results of a nano- to micrometer-scale investigation of isotopic exchange using natural zircon from Mesa Falls Tuff (Yellowstone) treated with quartz-saturated, isotopically (¹⁸O, D, ⁷Li, and ¹¹B) labeled water with a nominal δ¹⁸O value of +450%0 over 4 months at 850°C and 50 MPa. …”

Presentation_1_Stability of Zircon and Its Isotopic Ratios in High-Temperature Fluids: Long-Term (4 months) Isotope Exchange Experiment at 850°C and 50 MPa.pdf by Ilya N. Bindeman (2843150)

“…Here, we report results of a nano- to micrometer-scale investigation of isotopic exchange using natural zircon from Mesa Falls Tuff (Yellowstone) treated with quartz-saturated, isotopically (¹⁸O, D, ⁷Li, and ¹¹B) labeled water with a nominal δ¹⁸O value of +450%0 over 4 months at 850°C and 50 MPa. …”

Table_1_Stability of Zircon and Its Isotopic Ratios in High-Temperature Fluids: Long-Term (4 months) Isotope Exchange Experiment at 850°C and 50 MPa.XLS by Ilya N. Bindeman (2843150)

“…Here, we report results of a nano- to micrometer-scale investigation of isotopic exchange using natural zircon from Mesa Falls Tuff (Yellowstone) treated with quartz-saturated, isotopically (¹⁸O, D, ⁷Li, and ¹¹B) labeled water with a nominal δ¹⁸O value of +450%0 over 4 months at 850°C and 50 MPa. …”

Preliminary dose-response experiments. by Noelia Torremadé (3687523)

The frequency (<i>FD</i>) and the level (<i>LD_av</i>) of the <i>CHL1</i> mRNA decrease in lung cancer (ADC and SCC types). by Vera N. Senchenko (53211)

Supplemental Table 2 Phosphokinase Array from Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocar... by Brittany L. Allen-Petersen (14935217)

Defects in the conduction of somatosensory evoked potentials of median and tibial nerves in a healthy child and in H-ABC patient. by Jose R. Eguibar (8563227)

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”

Natural Derivatives of Selective HDAC8 Inhibitors with Potent <i>in Vivo</i> Antitumor Efficacy against Breast Cancer by Xiaoming Chen (230202)

“…Upon additional modifications of corallorazine D, a candidate compound <b>5k</b>, demonstrated remarkable inhibitory potency against HDAC8 (IC₅₀ = 0.12 ± 0.01 nM), 89-fold superior to PCI-34051. …”