DataSheet_1_A Pathogenic Missense Variant in NFKB1 Causes Common Variable Immunodeficiency Due to Detrimental Protein Damage.pdf by Manfred Fliegauf (391677)

“…The missense change disabled processing of the precursor to prevent the generation of mutant p50. Unlike the wildtype p50, the overexpressed mutant p50-Tyr350Cys was also not sustainable and showed a conspicuous subnuclear mislocalization with accumulation in dense aggregates instead of a homogenous distribution. …”

DataSheet_1_A Pathogenic Missense Variant in NFKB1 Causes Common Variable Immunodeficiency Due to Detrimental Protein Damage.pdf by Manfred Fliegauf (391677)

“…The missense change disabled processing of the precursor to prevent the generation of mutant p50. Unlike the wildtype p50, the overexpressed mutant p50-Tyr350Cys was also not sustainable and showed a conspicuous subnuclear mislocalization with accumulation in dense aggregates instead of a homogenous distribution. …”

Supplementary Material for: Low-Dose Alcohol-Induced Inhibition of Mouse Orthotopically Transplanted Tumors Is Associated with T-Cell Response by Kimoto A. (12549820)

Table 1_The association between myopia and mental health among Chinese children in primary and secondary school: a cross-sectional study.docx by Shijie Yu (511369)

“…</p>Results<p>Among all children, 836 children (50.98%) were boys; the mean age was 9.39 ± 2.22 years old. …”

Data Sheet 1_Effect of music therapy on children with autism spectrum disorders in the Chinese population: a systematic review and meta-analysis.docx by Yajing Yang (2105431)

“…The results showed that MT significantly decreased the total ATEC (autism treatment evaluation checklist) score (SMD = -2.52, 95% CI: -3.69 ~ -1.35, P < 0.001), ABC (autism behavior checklist) (SMD = -1.07, 95% CI: -1.52 ~ -0.61, P < 0.001), and CARS (childhood autism rating scale) score (SMD = -1.50, 95% CI: -2.26 ~ -0.74, P < 0.001). …”

Table_2_Association of Circulating Magnesium Levels in Patients With Alzheimer's Disease From 1991 to 2021: A Systematic Review and Meta-Analysis.DOC by Ke Du (511486)

“…There was statistically non-significant for Mg level in CSF between AD and HCs, whereas a decreased tendency were detected (SMD = −0.16; 95% CI [−0.50, 0.18]; P = 0.364). .In addition, when we analyzed the Mg levels of serum, plasma and CSF together, the circulating Mg levels in AD patients was significantly lower (SMD = −0.74, 95% CI [−1.13; −0.35]; P = 0.000). …”

Supplementary Material for: The 21-Year Trend of Stroke Incidence in a General Japanese Population: Results from the Takashima Stroke Registry, 1990–2010 by Takashima N. (5218427)

“…The purpose of this study is to determine these trends in stroke incidence using a population-based registry. <b><i>Methods:</i></b> Data were obtained from the Takashima Stroke Registry, which covers approximately 50,000 residents in Takashima City, Japan. …”

Data Sheet 1_The efficacy and safety of danuglipron and orforglipron in patients with type 2 diabetes and obesity: a systematic review and meta-analysis.docx by Jingjing Zhou (179820)

“…Meta-analysis results demonstrated that danuglipron significantly decreased HbA1c (mean difference [MD]: −0.90; 95% CI: −1.06, −0.74), FPG (MD: −24.66; 95% CI: −30.45, −18.86) and weight (MD: −2.17; 95% CI: −3.10, −1.23) and improved FPI (MD: 2.94; 95% CI: 1.50, 4.38). …”

Table_1_Association of Circulating Magnesium Levels in Patients With Alzheimer's Disease From 1991 to 2021: A Systematic Review and Meta-Analysis.DOCX by Ke Du (511486)

“…There was statistically non-significant for Mg level in CSF between AD and HCs, whereas a decreased tendency were detected (SMD = −0.16; 95% CI [−0.50, 0.18]; P = 0.364). .In addition, when we analyzed the Mg levels of serum, plasma and CSF together, the circulating Mg levels in AD patients was significantly lower (SMD = −0.74, 95% CI [−1.13; −0.35]; P = 0.000). …”

