Making Acute Tests More Ecologically Relevant: Cadmium Bioaccumulation and Toxicity in an Estuarine Clam under Various Salinities Modeled in a Toxicokinetic–Toxicodynamic Framework... by Qiao-Guo Tan (1422556)

“…The model developed in this study could provide predictions of no-effect concentration (1.7 to 34.9 μg L^–1, end point mortality) and the median lethal concentration (LC₅₀) of Cd at different salinities. In conclusion, we developed a framework for quantifying the multiple effects of salinity and a method for estimating no-effect concentration from acute toxicity tests, which can be used for better assessments of metal risks in estuarine waters.…”

Benzalkonium Chloride Disinfectants Induce Apoptosis, Inhibit Proliferation, and Activate the Integrated Stress Response in a 3‑D <i>in Vitro</i> Model of Neurodevelopment by Josi M. Herron (8068040)

“…By using immunostaining and cell cycle analysis, we found that both BACs induced apoptosis and decreased proliferation of NPCs. To explore the mechanisms underlying their effect on neurosphere growth, we carried out RNA sequencing on neurospheres exposed to each BAC at 50 nM for 24 h, which revealed the activation of the integrated stress response by both BACs. …”

Table_1_Immediate modulatory effects of transcutaneous vagus nerve stimulation on patients with Parkinson’s disease: a crossover self-controlled fMRI study.docx by Chengwei Fu (12129339)

“…Real taVNS was associated with a widespread decrease in ALFF in the right hemisphere, including the superior parietal lobule, precentral gyrus, postcentral gyrus, middle occipital gyrus, and cuneus (voxel p < 0.001, GRF corrected). …”

Supplementary Material for: Practical Value of Anti-Xa Activity in the Evaluation of Extracorporeal Circuit Anticoagulation during Haemodialysis: Results of a Cross-Sectional Singl... by Coene K.L.M. (4545349)

“…<b><i>Conclusion:</i></b> Anti-Xa activity measurements during dialysis can identify patients in whom LMWH dosage should be lowered in a subsequent dialysis session. Whether such an intervention leads to a decrease in haemorrhagic complications needs to be evaluated in prospective studies.…”

Table_1_Multidimensional Mutational Profiling of the Indian HNSCC Sub-Population Provides IRAK1, a Novel Driver Gene and Potential Druggable Target.xlsx by Sagar Sanjiv Desai (11634628)

“…Modelling of the IRAK1 mutation showed a decrease in its binding to known IRAK1 inhibitors.…”

Table_1_Immediate modulatory effects of transcutaneous vagus nerve stimulation on patients with Parkinson’s disease: a crossover self-controlled fMRI study.docx by Chengwei Fu (12129339)

“…Real taVNS was associated with a widespread decrease in ALFF in the right hemisphere, including the superior parietal lobule, precentral gyrus, postcentral gyrus, middle occipital gyrus, and cuneus (voxel p < 0.001, GRF corrected). …”

Table_1_Immediate modulatory effects of transcutaneous vagus nerve stimulation on patients with Parkinson’s disease: a crossover self-controlled fMRI study.docx by Chengwei Fu (12129339)

“…Real taVNS was associated with a widespread decrease in ALFF in the right hemisphere, including the superior parietal lobule, precentral gyrus, postcentral gyrus, middle occipital gyrus, and cuneus (voxel p < 0.001, GRF corrected). …”

Data Sheet 1_Impact of finerenone on chronic kidney disease progression in Chinese patients with type 2 diabetes: a FIGARO-DKD subgroup analysis.docx by Ping Li (31981)

“…Finerenone resulted in a numerical decrease in the risk of the cardiovascular composite outcome (hazard ratio 0.91; 95% confidence interval 0.50–1.67) and a significantly reduced risk of the key secondary kidney outcome (hazard ratio 0.48; 95% confidence interval 0.29–0.79; p = 0.0029). …”

Presentation_1_Multidimensional Mutational Profiling of the Indian HNSCC Sub-Population Provides IRAK1, a Novel Driver Gene and Potential Druggable Target.pptx by Sagar Sanjiv Desai (11634628)

“…Modelling of the IRAK1 mutation showed a decrease in its binding to known IRAK1 inhibitors.…”

Additional file 3 of C. elegans as a test system to study relevant compounds that contribute to the specific health-related effects of different cannabis varieties by Monique van Es-Remers (13895294)

