Ca²⁺ sparklets in DSM occur at different frequencies in the presence of CPA (10 μM). by Peter Sidaway (190696)

“…<p>Overlaid images (x60) of a preparation where (A) CPA (10 μM) caused an increase in sparklet frequency, and (D) where CPA (10 μM) caused a decrease in sparklet frequency, compared with the controls. …”

In Situ Visualization of Concentration Polarization during Membrane Ultrafiltration Using Microscopic Laser-Induced Fluorescence by Bo-yang Meng (6334016)

“…The results showed that CP reached the steady state approximately 1 min after the filtration condition change. A higher cross-flow velocity and/or a lower TMP decrease the CP concentration and thickness. …”

<i>In vitro</i> binding properties of <i>S</i>. <i>carpocapsae</i> FARs to fatty acids. by Sophia C. Parks (11624976)

“…C&D) When DAUDA is bound to FAR (13 μM) <i>in vitro</i>, a ~50nm blue shift is observed in the peak. E&F) Full curve of <i>in vitro</i> competition assays shows a decrease in fluorescence when linoleic acid (10 μM) binds to and therefore displaces DAUDA (1 μM) from the fatty-acid binding pocket of FAR. …”

The 4-aminopyridyl-based lead compounds. by Claudia Magalhaes Calvet (3601919)

“…Both compounds have EC₅₀ in low nanomolar range against cultured amastigotes, are orally bioavailable and decrease 99% parasitemia in mice after 4-day oral dosing [<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0006132#pntd.0006132.ref035" target="_blank">35</a>,<a href="http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0006132#pntd.0006132.ref037" target="_blank">37</a>].…”

Visualization of association between score and threshold intensity and/or age. by Pavel Mareš (5689268)

“…<p>The multiplot visualizes the association of score (1–5) and (A) stimulation threshold or (B) age in males (blue) or females (red). …”

Interactions between asymmetric distribution of damage and repair by Martin Ackermann (36108)

“…After generation 50 000, asymmetry was free to evolve and increased to a value of one, while the investment in repair decreases. …”

Model results of the effects of developmental interactions on transient alpha diversity and stationary beta diversity in an environment discretized into 25 patches (see S9 Fig). by Fernando W. Rossine (8599806)

“…In a stochastic environment with mean starvation time = 430 hours (symbol with black boundary in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000642#pbio.3000642.g005" target="_blank">Fig 5E</a>), the mean extinction time decreases (decreased transient alpha diversity), but the variability in the winner across patches increases compared to segregated development (increased stationary beta diversity). …”

Epigenetic Inactivation of Notch-Hes Pathway in Human B-Cell Acute Lymphoblastic Leukemia by Shao-Qing Kuang (217209)

“…Aberrant methylation of Notch3 and Hes5 in B-ALL was associated with gene silencing and was accompanied by decrease of H3K4 trimethylation and H3K9 acetylation and gain of H3K9 trimethylation and H3K27 trimethylation. 5-aza-2′-deoxycytidine treatment restored Hes5 expression and decreased promoter hypermethylation in most leukemia cell lines and primary B-ALL samples. …”

GFA does not affect HCHO metabolism in <i>E</i>. <i>coli</i> cell lysate. by Richard J. Hopkinson (838133)

“…<i>coli</i> BL21 (DE3) cell lysate (0.5 mg/mL in 50 mM Tris buffer pH 7.5) incubated with [¹³C]-HCHO (6 mM). …”

Image1_Lonicerin attenuates house dust mite-induced eosinophilic asthma through targeting Src/EGFR signaling.jpg by Zhenan Deng (14297111)

“…Finally, in vivo experiments confirmed that lonicerin inhibited activation of the Src/EGFR pathway by decreasing their phosphorylation. Taken together, the present study demonstrated that lonicerin could suppress HDM-induced eosinophilic asthma in mice through inhibiting the activation of Src/EGFR pathway, which also provides a basis for further research as a new potentially therapeutic agent for eosinophilic asthma and its underlying mechanisms in the future.…”

Table1_Lonicerin attenuates house dust mite-induced eosinophilic asthma through targeting Src/EGFR signaling.xlsx by Zhenan Deng (14297111)