Video_1_The interpositional bypass with a parietal branch of superficial temporal artery graft for symptomatic atherosclerotic anterior cerebral artery stenosis or occlusion.MP4 by Chuyang Tai (18312727)

“…The ratio of ipsilateral/contralateral mean transit time in the superior frontal gyrus was decreased significantly after bypass (1.08 ± 0.07 vs. 1.23 ± 0.05, p < 0.001) and continued to decrease 6 months after surgery (1.05 ± 0.04 vs. 1.08 ± 0.07, p = 0.002). …”

A 3D tissue-wide analysis allows cell-level investigation of tissue shape maintenance during vertebrate retinal PSE growth. by Marija Matejčić (5620535)

“…<p>(A) Schematic of vertebrate retinal development. …”

Control (Ctrl) GECs are more susceptible to injury compared to iPLA₂γ KO GECs. by Andrey V. Cybulsky (4007012)

Table 1_Changes in self-reported alcohol consumption at high and low consumption in the wake of the COVID-19 pandemic: a test of the polarization hypothesis.docx by Alexander Tran (11038679)

“…It was hypothesized that the COVID-19 pandemic led to a polarization of drinking–that is, heavy drinkers increased their drinking, while light to moderate drinkers decreased their drinking. …”

Changes in Microbial Communities, Including both Uncultured and Culturable Bacteria, with Mid-Ocean Ballast-Water Exchange during a Voyage from Japan to Australia by Akiko Tomaru (511024)

Repeat administration of M002 and irradiation to neuroblastoma xenografts. by Lauren A. Gillory (469462)

“…The second group received a repeat low dose of XRT (3 Gy) directed to the tumor (M002 + XRT × 2), and the third group received a second dose of intratumoral M002 (1 × 10⁴ PFU / 50μL) with a low dose XRT (3 Gy) [(M002 + XRT) × 2]. …”

Impact of water column attenuation on achromatic contrast (Δ<i>S</i>_<i>AC</i>) to fish (A) and bird (B) models. by Brandon J. Russell (793587)

“…Dashed line represents a ratio of 1 (no change). Decrease in achromatic contrast was generally low, except for the avian predator under the 5 m conditions, where median Δ<i>S</i>_<i>AC</i> of both species decreased by 15% and up to 50% for some individuals. …”

DataSheet_1_Association between dietary antioxidant levels and chronic obstructive pulmonary disease: a mediation analysis of inflammatory factors.docx by Ziyi Liu (1540222)

“…</p>Results<p>This study included 8257 participants (4111 women [weighted, 50.7%]; mean [SD] age, 58.8 [11.2] years). In a multivariable-adjusted model of single antioxidant intake, a linear downward association between carotenoid intake and the incidence of COPD (P for trend = 0.052; Pnon- linear = 0.961). …”

Table_1_Characteristics of second primary breast cancer after ovarian cancer: a Korea central cancer registry retrospective study.docx by Eun-Gyeong Lee (627417)

“…</p>Results<p>Among the 228,329 patients included, 228,148 were patients with PBC, and 181 patients had SPBC diagnosed after ovarian cancer (OC). The mean ages at diagnosis were 56.09 ± 10.81 years for SPBC and 50.65 ± 11.40 years for PBC. …”

Deep neural network reliably determines the emitter's sex from individual vocalizations. by A. Ivanenko (9010331)

“…Correspondingly the change in the network's weights (light red) progressively decreased after stabilizing after ~6k iterations. Data shown for a representative training run. …”

Table_1_The Rapid Population Collapse of a Key Marine Predator in the Northern Antarctic Peninsula Endangers Genetic Diversity and Resilience to Climate Change.docx by Douglas J. Krause (4630831)

“…To update the population status of SSI AFS, we analyzed 20 years of field-based data including population counts, body size and condition, natality, recruitment, foraging behaviors, return rates, and pup mortality at the largest SSI colony. Our findings show a precipitous decline in AFS abundance (86% decrease since 2007), likely driven by leopard seal predation (increasing since 2001, p << 0.001) and potentially worsening summer foraging conditions. …”