“…In this assay C. elegans was exposed to different concentrations (5, 50 and 100 μg/mL) of the Non-Polar Fractions both in carboxylated (NPFdec) and non-decarboxylated (NPF) form. …”

Evolution of a tumour spheroid and associated variables in time, including the tumour cell, oxygen, free and bound polymersome concentrations for <i>n</i> = 5. by Hannah West (11172998)

“…Initially growth occurs with no free polymersomes on the tumour surface up to a radius of 175<i>μm</i>, then we introduce polymersomes by setting <i>V</i>_∞ = 10 when 40 ≤ <i>t</i> ≤ 50 days. …”

Incidence rates and temporal trends of cervical cancer relating to opportunistic screening in two developed metropolitan regions of Brazil: a population-based cohort study by Júlio César Teixeira (7824356)

“…There was an increasing APC trend in Campinas among women aged 15-24 years, and a decreasing IR trend for squamous-cell histology in both regions (P < 0.05). …”

Microwave ablation combined with anti-PD-1/CTLA-4 therapy induces an antitumor immune response to renal cell carcinoma in a murine model by Run-Qi Guo (13266491)

“…MWA treatment increased PD-L1/PD-1 expression; however, after the combination treatment with ICI, PD-L1/PD-1 expression was decreased. According to the rechallenge test, mice (16.7%) in the MWA group, ICI group (50%), and MWA+ICI group (66.7%) exhibited successful tumor rejection, whereas no mice in the control group exhibited the capability of tumor rejection. …”

MicroRNA regulation of cellular mRNAs during influenza virus infection. by William A. Buggele (463461)

“…<div><p>(A) A549 cells were mock infected, infected with A/WSN/33 (5 pfu/cell), or infected after transfection with an equimolar mixture of miRNAs (50nM final concentration) that included either hsa-miR-141, hsa-miR-374b, hsa-miR-449b, hsa-miR-518b, and hsa-miR-1263 (G1), or hsa-miR-147b, hsa-miR-190b, hsa-miR-199a-5p, hsa-miR-512-5p, and hsa-miR-874 (G2). …”

Access to the Peripheral Circulation Is Required for Viral Persistence in the Simulation by Karen A Duca (80676)

“…Small incremental decreases below 50% immunosuppression resulted in clearance of Vir similar to that seen in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.0030137#ppat-0030137-g005" target="_blank">Figure 5</a>A.…”

DataSheet_1_Toxicity, baseline of susceptibility, detoxifying mechanism and sublethal effects of chlorogenic acid, a potential botanical insecticide, on Bemisia tabaci.docx by Ran Wang (169166)

“…<p>Bemisia tabaci is a threat to agriculture worldwide because of its potential to cause devastating damage to crops. …”

Effect of a roadblock on ParB2-mediated stimulation of <i>oriII</i> activity in <b><i>E. coli</i></b>. by Tatiana Venkova-Canova (424756)

“…For determining generation times, the cultures were diluted 50× and grown to early log phase. The generation times are from five different cultures, and they decreased in the presence of IPTG in all cases, but less so under the condition RepA was expected to bind to P1 iterons and create roadblock (Table row #4). …”

A Small-Molecule Inhibitor of <em>T. gondii</em> Motility Induces the Posttranslational Modification of Myosin Light Chain-1 and Inhibits Myosin Motor Activity by Aoife T. Heaslip (207534)

“…<div><p><em>Toxoplasma gondii</em> is an obligate intracellular parasite that enters cells by a process of active penetration. Host cell penetration and parasite motility are driven by a myosin motor complex consisting of four known proteins: TgMyoA, an unconventional Class XIV myosin; TgMLC1, a myosin light chain; and two membrane-associated proteins, TgGAP45 and TgGAP50. …”

Table1_Ocean warming enhances the competitive advantage of Ulva prolifera over a golden tide alga, Sargassum horneri under eutrophication.docx by Hailong Wu (84632)

“…In monocultures, the growth of U. prolifera and S. horneri, along with pigment concentrations and photosynthesis, increased with rising temperature, reaching a plateau at 15 - 25°C. However, when the temperature increased to 30°C, the growth of U. prolifera and S. horneri decreased abruptly, with S. horneri even suffering death. …”

A quantitative image-based screen identified host factors that affect <i>L</i>. <i>monocytogenes</i> invasion and cell-to-cell spread. by Michelle Rengarajan (2723380)

“…<p><b>(A</b>) Illustration of hypothetical phenotypes that can be identified in the screen. …”