Differential expression of innate immune genes in response to PAMPs in controls and BRD diagnosed calves is in response to TLR1/2 ligand Pam3CSK4. by Cian Reid (17274007)

320-row CT transcatheter aortic valve replacement planning with a single reduced contrast media bolus injection by Daddy Mata-Mbemba (5746847)

“…</p><p>Methods</p><p>50 consecutive patients (82.6±6.9 years; 56% female) were prospectively enrolled and underwent a TAVR planning using a 320-row CT, with ECG-gated aortic root CTA immediately followed by a non-gated aorto-iliac acquisition, all within a single bolus of 40-70mL of Iohexol 350mgI/mL. …”

Research data for paper ‘Interneuronal mechanisms for learning-induced switch in a sensory response that anticipates changes in behavioural outcomes’. by Zsolt Pirger (10054930)

Image_1_Molecular mechanisms regulating natural menopause in the female ovary: a study based on transcriptomic data.jpeg by Quan Liu (486219)

“…Increased contents of terminally differentiated HMGB1+ Granulosa and GSTA1+ Granulosa were observed in the ovaries of individuals aged 50-69. Signaling pathway activity analysis indicated a gradual decrease in TGFb and MAPK pathway activity with menopause progression, while p53 pathway activity increased. …”

Image_2_Molecular mechanisms regulating natural menopause in the female ovary: a study based on transcriptomic data.jpeg by Quan Liu (486219)

“…Increased contents of terminally differentiated HMGB1+ Granulosa and GSTA1+ Granulosa were observed in the ovaries of individuals aged 50-69. Signaling pathway activity analysis indicated a gradual decrease in TGFb and MAPK pathway activity with menopause progression, while p53 pathway activity increased. …”

Image_2_Molecular mechanisms regulating natural menopause in the female ovary: a study based on transcriptomic data.jpeg by Quan Liu (486219)

“…Increased contents of terminally differentiated HMGB1+ Granulosa and GSTA1+ Granulosa were observed in the ovaries of individuals aged 50-69. Signaling pathway activity analysis indicated a gradual decrease in TGFb and MAPK pathway activity with menopause progression, while p53 pathway activity increased. …”

Detection of Proteome Changes in Human Colon Cancer Induced by Cell Surface Binding of Growth-Inhibitory Human Galectin‑4 Using Quantitative SILAC-Based Proteomics by Malwina Michalak (505581)

“…The strongest induction was found for CALB2 (calretinin; ∼24-fold), TGM2 (protein-glutamine γ-glutamyltransferase 2; ∼11-fold), S100A3 (∼10-fold), and GSN (gelsolin; 9.5-fold), and the most pronounced decreases were seen for CDKN2A (tumor suppressor ARF; ∼6-fold), EPCAM (epithelial cell adhesion molecule; ∼6-fold), UBE2C (ubiquitin-conjugating enzyme E2 C; ∼5-fold), KIF2C (kinesin-like protein KIF2C; 5-fold), and LMNB1 (lamin-B1; ∼5-fold). …”

Detection of Proteome Changes in Human Colon Cancer Induced by Cell Surface Binding of Growth-Inhibitory Human Galectin‑4 Using Quantitative SILAC-Based Proteomics by Malwina Michalak (505581)

“…The strongest induction was found for CALB2 (calretinin; ∼24-fold), TGM2 (protein-glutamine γ-glutamyltransferase 2; ∼11-fold), S100A3 (∼10-fold), and GSN (gelsolin; 9.5-fold), and the most pronounced decreases were seen for CDKN2A (tumor suppressor ARF; ∼6-fold), EPCAM (epithelial cell adhesion molecule; ∼6-fold), UBE2C (ubiquitin-conjugating enzyme E2 C; ∼5-fold), KIF2C (kinesin-like protein KIF2C; 5-fold), and LMNB1 (lamin-B1; ∼5-fold). …”

Overexpression of Rab26 restricts insulin secretion in β-cells. by Ruijuan Zhuang (3938915)

The p21 ELISA assay was used to assess the effects of MBC-005 on tumor cell expression of p21. by Bryan S. Margulies (21492667)

