Elucidation of the RamA Regulon in <i>Klebsiella pneumoniae</i> Reveals a Role in LPS Regulation by Shyamasree De Majumdar (168216)

TRPM7 is down-regulated in mouse cortical astrocytes by siRNA. by Zhao Zeng (478844)

“…<p><b>A</b>. RT-PCR shows that transfection of astrocytes with specific TRPM7 siRNA decreases the mRNA level of TRPM7 compared to those with control siRNA. …”

Change in serum HMGB1 level in the rhTM group and control group. by Hiroshige Shimizu (5279057)

“…At the 7-day follow-up examination, serum HMGB1 level was significantly lower than at onset of AE-FIP in patients treated with rhTM (8.4±6.1 vs 15.2±12.5 ng/ml, respectively; P = 0.02). In contrast, HMGB1 level did not significantly decrease in the control group (11.3±11.3 vs 8.3±5.3 ng/ml, respectively; P = 0.37).…”

Aging in mouse tail skin leads to an aberrantly weak inflammatory signature with decreased expression of <i>Lyz1</i>, <i>Lyz2</i>, <i>Clec7a</i>, <i>Cd48</i>, <i>Tyrobp</i> and <i>... by William R. Swindell (175427)

Loss of <i>FGR41</i> or <i>CWP419</i> does not impact susceptibility to cell wall stressors. by Andrew S. Wagner (11331477)

Overexpression of calcineurin effector genes does not restore calcium-induced masking in a <i>crz1Δ/Δ</i> mutant. by Andrew S. Wagner (11331477)

Botulinum toxin A-induced muscle paralysis stimulates Hdac4 and differential miRNA expression by Leah E. Worton (457030)

Multi-Cilia Cell Hyperplasia Is Due to Mib-Mediated Jagged2a Signaling Pathway via Notch1a and Notch3 Receptors by Ming Ma (43147)

“…</p><p>(C–H) Multi-cilia cell number is increased in (D and F) <i>jagged2a-atg</i> morphants compared to (C and E) wt embryos as shown by (C and D) <i>rfx2</i> and (E and F) <i>centrin2</i> expression at 24 hpf, but principal cell number is decreased in (H) <i>jagged2a-atg</i> morphants compared to (G) wt embryos as revealed by <i>Na⁺, K⁺ ATPase β1a</i> expression at 24 hpf.…”

Physio-Biochemical Composition and Untargeted Metabolomics of Cumin (<i>Cuminum cyminum</i> L.) Make It Promising Functional Food and Help in Mitigating Salinity Stress by Sonika Pandey (834285)

“…Relative water content remained unchanged up to 50 mM NaCl stress, and thereafter decreased significantly. …”

Loss of <i>FGR41</i> modestly delays hyphal development <i>in vitro</i>. by Andrew S. Wagner (11331477)

LOS sialylation does not compete with polyP for the protection from cathelicidin LL-37. by Benedetta Manca (15810991)

Linear mixed model results: Effect of bar height and approach stride number on kinetics at take-off to a jump in agility dogs. by Leena Inkilä (20614460)

LPC-DHA inhibits Srebp activity and de novo lipogenesis and Mfsd2a is regulated by Srebp. by Jia Pei Chan (5593388)

“…<p>(A) Western blot analysis of Scd1 and Mfsd2a expression in NSC^WT and NSC^KO treated with or without 50μM LPC-DHA. …”

Membrane-localized AR facilitates productive endocytosis and nuclear trafficking of KSHV. by Xing Wang (154377)

“…Cells were performed as mentioned above, except lacking of Triton X-100 treatment in non-permeabilized group. Scale bars represent 50 μm. (c) Knockdown of AR and EphA2 expression reduces KSHV endocytosis, as indicated by decreasing gB staining in cells. …”

Model parameters. by Nan Zhang (46264)

“…If the mask-wearing rate increases from 0% to 50%, the infection risk of norovirus would be decreased by 48.0% (95% CI, 43.5–52.3%). …”

Role of the ACB domain and linker region in NMT2 activity. by Eric Soupene (64584)

“…Human NMT2 enzyme was added at a concentration of 50nM in the presence of 5μM C₁₄-CoA. …”

Discovery of a Potent and Selective NF-κB-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo by Zhiqiang Li (102723)

“…The overexpression of NIK plays a critical role in liver inflammatory diseases. …”

microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration - Fig 6 by Surjyadipta Bhattacharjee (3181674)

“…After vacuum evaporation of HFIP, aliquoted peptide was re-suspended with DMSO to 5 mM and diluted to 5 μM into the cell culture media; <b>(B)</b> cells were treated with a scrambled miRNA-34a sequence (miRNA-34a-<b>sc</b>; 30 nM;, control, <b>a-d</b>, middle row); or <b>(C)</b> with an LNA-stabilized miRNA-34a (30 nM; miRNA-34a stressed; <b>a-d</b>; bottom row); treatments were for 24 hr before incubation with 5 uM of Aβ42 (made up as in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref033" target="_blank">33</a>]) for another 24 hr before assay; MG cells were subsequently stained using a murine amyloid beta MABN10 (red fluorescence λ_max~650 nm; anti-Aβ antibody, clone W0-2; Millipore, Bellerica MA), a TREM-2 antibody (M-227): sc-48765 (green fluorescence; λ_max~510 nm; Santa Cruz, Santa Cruz CA) or DAPI nuclear stain (blue fluorescence; λ_max~470 nm) as in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.g003" target="_blank">Fig 3</a>;</b> arrows indicate Aβ42 uptake into MG cells; note decreased presence of TREM2 in miRNA-34a treated MG cells (bottom row, panel B) and decrease in ingested Aβ42 peptide within C8B4 cells (<b>C</b>; bottom row, panel <b>d</b>). …”

Disruption of the viral cyclin has no effect on the frequency of viral genome positive cells yet results in a reduced frequency of LANA::βla+ cells. by Brian F. Niemeyer (11707995)

Twenty-two identified and replicated loci and their overlap with associations to metabolic traits and clinical phenotypes. by Johannes Raffler (793347)

“…We added their proxy variants in LD (r² ≥ 0.8; based on 1000 genomes project data [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005487#pgen.1005487.ref050" target="_blank">50</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005487#pgen.1005487.ref051" target="_blank">51</a>]). …”