“…Finally, in vivo experiments confirmed that lonicerin inhibited activation of the Src/EGFR pathway by decreasing their phosphorylation. Taken together, the present study demonstrated that lonicerin could suppress HDM-induced eosinophilic asthma in mice through inhibiting the activation of Src/EGFR pathway, which also provides a basis for further research as a new potentially therapeutic agent for eosinophilic asthma and its underlying mechanisms in the future.…”

Table2_Lonicerin attenuates house dust mite-induced eosinophilic asthma through targeting Src/EGFR signaling.xlsx by Zhenan Deng (14297111)

“…Finally, in vivo experiments confirmed that lonicerin inhibited activation of the Src/EGFR pathway by decreasing their phosphorylation. Taken together, the present study demonstrated that lonicerin could suppress HDM-induced eosinophilic asthma in mice through inhibiting the activation of Src/EGFR pathway, which also provides a basis for further research as a new potentially therapeutic agent for eosinophilic asthma and its underlying mechanisms in the future.…”

Circulating MicroRNAs as Easy-to-Measure Aging Biomarkers in Older Breast Cancer Patients: Correlation with Chronological Age but Not with Fitness/Frailty Status by Sigrid Hatse (12560)

“…Plasma levels of miR-20a-3p, miR-30b-5p, miR106b, miR191 and miR-301a were confirmed to show significant age-related decreases (all p≤0.004). …”

Table_3_Enteric nervous system damage caused by abnormal intestinal butyrate metabolism may lead to functional constipation.xlsx by Le Wang (165105)

“…<p>Functional constipation (FC) is a high morbidity gastrointestinal disease for which dysfunction in the enteric nervous system is a major pathogenesis mechanism. …”

Table3_Lonicerin attenuates house dust mite-induced eosinophilic asthma through targeting Src/EGFR signaling.xlsx by Zhenan Deng (14297111)

“…Finally, in vivo experiments confirmed that lonicerin inhibited activation of the Src/EGFR pathway by decreasing their phosphorylation. Taken together, the present study demonstrated that lonicerin could suppress HDM-induced eosinophilic asthma in mice through inhibiting the activation of Src/EGFR pathway, which also provides a basis for further research as a new potentially therapeutic agent for eosinophilic asthma and its underlying mechanisms in the future.…”

Table_2_Enteric nervous system damage caused by abnormal intestinal butyrate metabolism may lead to functional constipation.xlsx by Le Wang (165105)

“…<p>Functional constipation (FC) is a high morbidity gastrointestinal disease for which dysfunction in the enteric nervous system is a major pathogenesis mechanism. …”

Table_1_Enteric nervous system damage caused by abnormal intestinal butyrate metabolism may lead to functional constipation.xlsx by Le Wang (165105)

“…<p>Functional constipation (FC) is a high morbidity gastrointestinal disease for which dysfunction in the enteric nervous system is a major pathogenesis mechanism. …”

TNF-Tg male mice have greater tissue area compared to WT litter mates measured via histomorphometry. by Richard D. Bell (4752660)

“…Interestingly, when normalized to total area, there was a significant decrease in the White area at 3, 4, and 5.5 months in TNF-Tg mice compared to WT littermates (<b>K;</b> *p<0.0125, **p<0.01, ***p<0.001, M±SD, n = 4–6).…”

Changes in genetic diversity and the McDonald-Kreitman related index (MKR) for varying strengths of strain competition and antigenic mutation rates. by Daniel Zinder (106377)

“…<p><b>(A)</b> Mean pairwise genetic diversity π is measured as the mean distance, measured in years, for the coalescence of random pairs of contemporaneous samples in a tree. …”

Increases of oxidative stress induce reduction of ΔΨ_m in <i>DJ-1</i>+/+ MEFs. by Emilie Giaime (316501)

“…<p>(<b>A, B</b>) Confocal microscopic analysis. (<b>A</b>) Representative confocal live cell images of <i>DJ-1</i>−/− and +/+ MEFs stained with TMRM (50 nM, red) and Mitotracker Green (200 nM) after incubation with or without H₂O₂ (500 µM, 3 hr) or pyocyanin (100 µM, 24 hr). …”