Table 1_A dosimetric comparison of non-coplanar volumetric modulated arc therapy and non-coplanar fixed field intensity modulated radiation therapy in hippocampus-avoidance whole-b... by Huaqu Zeng (20601563)

“…</p>Method<p>A total of 22 patients with brain metastases were retrospectively enrolled. …”

Divergent signalling pathways mediate the effects of Aβ on Homer1b and Shank1 cluster dispersal. by Francesco Roselli (211670)

“…Wort+Aβ and Wort alone; p<0.05). Notably, wortmannin itself decreased Shank1 (but not Homer1b) cluster size (74.3±10.3%, cf. …”

Table1_The real-world analysis of adverse events with teduglutide: a pharmacovigilance study based on the FAERS database.pdf by Xiaogan Wang (4978514)

Image_1_Cellular and Humoral Immune Responses and Breakthrough Infections After Two Doses of BNT162b Vaccine in Healthcare Workers (HW) 180 Days After the Second Vaccine Dose.TIFF by Alessandra Mangia (626370)

“…The vaccine-specific humoral response was quantitatively determined by testing for IgG anti-S1 domain of SARS-CoV-spike protein. Live virus microneutralization (MN) was evaluated by an assay performing incubation of serial 2-fold dilution of human serum samples, starting from 1:10 to 1:5120, with an equal volume of Wuhan strain and Delta VOC viral solution and assessing the presence/absence of a cytopathic effect. …”

Image_2_Cellular and Humoral Immune Responses and Breakthrough Infections After Two Doses of BNT162b Vaccine in Healthcare Workers (HW) 180 Days After the Second Vaccine Dose.TIFF by Alessandra Mangia (626370)

“…The vaccine-specific humoral response was quantitatively determined by testing for IgG anti-S1 domain of SARS-CoV-spike protein. Live virus microneutralization (MN) was evaluated by an assay performing incubation of serial 2-fold dilution of human serum samples, starting from 1:10 to 1:5120, with an equal volume of Wuhan strain and Delta VOC viral solution and assessing the presence/absence of a cytopathic effect. …”

Tone evoked ABR thresholds were measured in a subset of exposed mice at baseline, and at 1, 4, and 8 weeks post-exposure. by Laetitia Mwilambwe-Tshilobo (793415)

“…Thresholds were defined as the frequency shift that caused 50% inhibition of the maximum ASR. (C) Tone exposure in Tinnitus(+) mice led to a decrease in frequency discrimination for the 12 kHz tone at 8 weeks post-exposure, and at 4 weeks post-exposure for the 22 kHz tone. …”

Differences in Oxygen-Induced Retinopathy Susceptibility Between Two Sprague Dawley Rat Vendors: A Comparison of Retinal Transcriptomes by Haeyeon Lee (10308592)

“…Oxygen-induced retinopathy was induced with the rat 50/10 model.</p> <p>Pups from Charles River Laboratories developed a more severe oxygen-induced retinopathy phenotype, with 3.6-fold larger percent avascular area at P15 and twofold larger % neovascular area at P20 than pups from Envigo. …”

Engineering the Cyclization Loop of MCoTI-II Generates Targeted Cyclotides that Potently Inhibit Factor XIIa by Sixin Tian (7026710)

“…Here, we engineered the native biosynthetic cyclization loop of MCoTI-II (loop 6) to generate improved FXIIa inhibitors. Decreasing the loop length led to gains in potency up to 7.7-fold, with the most potent variant having five residues in loop 6 (<i>K</i>_i = 25 nM). …”

Assessing the benefits of five years of different approaches to treatment of urogenital schistosomiasis: A SCORE project in Northern Mozambique by Anna E. Phillips (4050331)

“…<i>haematobium</i> was seen in adults even in the SBT arms implying the rate of transmission in the community had been decreased, even where only school children have been treated, which has significant logistical and cost-saving implications for a national control programme in justifying CWT.…”

LBH589 induced DNA fragmentation and cell cycle disorder in SK-NEP-1 and G401 cells. by Tao Yan-Fang (770096)

“…<p>(A) Micrographs following Hoechst 33342 staining of cells treated with LBH589 (50 nM and 100nM) for 24 h. …”