Identification of Potent DNA Gyrase Inhibitors Active against Mycobacterium tuberculosis by Bongkochawan Pakamwong (12315428)

“…Models of complexes of compounds <b>G24</b> and <b>G26</b> bound to the M. tuberculosis DNA gyrase ATP-binding site, generated by molecular dynamics simulations followed by pharmacophore mapping analysis, showed hydrophobic interactions of inhibitor hydrophobic headgroups and electrostatic and hydrogen bond interactions of the polar tails, which are likely to be important for their inhibition. Decreasing compound lipophilicity by increasing the polarity of these tails then presents a likely route to improving the solubility and activity. …”

Fig 3 - by Masaru Sakai (1669627)

Immunoblot images of α-SMA, PCNA and Sirt1. by Hanhan Liu (568151)

Jag2 knockdown ameliorates mitochondrial dysfunction induced by hypoxia. by Hanhan Liu (568151)

Mutation prevalence of <i>podhfr</i>, <i>pocrt</i> and <i>pocytb</i> in <i>P</i>. <i>ovale curtisi</i> and <i>P</i>. <i>ovale wallikeri</i> isolates. by Jing Chen (4762)

Jag2 deficiency prevents proliferation and promotes apoptosis in hypoxia-treated PASMCs. by Hanhan Liu (568151)

Global effects of RG108 on DNA modifications and DNMTs and TETs enzymatic activities in hBMSCs. by Rahyza I. F. Assis (6037928)

“…(A) Global methylation was assessed using Imprint Methylated DNA Quantification Kit showing a significant decrease in the RG108 group. …”

The expected heterozygosity <i>(H</i>_<i>e</i>) of microsatellite loci flanking <i>podhfr</i> gene in <i>P</i>. <i>ovale curtisi</i>. by Jing Chen (4762)

Jag2 regulates mitochondrial injury in hypoxia-induced PASMCs via Sirt1 signaling. by Hanhan Liu (568151)

Quarantine effectiveness, defined as the percentage of quarantined individuals that develop an infection, as a function of the probability of infection given a contact (<i>α</i>). by Maria M. Martignoni (8563158)

RNAi-based screen for genes that modify aSyn oligomerization in living cells. by Susana A. Gonçalves (199613)

“…</b> Representative live cell imaging pictures of aSyn-BiFC stable H4 cells silenced for hits that increase (<i>RAB8B</i>, <i>RAB11A</i>, <i>RAB13</i>, <i>RAB39B</i>, <i>CAMK1</i>, <i>DYRK2</i>) or decrease (<i>CC2D1A</i>, <i>CLK4</i>, <i>SYTL5)</i> aSyn oligomerization (green). …”

Lakes in Europe harbour more anthropogenic microparticles than elsewhere. by Andrew J. Tanentzap (10227764)

Intracellular pH of <i>C</i>. <i>albicans</i> ATCC 90028; FLC-susceptible <i>C</i>. <i>albicans</i> D27and FLC-resistant <i>C</i>. <i>albicans</i> D15.9 with and without the treatm... by Mohammad Irfan (464459)

Linear mixed model results: Effect of bar height and approach stride number on sagittal joint kinematics at take-off to a jump in agility dogs. by Leena Inkilä (20614460)

The inactivation of <i>Kdm6a</i> in mice had age- and gender-dependent effects on normal hematopoiesis. by Ling Tian (107492)

Human glaucomatous trabecular cells produce SDF-1(5-67). by Alexandre Denoyer (160189)

“…MMP inhibitors batimastat (100 nM) and TIMP-1 (0.5 nM) induce a decrease in SDF-1(5-67) production, whereas TNF-α (50 ng/mL [2.9 nM]) and TGF-β2 (10 ng/mL [0.8 nM]) enhance the production of SDF-1(5-67). ** <i>P</i><0.01. …”

LV function and geometry: Exercise cohort. by Stephanie L. Samani (17896610)

“…Additionally, miR-22 and miR-30e decreased with exercise and mapped to a localized inflammatory process, the inflammasome (NLRP-3, whereby a 2-fold decrease in NLRP-3 mRNA occurred with exercise (p < 0.05).…”

S1 Graphical abstract - by Stephanie L. Samani (17896610)

“…Additionally, miR-22 and miR-30e decreased with exercise and mapped to a localized inflammatory process, the inflammasome (NLRP-3, whereby a 2-fold decrease in NLRP-3 mRNA occurred with exercise (p < 0.05).…”

Pyrazole-Infused Metal Complexes: Anticancer Activity, DNA Cleavage, and Biophysical Insights into DNA/BSA Interactions by Tankadhar Behera (22267115)

“…The cytotoxicities of dmp and its complexes were investigated using the MTT assay, with the evaluation of their IC₅₀ values for the MCF-7 and MDA-MB-231 breast cancer cell lines, as well as a normal epithelial HEK-293 cell line. …”

Islet2a morphant, but not mutant, larvae have a reduced number of dSMNs. by Rosa L. Moreno (5434796)

“…(C) Injection of the T-MO led to a decrease in the number of zn8⁺ neurons that coexpressed gfp. …”