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7041
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7042
Comparison of the amount of locomotor activity (mean counts per day) and the night-day ratio in control and diabetic animals submitted to two light schedules.
Published 2014“…(B) In the second light schedule, animals were submitted to successive decreases in light intensity. These SZT-diabetic mice exhibited a reduction in their total locomotor activity at the three light intensities (at 1000 lux: controls: 2099.5±122.1 counts; STZ-diabetic: 1704.7±125.9 counts; p≤0.01; at 300 lux: controls: 2658.7±112.9 counts; STZ-diabetic: 2124.4±0.1 counts; p≤0.001 and at 100 lux: controls: 2864.7±58.4 counts; STZ-diabetic: 2508.7±47.5 counts; p≤0.05), with a significant decreased ratio of night-day activity at 300 lux and 100 lux. …”
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7043
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7044
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7045
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7046
Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma
Published 2017“…Rational design, guided by X-ray analysis of several inhibitors bound to human chitotriosidase (hCHIT1), led to the identification of compound <b>7f</b> as a highly potent AMCase inhibitor (IC<sub>50</sub> values of 14 and 19 nM against human and mouse enzyme, respectively) and selective (>150× against mCHIT1) with very good PK properties. …”
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7047
Cell death and JNK activation in SH-SY5Y cells stimulated with H<sub>2</sub>O<sub>2</sub> overnight or for 3 h.
Published 2013“…<b>D</b>) Cell viability assay was performed employing MTT colorimetric method. A concentration dependent decrease in cell viability is observed following 3 h stimulation with H<sub>2</sub>O<sub>2</sub> (50 mM: ∼30%; 75 mM: ∼50%). …”
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7048
Kinetic analysis of inorganic phosphate transport in oocytes expressing NPT2a or co-expressing NPT2a and CFTR.
Published 2012“…Data were fitted to the modified Hill equation. Results, as means ± SD, were as follows: the apparent K<sub>m</sub> for Na<sup>+</sup> substrate was 40.7 ± 14.6 in NPT2a-oocytes, not different from 41.8 ± 13.4 mM in NPT2a+CFTR-oocytes; IPi<sub>max</sub> was decreased by 39±7% in NPT2a+CFTR-oocytes compared to NPT2a-oocytes (P < 0.05). …”
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7049
S1 Data -
Published 2024“…Additionally, 12 hours post-treatment, catalase (an antioxidant enzyme) activity decreased 1.5-fold in a dose-dependent manner, while glutathione S-transferase (a detoxification enzyme) activity increased 7.8-fold. …”
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7050
Ablation of <i>PC3/Tis21</i> impairs terminal differentiation of 1- to 5-day-old adult-generated dentate gyrus progenitor cells.
Published 2009“…<p>New stem and progenitor cells (<b>A–D</b>) and post-mitotic neurons (<b>E–I</b>) of 1 to 5 days of age, as detected by incorporation of BrdU after five daily injections in P60 <i>PC3/Tis21</i><sup>+/+</sup> and <i>PC3/Tis21</i><sup>−/−</sup> mice (referred to as Tis21 throughout the figures), were analyzed by the expression of specific markers through multiple-labeling confocal microscopy. …”
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7051
S2 File -
Published 2023“…This initial increase and subsequent decrease in K6 and FCV-19S were more prominent in individuals with high trait anxiety (K6: B = 1.55, 95% CI = 1.18 to 1.91; FCV-19S: B = 4.27, 95% CI = 2.50 to 6.04) and in occupations other than physicians or nurses. …”
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7052
S1 File -
Published 2023“…This initial increase and subsequent decrease in K6 and FCV-19S were more prominent in individuals with high trait anxiety (K6: B = 1.55, 95% CI = 1.18 to 1.91; FCV-19S: B = 4.27, 95% CI = 2.50 to 6.04) and in occupations other than physicians or nurses. …”
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7053
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7054
Supplementary Material for: Association of Four Genetic Loci with Uric Acid Levels and Reduced Renal Function: The J-SHIPP Suita Study
Published 2010“…<i>Results:</i> Serum UA levels were significantly different between the SLC22A12 rs11231825 (CC/CT/TT: 4.5 ± 1.6, 5.0 ± 1.4, 5.3 ± 1.4 mg/dl; p = 7.6 × 10<sup>–20</sup>), SLC2A9 rs1014290 (TT/TG/GG: 4.9 ± 1.4, 5.1 ± 1.4, 5.3 ± 1.4 mg/dl; p = 3.1 × 10<sup>–11</sup>) and ABCG2 rs2231142 (TT/TG/GG: 5.3 ± 1.5, 5.2 ± 1.4, 5.1 ± 1.4 mg/dl; p = 2.0 × 10<sup>–5</sup>) genotypes. …”
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7055
REG-O3 chimeric peptide combining growth hormone and somatostatin sequences improves joint function and prevents cartilage degradation in rat model of traumatic knee osteoarthritis
Published 2020“…The effect of REG-O3, solubilized in a liposomal solution and injected at either 5, 25 or 50 μg/50 μL, was compared to liposomal (LIP), dexamethasone and hyaluronic acid (HA) solutions. …”
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7056
Evaluation of the temperature of posterior lower limbs skin during the whole body vibration measured by infrared thermography: Cross-sectional study analysis using linear mixed eff...
Published 2019“…</p><p>Conclusions</p><p>The acute exposure of 60-second mechanical vibration has effect on the behavior of Tsk of the posterior region of the lower limbs, which is likely to be associated with a decrease on the blood flow due to WBVE. It is speculated that during WBVE a greater supply of blood is required where the body responds by shunting blood flow from the skin to working muscle in the first seconds of exercise. …”
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7057
Chemoenzymatic Approach for the Proteomics Analysis of Mucin-Type Core‑1 O‑Glycosylation in Human Serum
Published 2018“…Human serum is a complex body fluid that contains various N-linked and O-linked glycoproteins. …”
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7058
Chemoenzymatic Approach for the Proteomics Analysis of Mucin-Type Core‑1 O‑Glycosylation in Human Serum
Published 2018“…Human serum is a complex body fluid that contains various N-linked and O-linked glycoproteins. …”
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7059
Chemoenzymatic Approach for the Proteomics Analysis of Mucin-Type Core‑1 O‑Glycosylation in Human Serum
Published 2018“…Human serum is a complex body fluid that contains various N-linked and O-linked glycoproteins. …”
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7060
Chemoenzymatic Approach for the Proteomics Analysis of Mucin-Type Core‑1 O‑Glycosylation in Human Serum
Published 2018“…Human serum is a complex body fluid that contains various N-linked and O-linked glycoproteins. …”